Stefano Castellani

Evaluation of Citicoline-loaded Lutrol 127/Carbopol/Hyaluronic acid-based gels for brain delivery by intranasal administration

Anna Patrizia de Nichilo, Francesca Uberti, Adriana Trapani, Stefano Castellani et autres

The aim of this work was to evaluate two nasal gels specifically designed to meet three essential criteria: a suitable formulation for nasal administration, a pH compatible with the nasal mucosa, and the encapsulation capacity of the antioxidant Citicoline (CIT), which showed …

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Biology and function of the autotaxin/lysophosphatidic acid axis in cancer (Review)

Angelina Boccarelli, Stefano Castellani

Autotaxin (ATX) lysophospholipase D has been identified as an 'autocrine motility factor' for tumour cells. The tumour microenvironment (TME) serves a critical role in cancer development, with ATX, as a component of the ATX/lysophosphatidic acid (LPA) axis, integrated into a complex network …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Teresa Trotta, Stefano Castellani, Sante Di Gioia, Chiara Porro et autres

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Chiara Porro, Silvia Lepore, Teresa Trotta, Stefano Castellani et autres

Sputum is recognized as a very useful sampling method in Cystic Fibrosis (CF) for both research and clinical use aiding both the diagnosis and monitoring of lung disease inflammatory status. A great advantage of the technique is that it enables sampling of …

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Silvia Lepore, Teresa Trotta, Lucio Milillo, Stefano Castellani et autres

Introduction. Response of different types of cells on biomaterials is crucial for the applications of tissue engineering and regenerative medicine. It is recognized that cell behaviours depend largely by material surface characteristics. Objectives. The purpose of this study was to define the …

Comparison of numerical approaches for groundwater flow modelling within mining environment

Roberto Tonucci, Monica Ghirotti, Fabio Canova, Stefano Castellani et autres

In groundwater flow modelling within mining environments, three main numerical approaches are commonly used: i) the Equivalent Porous Media (EPM), according to which the rock mass and its discontinuities are represented as a continuum; ii) the Discrete Fracture Network (DFN), where hydraulic …

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Nanostructured lipid carriers containing Dopamine and Grape Seed Extract: evaluation of cell line-based models with application to Parkinson disease studies

Nicoletta Guaragnella, Chiara Coppola, Debora Fasano, Stefano Castellani et autres

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The host–guest inclusion complex of Anle 138b with Methyl-β-cyclodextrin: In vitro characterization and possible formulation development for anti-Parkinson application

G. Colangelo, Anna Maria Di Cosola, Rosa Angela Cardone, Nicola Margiotta et autres

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Physicochemical and Biological Properties of Quercetin-Loaded Low-Molecular-Weight Chitosan Nanoparticles Derived from Hermetia illucens Larvae and Crustacean Sources: A Comparative Study

Anna Guarnieri, Rosanna Mallamaci, Giuseppe Trapani, Dolores Ianniciello et autres

Introduction. Larvae of the insect Hermetia illucens can represent an alternative source for low-molecular-weight chitosan (CS) production compared with CS from crustaceans (CScrustac), making it appealing in terms of pharmaceutical applications. Hence, the performances of CSlarvae and CScrustac were compared herein by …

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Slightly viscous oxidized alginate dispersions as vehicles for intranasal administration of the α-synuclein aggregation inhibitor Anle 138b in free form or encapsulated in solid lipid nanoparticles

Rosanna Mallamaci, Stefano Castellani, Limosani Francesca, P. G. Medaglia et autres

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Numerical modelling for sustainable mine water management

Roberto Tonucci, Monica Ghirotti, Guido Bonfedi, Giuliana Buongiovanni et autres

Solid lipid nanoparticles for Anle 138b administration in Parkinson disease: towards an industrial scale up with nutraceutical formulations

Stefano Castellani, Rosanna Mallamaci, Nicola Zizzo, Giuseppe Passantino et autres

INTRODUCTION Anle 138b, a novel drug for geriatric application in Parkinson's disease (PD), suffers from low water solubility and, hence, low bioavailability (1-2). Therefore, the research on novel water-soluble products as a vehicle for Anle 138b still represents a challenge for the …