Lorenzo Guerra

Evaluation of Citicoline-loaded Lutrol 127/Carbopol/Hyaluronic acid-based gels for brain delivery by intranasal administration

Anna Patrizia de Nichilo, Francesca Uberti, Adriana Trapani, Stefano Castellani et autres

The aim of this work was to evaluate two nasal gels specifically designed to meet three essential criteria: a suitable formulation for nasal administration, a pH compatible with the nasal mucosa, and the encapsulation capacity of the antioxidant Citicoline (CIT), which showed …

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Structural basis of ligand selectivity in FAD/NAD(P)H‐dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli et autres

FAD/NAD(P)H-dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target …

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Suramin Interactions Across Biological Systems: From Molecular Targets to Therapeutic Implications

Alessia Catalano, Valeria Scaglione, Maria Noemi Sgobba, Lavinia Ferrone et autres

Suramin is a century-old polysulfonated naphthylurea that remains a first-line treatment for early-stage human African trypanosomiasis (HAT). Remarkably, despite its age, suramin continues to draw attention because of its unusually broad spectrum of biological activities. Historically known as an antagonist of purinergic …

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Insights into the cytotoxicity of Ganoderma adspersum mycelium extracts against human renal cancer cell lines

Nikola Schlosserová, Biagia Musio, Maria Noemi Sgobba, Federica Mastropirro et autres

Ganoderma adspersum is a medicinal fungus known for its bioactive properties, including antibacterial, anticholinesterase, and antioxidant activities. While preliminary research suggests antiproliferative effects on breast cancer cells, its efficacy against other cancer types remains underexplored. This study aims to evaluate the antiproliferative …

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The host–guest inclusion complex of Anle 138b with Methyl-β-cyclodextrin: In vitro characterization and possible formulation development for anti-Parkinson application

G. Colangelo, Anna Maria Di Cosola, Rosa Angela Cardone, Nicola Margiotta et autres

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Environmentally independent histological markers of wool quality: a comparative study of Gentile di Puglia and Sarda breeds

Rossana Topputi, Gabriela Molina, Gianluca Ventriglia, Jorge Quiroz Valiente et autres

Wool quality plays a role in determining the economic value of sheep breeds, amid the growing global demand for natural and sustainable material. This quality depends on both genetic and non-genetic factors, complicating breed evaluation. Among the most valued qualities is the …

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Structural basis of ligand selectivity in FAD/NAD(P)H-dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase

Giulia Chiara Maria Perrone, Serena Spadone, Anna Lucia Francavilla, Sara Morselli et autres

FAD/NAD(P)H-dependent dehydrogenases form a structurally conserved family of redox enzymes that participate in essential metabolic processes across parasites and higher organisms. Among them, trypanothione reductase (TR) is a key component of the redox metabolism of Leishmania species and represents an attractive target …

SLC25A mitochondrial carriers as biomarkers and therapeutic targets of spaceflight-induced dysfunction: the ADP/ATP carrier (AAC3) as a structural case study

Pietro D’Addabbo, Anna Grassi, D Luca, Valeria Scaglione et autres

BACKGROUND: Spaceflight exposes living organisms to mechanical unloading and cosmic radiation that profoundly reshape metabolism and tissue function. Because mitochondria play a crucial role in dealing with stress responses, members of the SLC25A carrier family become crucial checkpoints for controlling cellular energy …

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Correction: Discovery of therapeutic AGC2 modulators by combining docking, binding, and vesicle-based transport assays

Lucas Cafferati Beltrame, Sabino Todisco, Vincenzo Mangini, Elvira Bombino et autres

Following publication of the original article [1], the authors reported that “μl” was inadvertently presented as “ml” in the legend of Fig. 10. The same error has been reported for the Supplementary Material file, Figs. S10, S11, S12. Both the Figure Legend …

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Discovery of therapeutic AGC2 modulators by combining docking, binding, and vesicle-based transport assays

Lucas Cafferati Beltrame, Sabino Todisco, Vincenzo Mangini, Elvira Bombino et autres

BACKGROUD: The mitochondrial Aspartate/Glutamate Carrier 2 (AGC2), encoded by the SLC25A13 gene, plays a critical role in cellular metabolism and redox balance through the malate/aspartate shuttle. Dysregulation of AGC2 is implicated in rare genetic diseases and tumorigenesis, making it a promising therapeutic …

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Sequence/structural/functional relationships between Ganoderma fungal immunomodulatory proteins (gFIPs) and proteins involved in the modulation of immune response

Nikola Schlosserová, Jakub Treml, Maria Noemi Sgobba, Lorenzo Guerra et autres

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Apoptosis-inducing factor (AIF), dihydrolipoamide dehydrogenase (DLD), glutathione disulfide reductase (GSR), and thioredoxin reductase (TrxR) in cancer and neurological disorders: Structural insights, redox regulation, and therapeutic potential

Teresa Dipol, Mariateresa Volpicella, Stefano Loizzo, Anna Lucia Francavilla et autres

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