Nienke de Graeff

The Moral (Un)Desirability of New Biomedical Technologies as Potential Techno‐Fixes

Lieke van Kempen, Martine Charlotte de Vries, Nienke de Graeff

The techno-fix argument, used to argue against technological interventions that address the consequences of social problems instead of their underlying causes, is increasingly invoked in biomedical discussions. However, especially in biomedicine, the techno-fix argument remains conceptually underdeveloped. Therefore, in this paper, we …

nl (code pays fourni par la source)

Morally relevant features warranting ethical oversight in human stem cell-based embryo models

Naomi Moris, Alfonso Martínez Arias, Martín F. Pera, Nicolas C. Rivron et autres

gb, es, us, at, be, nl, dk (code pays fourni par la source)

Diversity-in-a-dish: A practical framework for hiPSC model development

Jesse Weidema, Hanna Lammertse, Martine Charlotte de Vries, Christine Mummery et autres

Human induced pluripotent stem cell (hiPSC) models inherit genetic and phenotypic variation from their donors that can influence differentiation, function, and disease phenotypes, with implications for model validity and generalizability. While diversity is widely discussed in biomedical research and extensively theorized in …

nl, au (code pays fourni par la source)

Beyond integration: towards benchmarks for developmental potential in human stem cell-derived embryo models

Dorian G. Luijkx, L Ashtar, Nienke de Graeff, Edith Coonen et autres

BACKGROUND: Stem cell-based embryo models (SCBEMs) are clusters of pluripotent stem cells that can mimic morphological and functional aspects of early human embryos to different degrees. When cultured from human cells, SCBEMs offer technically scalable and amenable tools that can help refine, …

nl, dk, gb (code pays fourni par la source)

The ethical aspects of human organ-on-chip models: A mapping review

Jesse Weidema, Martine de Vries, Christine L. Mummery, Nienke de Graeff

Organ-on-chips (OoCs) are controlled microfluidic platforms that replicate specific organ-level functionalities and pathological processes using cultured cells. OoCs promise to enhance drug discovery, reduce dependence on animal models, and enable personalized treatments. However, OoCs also introduce ethical challenges. This article provides a …

nl (code pays fourni par la source)

Human stem cell-based embryo models: innovation, ethics, and policy.

Alfonso Martínez Arias, Nicolas C. Rivron, Shahragim Tajbakhsh, Josephine Johnston et autres

Acknowledgements: We are grateful to the Institute Pasteur for hosting the meeting that led to this paper and Doug Sipp for contributions to the initial discussions and the kickoff meeting that informed the early development of this manuscript.

es, bg, fr, jp, ch, gb, cn, sa, us, nl, dk, il, in, se, au, be, at (code pays fourni par la source)

Views of male childhood cancer survivors on fertility preservation and restoration

Jillis van Maaren, Nienke de Graeff, Jaap G. den Hartogh, Alied M. van der Aa‐van Delden et autres

Abstract: In this study, we aimed to uncover the perspectives of male childhood cancer survivors on parenthood, fertility preservation, and potential fertility restoration using their own cryopreserved testicular biopsy. We invited all young men eligible for this study, 27 male cancer survivors …

nl, dk (code pays fourni par la source)

From image to infrastructure: reframing identity production in digital twins

Jesse Weidema, Martine Charlotte de Vries, Nienke de Graeff

nl (code pays fourni par la source)

60PStakeholder perspectives on the development of an intramuscular CRISPR/Cas9 based gene editing therapy (GET) for Duchenne muscular dystrophy

Isabelle Pirson, Nienke de Graeff, Marc de Vries, Erik Harmen Niks

nl (code pays fourni par la source)

Ethical considerations of disclosure of iatrogenic cerebral amyloid angiopathy

Kanishk Kaushik, Marleen M. Eijkholt, Nienke de Graeff, Gargi Banerjee et autres

Cerebral amyloid angiopathy (CAA) causes stroke and cognitive decline. The recently identified iatrogenic CAA subtype (iCAA) is thought to be transmitted through medical procedures involving cadaveric human material and potentially neurosurgical instruments or blood transfusions. This raises ethical questions concerning disclosure of …

nl, gb (code pays fourni par la source)

Who should be included in first-in-human trials? A systematic review of reasons

Lieke van Kempen, Martine Charlotte de Vries, Eelco J.P. de Koning, Nienke de Graeff

BACKGROUND: First-in-human trials mark a significant turning point in translational research, with novel therapies being tested in humans for the first time. Who should be included in FIH trials is a topic of ongoing debate amongst researchers, clinicians, ethicists, and sponsors. Yet, …

nl (code pays fourni par la source)

On the moral (in)equivalence of human embryos and stem cell-derived embryo models

Nienke de Graeff, Lien De Proost

Gyngell et al argue that no intrinsic differences exist between stem cell-derived embryo models (SCEMs) and embryos derived from fertilisation that would justify attributing a higher moral status to the latter. Consequently, they claim there is no ethical rationale for treating SCEMs …

nl (code pays fourni par la source)