Naomi Moris

Morally relevant features warranting ethical oversight in human stem cell-based embryo models

Naomi Moris, Alfonso Martínez Arias, Martín F. Pera, Nicolas Rivron et autres

gb, es, us, at, be, nl, dk (code pays fourni par la source)

A guide to using embedded ethics in human stem-cell-based embryo model research

Heidi Beate Bentzen, Maxence Gaillard, Iftach Nachman, Daniel Reumann et autres

no, be, il, gb, fr, se, at, us, de (code pays fourni par la source)

Modelling co-development between the somites and neural tube in human trunk-like structures

Komal Makwana, Louise Tilley, Probir Chakravarty, Jamie Thompson et autres

Human stem cell-based embryo models provide experimentally amenable in vitro systems for developmental research. A key feature of embryo models is their multi-lineage differentiation, which allows for the study of tissue co-development. Here we develop human trunk-like structures that have morphologically organized …

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Human stem cell-based embryo models: innovation, ethics, and policy.

Alfonso Martínez Arias, Nicolas Rivron, Shahragim Tajbakhsh, Josephine Johnston et autres

Acknowledgements: We are grateful to the Institute Pasteur for hosting the meeting that led to this paper and Doug Sipp for contributions to the initial discussions and the kickoff meeting that informed the early development of this manuscript.

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[PEER REVIEWED] Generation of human Trunk-like Structures (hTLS) from Human Pluripotent Stem Cells v1

Komal Makwana, Louise Tilley, Jamie Thompson, Ignacio Rodríguez-Polo et autres

Novel in vitro approaches are required to overcome the technical and ethical challenges associated with studying human embryogenesis. 3D stem cell-based embryo models are providing new insights on human biology from cultures of human pluripotent stem cells (hPSCs). This protocol describes the …

gb (code pays fourni par la source)

Modelling co-development between the somites and neural tube in human Trunk-like Structures (hTLS)

Komal Makwana, Louise Tilley, Probir Chakravarty, Jamie Thompson et autres

Human stem cell-based embryo models have opened new avenues of research in development by providing experimentally amenable in vitro systems. One of the features of embryo models is their multilineage differentiation, which allows the co-development of, and interactions between, tissues. Here, we …

gb (code pays fourni par la source)

Criteria for the standardization of stem-cell-based embryo models

Alfonso Martínez Arias, Nicolas Rivron, Naomi Moris, Patrick Tam et autres

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Using Embryo Models to Understand the Development and Progression of Embryonic Lineages: A Focus on Primordial Germ Cell Development

Ignacio Rodríguez-Polo, Naomi Moris

BACKGROUND: Recapitulating mammalian cell type differentiation in vitro promises to improve our understanding of how these processes happen in vivo, while bringing additional prospects for biomedical applications. The establishment of stem cell-derived embryo models and embryonic organoids, which have experienced explosive growth …

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Vitamin K: missed at peril—the case for extra supplementation to prevent deficiency in breastfed preterm infants

Paul Clarke, Nicholas D. Embleton, Mary Fewtrell, Dominic J. Harrington et autres

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Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity

Hyung Chul Lee, Nidia M. M. Oliveira, Cato Hastings, Adam A. Moverley et autres

Many amniote vertebrate species including humans can form identical twins from a single embryo, but this only occurs rarely. It has been suggested that the primitive-streak-forming embryonic region emits signals that inhibit streak formation elsewhere but the signals involved, how they are …

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Author Correction: Changing the public perception of human embryology

Nicolas Rivron, Alfonso Martínez Arias, Karen Sermon, Christine L. Mummery et autres

at, es, be, nl, de, us, gb, ca, jp (code pays fourni par la source)

Changing the public perception of human embryology

Nicolas Rivron, Alfonso Martínez Arias, Karen Sermon, Christine L. Mummery et autres

at, es, be, nl, de, us, gb, ca, jp (code pays fourni par la source)