Adam S. Haberman

Abstract 2525 Integrating Molecular and Cellular Biology Tools in Malate Dehydrogenase (MDH) CUREs

Joseph John Provost, Tia L. Walker, Sue Ellen DeChenne‐Peters, Celeste N. Peterson et autres

Course-based undergraduate research experiences (CUREs) are transformative for engaging students. This poster showcases the integration of advanced cellular and molecular biology tools in undergraduate courses, enabling students to investigate the biochemical and physiological roles of malate dehydrogenase (MDH) across diverse systems. Students …

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Genetics of MDH in humans

Adam S. Haberman, Celeste N. Peterson

Malate dehydrogenase (MDH) performs key roles in metabolism, but little is known about its function specifically in human health and disease. In this minireview, we describe the incomplete state of our knowledge of human MDH genetics. Humans have three MDH genes with …

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Supporting the democratization of science during a pandemic: genomics Course-based Undergraduate Research Experiences (CUREs) as an effective remote learning strategy

David E. Lopatto, S. Catherine Silver Key, Melanie Van Stry, Jamie L. Siders et autres

ABSTRACT The initial phase of the COVID-19 pandemic changed the nature of course delivery from largely in-person to exclusively remote, thus disrupting the well-established pedagogy of the Genomics Education Partnership (GEP; https://www.thegep.org ). However, our web-based research adapted well to the remote …

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Student Attitudes Contribute to the Effectiveness of a Genomics CURE

David E. Lopatto, Anne Rosenwald, Rebecca C. Burgess, Catherine Silver Key et autres

The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work …

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Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience

David E. Lopatto, Anne Rosenwald, Justin R. DiAngelo, Amy T. Hark et autres

A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability is essential to being a successful scientist, but replicating such challenges in a teaching setting can be difficult. The Genomics Education Partnership (GEP) …

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Polyglutamine repeat proteins disrupt actin structure in Drosophila photoreceptors

Annie Vu, Tyler J. Humphrey, Sean Vogel, Adam S. Haberman

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Retrotransposons Are the Major Contributors to the Expansion of theDrosophila ananassaeMuller F Element

Wilson Leung, Christopher D. Shaffer, Elizabeth J. Chen, Thomas J Quisenberry et autres

Abstract The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (>18.7 Mb) in D. …

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Phosphorylation of Neuronal Proteins in Drosophila melanogaster Changes With Age

Alexis N. Thomas, Adam S. Haberman

Cells, such as epithetical and red blood cells, have the capacity to regenerate throughout an organism's lifetime. However, neurons are unique because they do not regenerate; once most neurons are formed, they last the lifetime of an organism. This lack of regeneration …

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DrosophilaMuller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

Wilson Leung, Christopher D. Shaffer, Laura K Reed, Sheryl T. Smith et autres

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence …

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A Central Support System Can Facilitate Implementation and Sustainability of a Classroom-Based Undergraduate Research Experience (CURE) in Genomics

David E. Lopatto, Charles R. Hauser, Christopher J. Jones, Don W. Paetkau et autres

In their 2012 report, the President's Council of Advisors on Science and Technology advocated "replacing standard science laboratory courses with discovery-based research courses"-a challenging proposition that presents practical and pedagogical difficulties. In this paper, we describe our collective experiences working with the …

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A Course-Based Research Experience: How Benefits Change with Increased Investment in Instructional Time

Christopher D. Shaffer, Consuelo J. Alvarez, April Elaine Bednarski, David Dunbar et autres

There is widespread agreement that science, technology, engineering, and mathematics programs should provide undergraduates with research experience. Practical issues and limited resources, however, make this a challenge. We have developed a bioinformatics project that provides a course-based research experience for students at …

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Neuronal synaptobrevinpromotes longevity in Drosophila photoreceptors

Jonathan Mejia, Adam S. Haberman

Neurons have unique challenges relative to other cell types. Unlike most other cells, neurons must remain healthy and functional throughout the lifespan of an animal. Premature neuronal loss underlies many age-related neurodegenerative diseases, including Alzheimer and Parkinson Diseases. Despite previous research aimed …

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