Takashi Hashimoto

IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes

Lei Bao, Christian Fernando Guerrero‐Juarez, Jing Li, Manuela Pigors et autres

Autoantibodies in bullous pemphigoid (BP) are known to activate the innate immune response. Nevertheless, the direct effect of autoantibodies on keratinocytes and the contribution of keratinocyte responses to the pathology of BP are largely unknown. Here, by performing multiplex immunoassays and RNA-seq …

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A Case of Granular C3 Dermatosis With Methemoglobinemia After Administration of Dapsone

Yutaka Inaba, Chiharu Tateishi, Takashi Hashimoto, Masatoshi Jinnin

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

jp (code pays fourni par la source)

Diagnostic methods and strategies for autoimmune bullous diseases

Hua Qian, Norito Ishii, Hiroshi Koga, Kwesi Teye et autres

INTRODUCTION: Autoimmune bullous disease (AIBD), showing blistering lesions on the skin and/or mucous membranes, is characterized by autoantibodies against various structural molecules present in keratinocyte cell surfaces and epidermal basement membrane zone. In addition to the clinical and pathological features, identification of …

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Activities of the Research Group for Comprehensive Research of Gene Mutation-related Rare and Intractable Diseases of the Skin within the Project for Research on Intractable Diseases of the Ministry of Health, Labor, and Welfare of Japan

Takashi Hashimoto, Shinichi Moriwaki, Hiroaki Iwata, Minao Furumura et autres

The Hashimoto Research Group for Comprehensive Research of Gene Mutation-related Rare and Intractable Diseases of the Skin is a contributor to the Project for Research on Intractable Diseases of the Ministry of Health, Labor, and Welfare (MHLW) of Japan. Our research group …

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Involvement of KATANIN1, a microtubule-severing enzyme, in hypergravity-induced modification of growth anisotropy in Arabidopsis hypocotyls

Takayuki Hattori, Sayoko Hishii-Higuchi, Hiroko Inoue, T. KATO et autres

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Natural and induced variations in transcriptional regulator genes result in low‐nicotine phenotypes in tobacco

Tsubasa Shoji, Koki Moriyama, Nicolas Sierro, Sonia Ouadi et autres

In tobacco, the homologous ETHYLENE RESPONSE FACTOR (ERF) transcription factors ERF199 and ERF189 coordinate the transcription of multiple metabolic genes involved in nicotine biosynthesis. Natural alleles at the NIC1 and NIC2 loci greatly affect alkaloid accumulation and overlap with ERF199 and ERF189 …

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Two Kinesin-14A Motors Oligomerize to Drive Poleward Microtubule Convergence for Acentrosomal Spindle Morphogenesis in Arabidopsis thaliana

Takashi Hotta, Yuh‐Ru Julie Lee, Takumi Higaki, Takashi Hashimoto et autres

Plant cells form acentrosomal spindles with microtubules (MTs) converged toward two structurally undefined poles by employing MT minus end-directed Kinesin-14 motors. To date, it is unclear whether the convergent bipolar MT array assumes unified poles in plant spindles, and if so, how …

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Bullous pemphigoid and milia: prevalence and clinical laboratory findings in a Brazilian sample

Sebastián Vernal, Ederson Valei Lopes de Oliveira, Roberto Bueno Filho, Tamíris Amanda Júlio et autres

BACKGROUND: Bullous pemphigoid (BP) associated with milia lesions has been increasingly reported, but its prevalence has not been reported in a Brazilian BP population yet. OBJECTIVES: To describe the occurrence and clinical-laboratorial findings of BP-milia association in a southeastern Brazilian sample. METHODS: …

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Suppression of Cortical Microtubule Reorientation and Stimulation of Cell Elongation in Arabidopsis Hypocotyls under Microgravity Conditions in Space

Shiho Kato, Mana Murakami, Ryo Saika, Kouichi Soga et autres

How microgravity in space influences plant cell growth is an important issue for plant cell biology as well as space biology. We investigated the role of cortical microtubules in the stimulation of elongation growth in Arabidopsis (Arabidopsis thaliana) hypocotyls under microgravity conditions …

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Hyperosmotic stress-induced microtubule disassembly in Chlamydomonas reinhardtii

Lee Mei Ng, Shinichiro Komaki, Hideyuki Takahashi, Takashi Yamano et autres

BACKGROUND: Land plants respond to drought and salinity by employing multitude of sophisticated mechanisms with physiological and developmental consequences. Abscisic acid-mediated signaling pathways have evolved as land plant ancestors explored their habitats toward terrestrial dry area, and now play major roles in …

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Finding a right place to cut: How katanin is targeted to cellular severing sites

Masayoshi Nakamura, Noriyoshi Yagi, Takashi Hashimoto

Microtubule severing by katanin plays key roles in generating various array patterns of dynamic microtubules, while also responding to developmental and environmental stimuli. Quantitative imaging and molecular genetic analyses have uncovered that dysfunction of microtubule severing in plant cells leads to defects …

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Suppression of secondary wall formation in the basal supporting region of Arabidopsis inflorescence stems under microgravity conditions in space

Yusuke Tanimura, Atsushi Mabuchi, Kouichi Soga, Kazuyuki Wakabayashi et autres

We conducted the Resist Tubule space experiment to clarify the role of the cell wall in the resistance of inflorescence stems of Arabidopsis (Arabidopsis thaliana) to gravitational acceleration in the Cell Biology Experiment Facility on the Kibo Module of the International Space …

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