Balaji Krishnan

Regional Neuroinflammatory Responses to Severe Burn-Induced Systemic Inflammation and Physiological Stress

Cutler Cannon, Sanjana Mohanty, Shaneilahi Budhwani, Gopalkrishnashetty Sreenivasmurthy Sravan et autres

Immediate post-injury HMGB1 neutralization prevents synaptic dysfunction in burn and hindlimb unloaded rats

Sravan Gopalkrishna Shetty Sreenivasa Murthy, Gábor Törő, Allison Wyrick, Amina El Ayadi et autres

Introduction: Severe burns are known to provoke neuroinflammation and contribute to cognitive deficits, but the mechanism of action remains poorly understood. We hypothesize that early release of extracellular high mobility group box 1 (HMGB1), a key driver for inflammation, triggers the burn-induced …

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Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

Aditya Kumar Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan Michael Dvorak et autres

BACKGROUND AND PURPOSE: Kinases phosphorylate ion channels, but their noncatalytic roles via protein-protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents …

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Exofection as a Therapeutic Modality: Restoring P-gp Activity via Trophoblast-Derived EV in Neuroinflammatory Disorders

Ananth Kumar Kammala, Madhuri Tatiparthy, Sahana S. Murthy, Klarissa H Garza et autres

Background: P-glycoprotein (P-gp/ABCB1) is a key efflux transporter that maintains barrier integrity by clearing xenobiotics and toxic metabolites. At the feto-maternal interface, trophoblast-derived extracellular vesicles (CTC-EVs) naturally and transiently transfer functional P-gp to maternal decidual cells, restoring lost and or reduced P-gp …

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Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases

Anirban Chakraborty, Joy Mitra, Vikas H. Malojirao, Manohar Kodavati et autres

TDP-43 proteinopathy is central to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 plays a key role in DNA double-strand break repair (DSBR), though the underlying mechanisms remain unclear. Here, we demonstrate that ALS patients’ brains exhibit persistent DNA damage within …

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PLD1-Dependent Regulation of Synaptic Integrity: Implications for Cognitive Resilience and Alzheimer’s Disease Pathogenesis

Shaneilahi M. Budhwani, Poonam Shah, Chandramouli Natarajan, Karthik Ramaswamy et autres

Dysregulation of Phospholipase D1 (PLD1) has been implicated in the progression of neurodegenerative diseases, including Alzheimer's Disease (AD). This study investigated PLD1 signaling in synaptic integrity and cognition during aging and in a late-onset AD mouse model, hypothesizing differential effects of PLD1 …

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The impact of peripheral burn insult on the central nervous system

Juquan Song, Balaji Krishnan, Nisha Jain Garg

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Exosome-Mediated Delivery of a PLD1 Modulator Overcomes Bioavailability Hurdles to Target Synaptopathy in Neurodegenerative Diseases

Shaneilahi M. Budhwani, Sravan Gopalkrishna Shetty Sreenivasamurthy, Klarissa H Garza, Pilar Flores‐Espinosa et autres

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Hippocampal Neural Stem Cell Exosomes Promote Brain Resilience against the Impact of Tau Oligomers

Balaji Krishnan, Michela Marcatti, Anna Fracassi, Wen-Ru Zhang et autres

A promising therapeutic intervention for preventing the onset and progression of Alzheimer's disease is to protect and improve synaptic resilience, a well-established early vulnerability associated with the toxic effects of oligomers of amyloid β (AβO) and Tau (TauO). We have previously reported …

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Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia

Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan et autres

Preeclampsia (preE) is a severe multisystem hypertensive syndrome of pregnancy associated with ischemia/hypoxia, angiogenic imbalance, apolipoprotein E (ApoE)-mediated dyslipidemia, placental insufficiency, and inflammation at the maternal-fetal interface. Our recent data further suggest that preE is associated with impaired autophagy, vascular dysfunction, and …

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Genotype-Specific Electroretinogram Signatures in Drosophila : Implications for Neurodegeneration Models Using w 1118 Backgrounds

Malav Mallipudi, Arya Gajwani, Daniel C. Jupiter, Balaji Krishnan

Abstract Drosophila melanogaster serves as a powerful model for studying neurodegenerative diseases, often employing the GAL4-UAS system for targeted gene expression. Electroretinograms (ERGs) provide a robust in vivo functional readout of neuronal integrity and are increasingly used to assess disease progression and …

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Functional assessment of Phospholipase D1 using wild‐type, transgenic AD mice, and human spheroid models: A spatial and temporal mechanism for the progression of neurodegeneration

Chandramouli Natarajan, Klarissa H Garza, Shaneilahi M. Budhwani, Sarah Bosworth et autres

BACKGROUND: Alzheimer's disease (AD) is the memory-related neurodegenerative disorder, contributing to 70% of the cases globally. Synaptic dysfunction is a well-known early event that causes progressive cognitive decline in AD. The latest AD therapeutics on the forefront only offer a moderate symptomatic …

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