Accès ouvert
2026
article
OpenAlex
Kristine Knappskog, Julia Kleinhapl, Titas Gladkauskas, Siren Fromreide et autres
Background: Norepinephrine is commonly used during acute burn resuscitation to maintain adequate perfusion pressure. However, its effects, together with the burn-induced catecholamine surge, on arterial α1-adrenergic receptors (α1-AR) remain unclear. This study examined whether burn injury and continuous norepinephrine infusion alter arterial …
no, us, at
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2026
article
OpenAlex
Kristine Knappskog, Kostiantyn Botnar, Julia Kleinhapl, Juquan Song et autres
The data that support the findings of the original article to which this commentary responds, and the additional data shared in this letter, were obtained from the US Collaborative Network within the TriNetX Research Network (Network Name: Research (with NLP)). The data …
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Accès ouvert
2026
article
OpenAlex
Sravan Gopalkrishna Shetty Sreenivasa Murthy, Gábor Törő, Allison M Wyrick, Amina El Ayadi et autres
Introduction: Severe burns are known to provoke neuroinflammation and contribute to cognitive deficits, but the mechanism of action remains poorly understood. We hypothesize that early release of extracellular high mobility group box 1 (HMGB1), a key driver for inflammation, triggers the burn-induced …
us
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2026
article
OpenAlex
Isabelle Bergman, Julia Kleinhapl, Neha Sunkara, Amina El Ayadi
The use of single-cell RNA sequencing and spatial transcriptomics has recently challenged and refined concepts in the field of wound healing by enabling detailed characterisation of cellular heterogeneity while providing spatial context. Previously used separately, these methods are now increasingly applied together …
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2026
letter
OpenAlex
Blancheneige M Beohon, Amina El Ayadi, Steven Wolf, Juquan Song
Dear Editor, We thank the authors for their thoughtful commentary on our study, “Evaluating ChatGPT’s Utility in Addressing Socioeconomic Disparities in Burn Patients: A Comparative Study With Google.” We appreciate their engagement with our work and their emphasis on the distinction between …
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Accès ouvert
2026
article
OpenAlex
Julia Kleinhapl, Juquan Song, Ye Wang, Kan Nakamoto et autres
Background and Objectives: Burn wounds are associated with delayed healing, infection, and pathological scarring. Effective repair requires tightly regulated immune and oxidative stress responses, including macrophage polarization. This study evaluated the association of the photosensitizer Rose Bengal, delivered in a hydrogel vehicle, …
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Accès ouvert
2026
article
OpenAlex
Sudhanvan Iyer, Joshua Wang, Philong Nguyen, Aidan R Carroll et autres
Abstract Introduction Paediatric burns are common traumatic injuries experienced during childhood. In addition to the immediate medical challenges of wound healing, these children are at risk for long-term psychosocial consequences associated with pain, prolonged hospitalization, and social stigmatization. While the psychological aftermath …
us
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2026
article
OpenAlex
Juquan Song, Gábor Törő, Amina El Ayadi, Steven E Wolf et autres
INTRODUCTION: Prolonged immobilization worsens the patient's recovery following severe burn injury and results in a prolonged hospitalization. This study aims to assess the alterations in bone mineral density and body composition in a pre-clinical model of cutaneous burn combined with immobilization. METHODS: …
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Accès ouvert
2026
article
OpenAlex
Kristine Knappskog, Kostiantyn Botnar, Julia Kleinhapl, Juquan Song et autres
ABSTRACT Background Vasopressors are often introduced in severe burn patients who respond poorly to fluid resuscitation to maintain adequate blood pressure and avoid fluid creep . This study aims to characterise these patients and explore potential correlations between vasopressor use and patient …
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Accès ouvert
2025
article
OpenAlex
Sean T. O’Leary, Anesh Prasai, Ariadna Robledo, Christopher Thang et autres
Background: Severe burn injuries can cause long-term cognitive impairments, potentially driven by lipid-mediated neuroinflammation in the central nervous system (CNS). The disruption of lipid homeostasis may contribute to neuroinflammatory responses, exacerbating neuronal damage. This study investigates whether acipimox, an anti-lipolytic agent, modulates …
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Accès ouvert
2025
article
OpenAlex
S. Lee, Allison M Wyrick, Amina El Ayadi, Steven E. Wolf et autres
Severe burns trigger hyperinflammatory and hypermetabolic responses, leading to systemic organ damage. High mobility group box 1 (HMGB1) is an inflammatory peptide released from injured sites. This study investigated wound progression in scald burn rats treated with anti-HMGB1 antibody (Ab). Male Sprague-Dawley …
us
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2025
article
OpenAlex
Matthew Q Dao, Pratik Vangal, Keisha E. Montalmant, C Meléndez et autres
Facial burns can cause profound psychological distress, often treated with selective serotonin reuptake inhibitors or serotonin-norepinephrine reuptake inhibitors. While their psychiatric benefits are established, their impact on wound healing and long-term outcomes is less defined. This study examines associations between early serotonergic …
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