Masafumi Takaji

Medial premotor cortex as a potential reservoir of reward expectancy signals influencing the primate frontoparietal network

Keisuke Sehara, Masashi Kondo, Yuka Hirayama, Teppei Ebina et autres

Reward expectancy plays an important role in modulating cortical activity associated with motivation, selection, and preparation of subsequent goal-directed movements. However, it is unclear how it is represented in the primate frontoparietal cortex in a form that is separable from activity for …

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Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex

Keisuke Sehara, Masashi Kondo, Yuka Hirayama, Teppei Ebina et autres

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective of whether the movements are task-relevant or task-irrelevant. To examine the extent to which movements and a primitive cognitive signal, i.e., reward expectancy, modulate the …

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Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning

Teppei Ebina, Akitaka Sasagawa, Dokyeong Hong, Rieko Setsuie et autres

Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor cortex (M1). To reveal PM- and M1-specific reorganization in a primate, we conducted calcium imaging in common marmosets while they learned a two-target reaching (pull/push) task after …

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Change detection in the primate auditory cortex through feedback of prediction error signals

Keitaro Obara, Teppei Ebina, Shin-Ichiro Terada, Takanori Uka et autres

Although cortical feedback signals are essential for modulating feedforward processing, no feedback error signal across hierarchical cortical areas has been reported. Here, we observed such a signal in the auditory cortex of awake common marmoset during an oddball paradigm to induce auditory …

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Dynamics of motor direction representation in the primate premotor and primary motor cortices during sensorimotor learning

Teppei Ebina, Akitaka Sasagawa, Dokyeong Hong, Rieko Setsuie et autres

Summary Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor cortex (M1). However, how PM- and M1-specific reorganization occurs in primates remains unclear. We conducted calcium imaging of these areas in common marmosets while they learned …

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Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

Akiya Watakabe, Henrik Skibbe, Ken Nakae, Hiroshi Abe et autres

The prefrontal cortex (PFC) has dramatically expanded in primates, but its organization and interactions with other brain regions are only partially understood. We performed high-resolution connectomic mapping of the marmoset PFC and found two contrasting corticocortical and corticostriatal projection patterns: "patchy" projections …

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ドーパミン系ストレス負荷に伴う統合失調症発症仮説のマーモセットへの適用可能性

三佐子 小松, Misako Komatsu, Masafumi Takaji, Tetsuo Yamamori

Local and long-distance organization of prefrontal cortex circuits in the marmoset brain

Akiya Watakabe, Henrik Skibbe, Ken Nakae, Hiroshi Abe et autres

Summary Prefrontal cortex (PFC) has dramatically expanded in primates, but its organization and interactions with other brain regions are only partially understood. We performed high-resolution connectomic mapping of marmoset PFC and found two contrasting corticocortical and corticostriatal projection patterns: “patchy” projections that …

jp, us (code pays fourni par la source)

Arm movements induced by noninvasive optogenetic stimulation of the motor cortex in the common marmoset

Teppei Ebina, Keitaro Obara, Akiya Watakabe, Yoshito Masamizu et autres

Optogenetics is now a fundamental tool for investigating the relationship between neuronal activity and behavior. However, its application to the investigation of motor control systems in nonhuman primates is rather limited, because optogenetic stimulation of cortical neurons in nonhuman primates has failed …

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Distinct roles for primate caudate dopamine D1 and D2 receptors in visual discrimination learning revealed using shRNA knockdown

Masafumi Takaji, Atsushi Takemoto, Chihiro Yokoyama, Akiya Watakabe et autres

The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation exists …

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Application of viral vectors to the study of neural connectivities and neural circuits in the marmoset brain

Akiya Watakabe, Osamu Sadakane, Katsusuke Hata, Masanari Ohtsuka et autres

It is important to study the neural connectivities and functions in primates. For this purpose, it is critical to be able to transfer genes to certain neurons in the primate brain so that we can image the neuronal signals and analyze the …

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Long-Term Two-Photon Calcium Imaging of Neuronal Populations with Subcellular Resolution in Adult Non-human Primates

Osamu Sadakane, Yoshito Masamizu, Akiya Watakabe, Shin-Ichiro Terada et autres

Two-photon imaging with genetically encoded calcium indicators (GECIs) enables long-term observation of neuronal activity in vivo. However, there are very few studies of GECIs in primates. Here, we report a method for long-term imaging of a GECI, GCaMP6f, expressed from adeno-associated virus …

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