Akiya Watakabe

Medial premotor cortex as a potential reservoir of reward expectancy signals influencing the primate frontoparietal network

Keisuke Sehara, Masashi Kondo, Yuka Hirayama, Teppei Ebina et autres

Reward expectancy plays an important role in modulating cortical activity associated with motivation, selection, and preparation of subsequent goal-directed movements. However, it is unclear how it is represented in the primate frontoparietal cortex in a form that is separable from activity for …

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Intrinsic elaboration of prefrontal modularity: a dual-control model of axon bundling and synaptic docking

Tetsuo Yamamori, Akiya Watakabe, Henrik Skibbe

The evolutionary expansion of the primate prefrontal cortex (PFC) presents a profound biological enigma: how does this region achieve a highly ordered, modular architecture in the absence of direct dense sensory templates that govern primary sensory areas? In this review, we synthesize …

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Memory efficient training for 3D brain image registration networks using PatchMorph

Henrik Skibbe, Michal Byra, Akiya Watakabe, Tetsuo Yamamori et autres

We present PatchMorph, a novel stochastic framework designed to significantly reduce memory demand during training and inference of existing unsupervised convolutional and transformer-based registration networks for 3D brain image registration. PatchMorph extends existing methods to handle global registration tasks that are impractical …

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Code and dataset for: CRTC1 knockdown disrupts cortical homeostasis and induces widespread IEG expression in the marmoset visual cortex

Yuki Nakagami, Misako Komatsu, Ken Nakae, Masanari Otsuka et autres

This repository provides the dataset and analysis code used in the study:Nakagami et al., "CRTC1 knockdown disrupts cortical homeostasis and induces widespread immediate early gene expression in the marmoset visual cortex", Neuroscience Research (in press).The repository contains the cleaned hemisphere-level dataset and …

CRTC1 knockdown in the marmoset visual cortex induces neuronal IEG overexpression, HFOs, and neurodegeneration

Yuki Nakagami, Misako Komatsu, Ken Nakae, Masanari Ohtsuka et autres

CRTC1 is highly expressed in the brain and functions as a coactivator of CREB, regulating transcription of genes essential for neuronal function and plasticity. To elucidate its role in the primate cortex, we performed CRTC1 knockdown using short hairpin RNA (shRNA) in …

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Code and dataset for: CRTC1 knockdown disrupts cortical homeostasis and induces widespread IEG expression in the marmoset visual cortex

Yuki Nakagami, Misako Komatsu, Ken Nakae, Masanari Otsuka et autres

This repository provides the dataset and analysis code used in the study:Nakagami et al., "CRTC1 knockdown disrupts cortical homeostasis and induces widespread immediate early gene expression in the marmoset visual cortex", Neuroscience Research (in press).The repository contains the cleaned hemisphere-level dataset and …

An evolutionary view on the developing prefrontal cortex connectome and its psychopathological networks: Tract tracing and imaging studies linking two distant anthropoid species

Volker A. Coenen, Alexander Rau, Akiya Watakabe, Henrik Skibbe et autres

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Visualization of Selective Neural Pathways by Double Viral Infection Method

Akiya Watakabe

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Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

Akiya Watakabe, Toshiki Tani, Hiroshi Abe, Henrik Skibbe et autres

Serial Two-photon tomography (STPT) is a technique to image a mass of tissue in its three-dimensional shape by combining two-photon imaging with automatic stage control and microtome slicing. We successfully implemented this technique for tracing the axonal projections in the marmoset brain. …

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Serial Two-Photon Tomography Imaging of the whole marmoset brain for neuroanatomical analyses

Akiya Watakabe, Toshiki Tani, Hiroshi Abe, Henrik Skibbe et autres

ABSTRACT Serial Two photon tomography (STPT) imaging is a technique to image a mass of tissue in its three-dimensional shape by combining two-photon imaging with automatic stage control and microtome slicing. We successfully implemented this technique for tracing the axonal projections in …

jp (code pays fourni par la source)

Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex

Keisuke Sehara, Masashi Kondo, Yuka Hirayama, Teppei Ebina et autres

Abstract Neural activity across the dorsal neocortex of rodents is dominated by orofacial and limb movements, irrespective of whether the movements are task-relevant or task-irrelevant. To examine the extent to which movements and a primitive cognitive signal, i.e., reward expectancy, modulate the …

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Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning

Teppei Ebina, Akitaka Sasagawa, Dokyeong Hong, Rieko Setsuie et autres

Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor cortex (M1). To reveal PM- and M1-specific reorganization in a primate, we conducted calcium imaging in common marmosets while they learned a two-target reaching (pull/push) task after …

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