2026
article
OpenAlex
Estevan Cleveland, Aiden R. Wolf, Shawn Chen, Farhana Afrin Mohona et autres
Abstract Nanodiscs are nanoscale lipid bilayer membrane mimetics surrounded by two membrane scaffold proteins (MSPs). They are widely used as soluble cassettes for membrane proteins and lipids in diverse applications in structural, functional, and biophysical studies. The original MSP was derived directly …
us
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Accès ouvert
2026
preprint
OpenAlex
Estevan Cleveland, A. A. Wolf, Shawn Chen, Farhana Afrin Mohona et autres
Nanodiscs are nanoscale lipid bilayer membrane mimetics surrounded by two membrane scaffold proteins (MSP). They are widely used as soluble cassettes for membrane proteins and lipids in diverse applications in structural, functional, and biophysical studies. The original MSP was derived directly from …
us
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2025
other
OpenAlex
Hiruni S. Jayasekera, Farhana Afrin Mohona, Michael Thomas Marty
Membrane proteins are about 30% of the human proteome and serve important physiological roles, including chemical transport, cell signaling, and energy transduction. Consequently, they represent about half of all drug targets. Small molecule drugs have been most commonly used to target membrane …
us
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Accès ouvert
2025
article
OpenAlex
Hiruni S. Jayasekera, Farhana Afrin Mohona, Madison J. De Jesus, Michael Thomas Marty
Lipids surrounding membrane proteins interact with different sites on the protein with varying specificities, ranging from highly specific to weak interactions. These interactions can modulate the structure, function, and stability of membrane proteins. Thus, to better understand membrane protein structure and function, …
us
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Accès ouvert
2024
preprint
OpenAlex
Hiruni S. Jayasekera, Farhana Afrin Mohona, Madison J. De Jesus, Michael Thomas Marty
Lipids surrounding membrane proteins interact with different sites on the protein at varying specificities, ranging from highly specific to weak interactions. These interactions can modulate the structure, function, and stability of membrane proteins. Thus, to better understand membrane protein structure and function, …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Hiruni Jayasekera, Farhana Afrin Mohona, Michael Thomas Marty
Membrane proteins are about 30% of the human proteome and serve important physiological roles, including chemical transport, cell signaling, and energy transduction. Consequently, they represent about half of all drug targets. Small molecule drugs have been most commonly used to target membrane …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Hiruni S. Jayasekera, Farhana Afrin Mohona, Megan A. Ewbank, Michael Thomas Marty
Lipids are critical modulators of membrane protein structure and function. However, it is challenging to investigate the thermodynamics of protein-lipid interactions because lipids can simultaneously bind membrane proteins at different sites with different specificities. Here, we developed a native mass spectrometry (MS) …
us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Hiruni S. Jayasekera, Farhana Afrin Mohona, Megan A. Ewbank, Michael Thomas Marty
Lipids are critical modulators of membrane protein structure and function. However, it is challenging to investigate the thermodynamics of protein-lipid interactions because lipids can simultaneously bind membrane proteins at different sites with different specificities. Here, we developed a native mass spectrometry (MS) …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Md Shamiul Islam Rasel, Farhana Afrin Mohona, Dilshad Noor Lira, Uttom Kumar et autres
Inadequate resources and a fragmented healthcare system in Bangladesh lead to the practice of almost non-reporting of adverse drug reactions (ADR). Pharmacists may offer service in this regard to strengthen pharmacovigilance if given the appropriate opportunity. To evaluate their preparedness, the current …
bd
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Accès ouvert
2022
article
OpenAlex
Md Shamiul Islam Rasel, Farhana Afrin Mohona, Wahida Akter, Shaila Kabir et autres
Cancer has been one of the most dominant causes of mortality globally over the last few decades. In cancer treatment, the selective targeting of tumor cells is indispensable, making it a better replacement for conventional chemotherapies by diminishing their adverse side effects. …
bd, us, jp, cn, sa
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