Shawn Chen

Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs

Estevan Cleveland, Aiden R. Wolf, Shawn Chen, Farhana Afrin Mohona et autres

Abstract Nanodiscs are nanoscale lipid bilayer membrane mimetics surrounded by two membrane scaffold proteins (MSPs). They are widely used as soluble cassettes for membrane proteins and lipids in diverse applications in structural, functional, and biophysical studies. The original MSP was derived directly …

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Design of Fluorescent Membrane Scaffold Proteins for Nanodiscs

Estevan Cleveland, A. A. Wolf, Shawn Chen, Farhana Afrin Mohona et autres

Nanodiscs are nanoscale lipid bilayer membrane mimetics surrounded by two membrane scaffold proteins (MSP). They are widely used as soluble cassettes for membrane proteins and lipids in diverse applications in structural, functional, and biophysical studies. The original MSP was derived directly from …

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Polysaccharide-inspired biomaterials for skeletal muscle regeneration: innovations for volumetric muscle loss treatment

Yantong Li, Jianan Chen, Shawn Chen, Xinfeng Zhou et autres

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Abstract 4339510: Human induced pluripotent stem cells derived nanovesicles for cardiomyocyte proliferation

Yuhua Wei, Xiaoxiao Geng, Qing You, Yu Zhang et autres

Background: It is well-known that cardiomyocytes (CMs) in adult mammalian hearts lose capacity to proliferate. Although cardiogenic potential of human induced-pluripotent stem-cells (hiPSCs) is well-recognized, hiPSCs cannot be administered directly due to their tumorigenicity. Acellular products that replicate the regenerative activity of …

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Seeing Across Views: Benchmarking Spatial Reasoning of Vision-Language Models in Robotic Scenes

Zhiyuan Feng, Zhaolu Kang, Qijie Wang, Zhiying Du et autres

Vision-language models (VLMs) are essential to Embodied AI, enabling robots to perceive, reason, and act in complex environments. They also serve as the foundation for the recent Vision-Language-Action (VLA) models. Yet most evaluations of VLMs focus on single-view settings, leaving their ability …

Lineage-Specific Epigenomic Mapping of Proximal and Distal Fallopian Tube Epithelium Reveals Mesenchymal/Wnt-Driven Tumor Phenotype Diversification

Liudan Wei, Huarong Wang, Wenshu Li, Jingyao Lian et autres

ABSTRACT High-grade serous ovarian cancer (HGSC) typically originates from the distal fallopian tube epithelium (disFTE), while the proximal epithelium (proFTE) remains less explored. Here, Using isogenic murine organoid models with common oncogenic drivers ( Tp53 −/− ; Kras mut ; Pten −/− …

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Microbiological evidence for the trisubstituted benzimidazoles targeting MmpL3 in Mycobacterium tuberculosis

Mengyun Zhang, R. H. Allen, Lauren Ames, Curtis A. Engelhart et autres

ABSTRACT New anti-tuberculosis (TB) drugs with novel modes of action are in great demand due to the complex treatment regimens as well as the rising number of multidrug-resistant TB cases. We recently re-evaluated a few 2,5,6-trisubstituted benzimidazole derivatives (SBZ) previously demonstrated to …

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A Low-Frequency FETD Method for Transient Coupled Electromagnetic-Thermal Simulation

Shawn Chen, Haogang Wang

In this paper, a low-frequency(LF) finite element time domain(FETD) method is proposed for solving transient coupled electromagnetic(EM)-thermal problems. It originates from the simulation of lightning effects. Considering the double-exponential waveform of lightning, with a maximum frequency of 105 Hz, it can be …

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GenVS-TBDB: A Target-Aware AI-Generated and Virtual-Screened Small-Molecule Library for Tuberculosis Drug Discovery

Xiaoying Lv, Han Jie Guo, Xi Lu, Zhuo Tang et autres

Abstract Tuberculosis (TB) remains a leading global health threat, with over 10 million new cases and 1.25 million deaths reported in 2023. Current TB therapies rely on a limited drug repertoire and prolonged treatment courses that have changed little in four decades. …

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Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Genhui Xiao, Yumeng Cui, Liangliang Zhou, Jinglan Wang et autres

Abstract The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in drug discovery research. …

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PO-06-200 COMPARISON OF DEFIBRILLATION THRESHOLDS OF THREE EV-ICD SOLUTIONS – AN IN-SILICO MODEL STUDY

Shawn Chen, Rick Sanghera, Michael P. Husby, Alan Marcovecchio et autres

Study on Thermal Runaway Propagation Characteristics and Cooling Inhibition Mechanism of Lithium-Ion Batteries

Yi Zheng, Shawn Chen, Xi Feng, Chun-Wang Ma et autres

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