Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
Rattachement africain : bd, us, jp, cn, sa. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Cancer has been one of the most dominant causes of mortality globally over the last few decades. In cancer treatment, the selective targeting of tumor cells is indispensable, making it a better replacement for conventional chemotherapies by diminishing their adverse side effects. While designing a drug to be delivered selectively in the target organ, the drug development scientists should focus on various factors such as the type of cancer they are dealing with according to which drug, targeting moieties, and pharmaceutical carriers should be targeted. All published articles have been collected regarding cancer and drug-targeting approaches from well reputed databases including MEDLINE, Embase, Cochrane Library, CENTRAL and ClinicalTrials.gov, Science Direct, PubMed, Scopus, Wiley, and Springer. The articles published between January 2010 and December 2020 were considered. Due to the existence of various mechanisms, it is challenging to choose which one is appropriate for a specific case. Moreover, a combination of more than one approach is often utilized to achieve optimal drug effects. In this review, we have summarized and highlighted central mechanisms of how the targeted drug delivery system works in the specific diseased microenvironment, along with the strategies to make an approach more effective. We have also included some pictorial illustrations to have a precise idea about different types of drug targeting. The core contribution of this work includes providing a cancer drug development scientist with a broad preliminary idea to choose the appropriate approach among the various targeted drug delivery mechanisms. Also, the study will contribute to improving anticancer treatment approaches by providing a pathway for lesser side effects observed in conventional chemotherapeutic techniques.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Exploration of Site-Specific Drug Targeting—A Review on EPR-, Stimuli-, Chemical-, and Receptor-Based Approaches as Potential Drug Targeting Methods in Cancer Treatment
- Date Crossref
- 29/09/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University of Dhaka pays non établi dans la noticeUniversité ou école supérieure
-
University of Houston pays non établi dans la noticeUniversité ou école supérieure
-
Tokushima University Department of Science & Technology pays non établi dans la noticeUniversité ou école supérieure
-
Wenzhou Medical University pays non établi dans la noticeUniversité ou école supérieure
-
Jagannath University Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
-
King Khalid University Unit of Bee Research and Honey Production pays non établi dans la noticeUniversité ou école supérieure
-
University of Barishal pays non établi dans la noticeUniversité ou école supérieure
-
Faculty of Pharmacy Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
-
College of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
-
School of Pharmaceutical Sciences Molecular Pharmacology Research Center pays non établi dans la noticeUniversité ou école supérieure
-
College of Arts and Sciences Department of Biology pays non établi dans la noticeUniversité ou école supérieure
-
Trust University Department of Biochemistry and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
University of Dhaka, University of Houston et Department of Science & Technology — Tokushima University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.