Kongzhen Hu

Heterobivalent fibroblast activation protein–targeted Radiotheranostic ligands integrating cyclic peptide and small-molecule motifs for enhanced tumor retention

Baocheng Chen, Mingming Sun, Ningjie Li, Zexin Xu et autres

cn (code pays fourni par la source)

First-in-human PET imaging of 68 Ga-FC516, a novel ACP3-targeted radiotracer for prostate cancer.

Kongzhen Hu, Ruitao Yang, Lu Wang, Huiyi Wei et autres

5128 Background: Prostatic acid phosphatase (ACP3) is overexpressed in more than 85% of prostate cancers, and largely absent in normal tissues, resulting in over 100-fold tumor-to-background specificity. ACP3 represents a differentiated imaging biomarker that may complement prostate-specific membrane antigen (PSMA), particularly in …

cn (code pays fourni par la source)

A FAP‐Targeted SMDC Platform Enables Synergistic Radionuclide–Chemotherapy with PET‐Guided Evaluation

Ruitao Yang, Hongxin Li, Zexin Xu, Baocheng Chen et autres

ABSTRACT Fibroblast activation protein (FAP) is an attractive stromal target for cancer theranostics; however, developing agents that enable non‐invasive pharmacokinetic visualization while achieving effective combined radio‐chemotherapy remains challenging. Here we report an imaging‐enabled FAP‐targeted small molecule–drug conjugate (SMDC) platform that supports PET‐based …

cn (code pays fourni par la source)

Development of CAIX-targeted radioligand theranostic pairs for clear cell renal cell carcinoma

Yang Liu, Chunwei Mo, Dong Ye, Peipei Tang et autres

cn (code pays fourni par la source)

Synthesis, evaluation and preliminary clinical study of novel 68Ga-labeled Nectin-4 targeting PET tracer

Geng Hu, Zexin Xu, Da-Yong Hou, Pengcheng Ran et autres

cn (code pays fourni par la source)

An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery

Ce Gu, Jian-You Guo, Chang Zhou, Peipei Hu et autres

Immune checkpoint blockade (ICB) therapy exerts anti-tumor efficacy mainly by activating intratumoral CD8 + T cells but fails to re-activate terminally exhausted CD8 + T cells. Interleukin-10 (IL-10) has been shown to directly expand and activate these cells and to exert a …

cn (code pays fourni par la source)

Development of novel 18F-labelled FAP-targeting tracers with improved pharmacokinetics: From preclinical optimization to clinical translation

Dan Feng, Baoyuan Li, Jiaqi Yang, Simin Peng et autres

cn (code pays fourni par la source)

Development of Cysteic Acid-Modified FAP Radioligands for Enhanced Renal Clearance: From Preclinical Optimization to First-in-Human Study

Simin Peng, Baoyuan Li, Mingming Sun, Jiaqi Yang et autres

Fibroblast activation protein (FAP)-targeting radioligands hold promise for cancer theranostics. Cyclic peptide-based DOTA-FAP-2286 radioligands have demonstrated high kidney uptake and retention, raising concerns regarding potential nephrotoxicity. Hence, we aimed to design three cysteic acid-modified FAP-targeting cyclic peptide ligands (DOTA-C1/C2/C3-FAP-2286) for reducing renal …

cn (code pays fourni par la source)

Development of ibuprofen-modified fibroblast activation protein radioligands to improve cancer therapy

Hui Zhou, Jiawei Zhong, Yang Liu, Simin Peng et autres

cn (code pays fourni par la source)

[18F]AlF-CBP imaging of type I collagen for non-invasive monitoring of pulmonary fibrosis in preclinical models

Yan Liu, Peipei Tang, Simin Peng, Jinmei Zhong et autres

cn (code pays fourni par la source)

Cerebral [18F]AIF-FAPI-42-Based PET Imaging of Fibroblast Activation Protein for Non-invasive Quantification of Fibrosis After Ischemic Stroke

Peipei Tang, Yang Liu, Simin Peng, Zhikai Cai et autres

cn (code pays fourni par la source)

Cerebral [18F]AIF-FAPI-42-based PET imaging of fibroblast activation protein for non-invasive quantification of fibrosis after ischaemic stroke

Peipei Tang, Yang Liu, Simin Peng, Zhikai Cai et autres

Abstract The development of fibrosis after injury to the brain or spinal cord limits the regeneration of the central nervous system in adult mammals. However, the extent of fibrosis in the injured brain has not been systematically investigated in mammals in vivo. …

cn (code pays fourni par la source)