Siavash Mashhouri

Spatial and functional specialization of human splenic innate lymphoid cells

Sarah J. Colpitts, Sinthuja Jegatheeswaran, Siavash Mashhouri, Ash Hagerman et autres

Secondary lymphoid organs, including the spleen, integrate innate and adaptive immune responses. Studies in murine models and humans highlight Natural Killer (NK) cells and other innate lymphoid cells (ILC) as key organizers of splenic immune activity, yet their in situ organization and …

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Cell therapy with human interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection

Sarah J. Colpitts, Sinthuja Jegatheeswaran, Amanda Oakie, Siavash Mashhouri et autres

Group 2 innate lymphoid cells (ILC2s) that produce IL-10 (IL-10 + ILC2s) have demonstrated regulatory and tissue-protective properties in murine studies, but preclinical studies are lacking that explore the potential of human IL-10 + ILC2s as a tolerance-promoting cell therapy for transplantation …

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Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model

Siavash Mashhouri, Amirhossein Rahmati, Ako Azimi, Roy A. Fava et autres

PURPOSE: Acquired resistance to immune checkpoint blockers (ICBs) is a major barrier in cancer treatment, emphasizing the need for innovative strategies. Dectin-1 (gene Clec7a) is a C-type lectin receptor best known for its ability to recognize β-glucan-rich structures in fungal cell walls. …

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A Retrospective Analysis of Leadership, Awardees, and Member Gender Representation of the Canadian Society for Immunology

Melina Messing, Dominique M. Gatti, Siavash Mashhouri, Sabryna Nantel et autres

The Canadian Society for Immunology (CSI) established a formal Equity, Diversity, and Inclusion (EDI) Committee with the goal of providing EDI advocacy and leadership within the CSI, as well as in the broader scientific community. A first task of this committee was …

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Transcriptomic profiling of peripheral blood cells in HPV ‐associated carcinoma patients receiving combined valproic acid and avelumab

Najmeh Bozorgmehr, Hussain Syed, Siavash Mashhouri, John W. T. Walker et autres

Human papillomavirus (HPV)-associated cancer continues to evade the immune system by promoting a suppressive tumor microenvironment. Therefore, immunotherapy appears to be a promising approach for targeting HPV-associated tumors. We hypothesized that valproic acid (VA) as an epigenetic agent combined with avelumab may …

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Author response for "Transcriptomic profiling of peripheral blood cells in HPV-associated carcinoma patients receiving combined valproic acid and avelumab"

Najmeh Bozorgmehr, Hussain Syed, Siavash Mashhouri, John W. T. Walker et autres

Equity, Diversity and Inclusion in Canadian immunology: communication and complexity

Siavash Mashhouri, Sabryna Nantel, Saki Sultana, Dominique M. Gatti et autres

The Canadian Society for Immunology (CSI) organized an Equity, Diversity and Inclusion (EDI) training workshop during its 2022 Scientific Meeting to improve understanding of EDI and explore strategies to achieve EDI goals in the scientific environment. The workshop focused on identifying Specific, …

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CD71+ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors

Najmeh Bozorgmehr, Isobel Okoye, Siavash Mashhouri, Julia Lu et autres

Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. However, only a portion of patients respond to such treatments. Therefore, it remains a prevailing clinical need to identify factors associated with acquired resistance or lack of response to ICIs. We …

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Gout presenting as a chronic inflammatory arthritis from immune checkpoint inhibitors: case series

Kevin Lee, Shokrollah Elahi, Siavash Mashhouri, Carrie Ye

Dear Editor, as a consequence of immune checkpoint blockade, there is the risk of eliciting undue hyperimmune activation or autoimmune responses. The safety of immune checkpoint inhibitors (ICIs) has been of concern and several toxic episodes termed immune-related adverse events (irAEs) have …

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The Quality of SARS-CoV-2–Specific T Cell Functions Differs in Patients with Mild/Moderate versus Severe Disease, and T Cells Expressing Coinhibitory Receptors Are Highly Activated

Shima Shahbaz, Lai Xu, Wendy Sligl, Mohammed S. Osman et autres

Abstract Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for the monitoring of antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is described in COVID-19 patients. In this study, we explored and compared the effector …

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Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females

Siavash Mashhouri, Petya T. Koleva, Mai Huynh, Isobel Okoye et autres

Mature erythrocytes are the major metabolic regulators by transporting oxygen throughout the body. However, their precursors and progenitors defined as CD71+ Erythroid Cells (CECs) exhibit a wide range of immunomodulatory properties. Here, we uncover pronounced sexual dimorphism in CECs. We found female …

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Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

Najmeh Bozorgmehr, Siavash Mashhouri, Eliana Perez Rosero, Lai Xu et autres

Our results propose Gal-9 as an important contributing factor in cytokine release syndrome; therefore, Gal-9 inhibition may serve as a beneficial therapeutic approach by suppressing the hyperimmune activation in COVID-19 patients.

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