Isobel Okoye

Upper Airway Alarmin Cytokine Expression in Asthma of Different Severities

Hazel Marriott, Marc Duchesne, Subhabrata Moitra, Isobel Okoye et autres

Background: The secretion of alarmin cytokines by epithelial cells, including thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, initiates inflammatory cascades in asthma. However, alarmin cytokine expression in the upper airways in asthma remains largely unknown. Methods: We recruited 40 participants with …

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Upper Airway Alarmin Cytokine Expression in Asthma of Different Severities

Hazel Marriott, Marc Duchesne, Subhabrata Moitra, Isobel Okoye et autres

Background: The secretion of alarmin cytokines by epithelial cells, including thymic stromal lymphopoietin (TSLP), interleukin (IL)-25, and IL-33, heralds the onset of the inflammatory cascade and immune effector infiltration in asthma. However, alarmin cytokine expression in the upper airways in asthma remains …

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CD71+ erythroid cells suppress T-cell effector functions and predict immunotherapy outcomes in patients with virus-associated solid tumors

Najmeh Bozorgmehr, Isobel Okoye, Siavash Mashhouri, Julia Lu et autres

Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer. However, only a portion of patients respond to such treatments. Therefore, it remains a prevailing clinical need to identify factors associated with acquired resistance or lack of response to ICIs. We …

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Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response

Marc Duchesne, Isobel Okoye, Paige Lacy

The exposure of the airway epithelium to external stimuli such as allergens, microbes, and air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal lymphopoietin (TSLP). IL-25, IL-33 and TSLP interact with their ligands, IL-17RA, IL1RL1 and TSLPR …

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Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8+ T cells of HIV-infected individuals

Shima Shahbaz, Isobel Okoye, Gregg Blevins, Shokrollah Elahi

CD8+ T cells play a crucial role against chronic viral infections, however, their effector functions are influenced by the expression of co-stimulatory/inhibitory receptors. For example, CD73 works with CD39 to convert highly inflammatory ATP to adenosine. However, its expression on T cells …

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Sex Matters: Physiological Abundance of Immuno-Regulatory CD71+ Erythroid Cells Impair Immunity in Females

Siavash Mashhouri, Petya T. Koleva, Mai Huynh, Isobel Okoye et autres

Mature erythrocytes are the major metabolic regulators by transporting oxygen throughout the body. However, their precursors and progenitors defined as CD71+ Erythroid Cells (CECs) exhibit a wide range of immunomodulatory properties. Here, we uncover pronounced sexual dimorphism in CECs. We found female …

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Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4+ T Cells and Promote the Activation of Latently Infected J-Lat10.6 Cells via miR-139-5p Transfer

Isobel Okoye, Lai Xu, Olaide Oyegbami, Shima Shahbaz et autres

HIV latency is a challenge to the success of antiretroviral therapy (ART). Hence patients may benefit from interventions that efficiently reactivate the latent virus to be eliminated by ARTs. Here we show that plasma extracellular vesicles (pEVs) can enhance HIV infection of …

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Expanded antigen-experienced CD160+CD8+effector T cells exhibit impaired effector functions in chronic lymphocytic leukemia

Najmeh Bozorgmehr, Isobel Okoye, Olaide Oyegbami, Lai Xu et autres

BACKGROUND: T cell exhaustion compromises antitumor immunity, and a sustained elevation of co-inhibitory receptors is a hallmark of T cell exhaustion in solid tumors. Similarly, upregulation of co-inhibitory receptors has been reported in T cells in hematological cancers such as chronic lymphocytic …

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Tackling Immune Targets for Breast Cancer: Beyond PD-1/PD-L1 Axis

Yasser Tabana, Isobel Okoye, Arno G. Siraki, Shokrollah Elahi et autres

The burden of breast cancer is imposing a huge global problem. Drug discovery research and novel approaches to treat breast cancer have been carried out extensively over the last decades. Although immune checkpoint inhibitors are showing promising preclinical and clinical results in …

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Tackling Immune Targets for Breast Cancer Beyond PD-1PD-L1 Axis

Yasser Tabana, Isobel Okoye, Arno G. Siraki, Shokrollah Elahi et autres

The burden of breast cancer is imposing a huge global problem.Drug discovery research and novel approaches to treat breast cancer have been carried out extensively over the last decades.Although immune checkpoint inhibitors are showing promising preclinical and clinical results in treating breast …

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Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors

Isobel Okoye, Lai Xu, Melika Motamedi, Pallavi Parashar et autres

BACKGROUND: T cells in HIV patients was associated with impaired T cell effector functions. Gal-9 is a ligand for T cell immunoglobulin and mucin domain-3, and its expression on T cells in cancer has not been investigated. Therefore, we aimed to investigate …

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miR-182 and miR-10a Are Key Regulators of Treg Specialisation and Stability during Schistosome and Leishmania-associated Inflammation

Eleni Kistasis, Mark S. Wilson, Craig Martens, Dan E. Sturdevant et autres

A diverse suite of effector immune responses provide protection against various pathogens. However, the array of effector responses must be immunologically regulated to limit pathogen- and immune-associated damage. CD4+Foxp3+ regulatory T cells (Treg) calibrate immune responses; however, how Treg cells adapt to …