Flávia Almada do Carmo

Finasteride-loaded poly(lactic-co-glycolic acid) Nanoparticles Enhance Efficacy in Hair Regrowth: Preparation, Characterization, and In Vivo Study

Lara Soares Junqueira, Priscila de Souza Furtado, Daniel Figueiredo Vanzan, Gil Mendes Viana et autres

Advances in Formulation and Technological Strategies for Montelukast Pulmonary Delivery

Carla Giordani Testa, Millena de Sousa Afonso, João Vitor Vicente Da Silva, Érika Yoko Suzuki et autres

Montelukast is a leukotriene receptor antagonist used in the management of asthma by modulating airway inflammation. Conventional oral formulations exhibit considerable variation in bioavailability due to extensive first-pass metabolism, short half-life, and wide distribution into peripheral compartments. These limitations, along with systemic …

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In vitro–in vivo correlation for consolidation of permeation parameters using different membranes in Franz Cell with a transdermal rivastigmine patch

Viviane Osny Ribeiro, Giovanna Cersósimo Nader Mota, LARISSA SANTOS MOREIRA, André Luis de Alcantara Guimarães et autres

The permeation and release of transdermal drug delivery systems can be evaluated through in vitro Franz Cells performance assays. These can use different types of synthetic and natural membranes to make bioavailability predictions of transdermal formulations using in vitro – in vivo …

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Advances in Transdermal Drug Delivery Systems for Antithrombotic Therapy: A Systematic Review

Maria Augusta D. Stersi, Giovanna C. Nader-Mota, Érika Yoko Suzuki, Lúcio Mendes Cabral et autres

Thrombotic diseases, classified as arterial or venous, remain one of the most important global health concerns. Myocardial infarction, ischemic stroke, and venous thromboembolism (VTE), which include deep vein thrombosis and pulmonary embolism, are prominent causes of illness and death. Antithrombotic agents, classified …

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In Vivo Biostimulatory Efficacy of Ascorbic Acid-Loaded Poly(lactic-co-glycolic Acid) Nanoparticles Hydrogel for Dermal Remodeling

Anna Raphaella Autran Colaço, Priscila de Souza Furtado, Daniel Figueiredo Vanzan, Nicole Serqueira da Silva et autres

High Resolution Image Download MS PowerPoint Slide Synthetic, biocompatible, and biodegradable polymers such as poly- l -lactic acid (PLLA) and polycaprolactone (PCL) are used in the form of microparticles (25–200 μm) dispersed in injectable hydrogels for collagen biostimulation through mechanical stimuli and …

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Skin and Wound Healing: Conventional Dosage versus Nanobased Emulsions Forms

João Vitor Vicente Da Silva, Juliana Oliveira da Silva Lopes Pereira, Flávia Almada do Carmo, Beatriz Ferreira de Carvalho Patricio

The skin plays a crucial role in the body's homeostasis through its thermoregulation functions, metabolic activity, and, mainly, its barrier function. Once this system has its homeostasis disturbed, through the promotion of tissue discontinuity, an injury happens and a restoration process starts. …

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Development of inhaled moxifloxacin-metformin formulation as an alternative for pulmonary tuberculosis treatment

Alexander M. Simon, S O Velloso-Junior, RicardoAlves Mesquita, Ana Paula Gregório Alves Fontão et autres

Resistant M. tuberculosis strains threaten pulmonary tuberculosis (P-TB) control since they limit drug options. Drug repositioning and new development strategies are urgently required to overcome resistance. Studies have already shown the beneficial role of the oral antidiabetic metformin as an anti-tuberculosis adjuvant …

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Formulations with Active Plant Molecules and Additional Therapies in Wound Healing

Thayane Aparecida Alves de Araujo, Fernanda Resende Locatelli, Raquel Elisa da Silva-López, Flávia Almada do Carmo

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Development of ocular delivery systems for macitentan and ex vivo study of intraocular permeation

Mariana da Silva Gonçalves, Lúcio Mendes Cabral, Valéria Pereira de Sousa, Flávia Almada do Carmo

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Evaluation of Silybin Nanoparticles against Liver Damage in Murine Schistosomiasis mansoni Infection

Daniel Figueiredo Vanzan, Ester Puna Goma, Fernanda Resende Locatelli, Thiago da Silva Honório et autres

Silybin (SIB) is a hepatoprotective drug known for its poor oral bioavailability, attributed to its classification as a class IV drug with significant metabolism during the first-pass effect. This study explored the potential of solid lipid nanoparticles with (SLN-SIB-U) or without (SLN-SIB) …

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Use of In silico Methodologies to Predict the Bioavailability of Oral Suspensions: A Regulatory Approach

Thiago da Silva Honório, Alice Simon, Raiane Monteiro Clacino Machado, Carlos Rangel Rodrigues et autres

Background: Oral suspensions are heterogeneous disperse systems, and the particle size distribution, crystalline form of the dispersed solid, and composition of the formulation can be listed as parameters that control the drug dissolution rate and its bioavailability. Objective: The aim of this …

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In vivo evaluation of time-dependent antithrombotic effect of rivaroxaban-loaded poly(lactic-co-glycolic acid)/sodium lauryl sulfate or didodecyl dimethylammonium bromide nanoparticles in Wistar rats

Priscila de Souza Furtado, Alana de Oliveira, Pryscila Rodrigues, Anna Rita Santiago de Paula Gonçalves et autres

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