Alice Simon

Advances in Formulation and Technological Strategies for Montelukast Pulmonary Delivery

Carla Giordani Testa, Millena de Sousa Afonso, João Vitor Vicente Da Silva, Érika Yoko Suzuki et autres

Montelukast is a leukotriene receptor antagonist used in the management of asthma by modulating airway inflammation. Conventional oral formulations exhibit considerable variation in bioavailability due to extensive first-pass metabolism, short half-life, and wide distribution into peripheral compartments. These limitations, along with systemic …

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Design, Synthesis, and Biological Evaluation of Novel Multitarget 7-Alcoxyamino-3-(1,2,3-triazole)-coumarins as Potent Acetylcholinesterase Inhibitors

Nathália Fonseca Nadur, Larissa A. Ferreira, Daiana P. Franco, Luciana Luiz de Azevedo et autres

Background: Multitarget-directed ligands (MTDLs), particularly those combining cholinesterase inhibition with additional mechanisms, are promising candidates for Alzheimer’s disease (AD) therapy. Based on our previous identification of a dual-active coumarin derivative, we designed a new series of 7-alkoxyamino-3-(1,2,3-triazole)-coumarins. Methods: These compounds were synthesized …

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In Vivo Biostimulatory Efficacy of Ascorbic Acid-Loaded Poly(lactic-co-glycolic Acid) Nanoparticles Hydrogel for Dermal Remodeling

Anna Raphaella Autran Colaço, Priscila de Souza Furtado, Daniel Figueiredo Vanzan, Nicole Serqueira da Silva et autres

High Resolution Image Download MS PowerPoint Slide Synthetic, biocompatible, and biodegradable polymers such as poly- l -lactic acid (PLLA) and polycaprolactone (PCL) are used in the form of microparticles (25–200 μm) dispersed in injectable hydrogels for collagen biostimulation through mechanical stimuli and …

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New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens

Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues et autres

OBJECTIVE: The objective of this work is to investigate different sunscreens and Viscogel group organoclays for the preparation of new intercalated sunscreens to improve the effectiveness and safety in photoprotection using new approach methodology (NAMs). METHODS: For this study, we examined Diethylamino …

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Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studies

Gleyton Leonel Silva Sousa, Nathália Fonseca Nadur, Larissa A. Ferreira, Thiago da Silva Honório et autres

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CARACTERIZAÇÃO DO PERFIL FARMACOLÓGICO E TOXICOLÓGICO DE NANOPARTÍCULAS DE RIVAROXABANA VISANDO O TRATAMENTO DE DISTÚRBIOS TROMBÓTICOS

A. H. Oliveira, Peter R. Rodrigues, Pedro Carvalho Furtado, Alice Simon et autres

As doenças cardiovasculares representam uma das principais causas de mortalidade em todo mundo e dentre elas, é possível destacar o tromboembolismo venoso. O tratamento deste quadro patológico é baseado principalmente na utilização de medicamentos anticoagulantes, como a Rivaroxabana (RXB). Tal fármaco pode …

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AVALIAÇÃO DO PERFIL ANTI-HEMOSTÁTICO E TOXICOLÓGICO DE DERIVADOS UREIA COMO ALTERNATIVAS TERAPÊUTICAS PARA DOENÇAS TROMBÓTICAS

Paulina Almeida Rodrigues, A. S. Oliveira, PS Furtado, Gil Mendes Viana et autres

Os distúrbios trombóticos arteriais, são uma das principais causas de morbidade e mortalidade no mundo e envolvem a perda do equilíbrio hemostático. O tratamento para estas doenças baseia-se na utilização de fármacos inibidores da agregação plaquetária, como o Ácido Acetilsalicílico (AAS). No …

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Evaluation of Silybin Nanoparticles against Liver Damage in Murine Schistosomiasis mansoni Infection

Daniel Figueiredo Vanzan, Ester Puna Goma, Fernanda Resende Locatelli, Thiago da Silva Honório et autres

Silybin (SIB) is a hepatoprotective drug known for its poor oral bioavailability, attributed to its classification as a class IV drug with significant metabolism during the first-pass effect. This study explored the potential of solid lipid nanoparticles with (SLN-SIB-U) or without (SLN-SIB) …

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N,N'-disubstituted Ureas as Novel Antiplatelet Agents: Synthesis, Pharmacological Evaluation and In Silico Studies

Priscila de Souza Furtado, Gil Mendes Viana, Alana Agnes Silva Camargo de Oliveira, Vitor Won‐Held Rabelo et autres

Introduction: Thrombotic disorders are among the leading causes of morbidity and mortality worldwide. Drugs used in the prevention and treatment of atherothrombosis have pharmacokinetic limitations and adverse effects such as hemorrhagic conditions, highlighting the importance of developing more effective antiplatelet agents. Methods: …

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Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors

Gleyton Leonel Silva Sousa, Thiago da Silva Honório, Priscila de Souza Furtado, Alice Simon et autres

Thiosemicarbazone-acridine hybrids are prominent inhibitors of topoisomerases II. This study reports the design, synthesis, and antiproliferative evaluation of eighteen new acridine–thiosemicarbazone derivatives as possible inhibitors of topoisomerase IIα. In general, compounds showed moderate to low cytotoxicity in the first screening performed on …

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Design, Synthesis and Biological Evaluation of New Thiosemicarbazone-Acridine Derivatives as Multi-Target-Directed Ligand (Mtdl) for Alzheimer's Disease

Gleyton Leonel Silva Sousa, Nathália Fonseca Nadur, Larissa A. Ferreira, Thiago da Silva Honório et autres

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Use of In silico Methodologies to Predict the Bioavailability of Oral Suspensions: A Regulatory Approach

Thiago da Silva Honório, Alice Simon, Raiane Monteiro Clacino Machado, Carlos Rangel Rodrigues et autres

Background: Oral suspensions are heterogeneous disperse systems, and the particle size distribution, crystalline form of the dispersed solid, and composition of the formulation can be listed as parameters that control the drug dissolution rate and its bioavailability. Objective: The aim of this …

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