Raquel Elisa da Silva-López

Inhibitory Activity of Bauhinia forficata Link against Leishmania

Aline Santana Figueredo, Patrícia Fernandes Ferreira, Lucilene A. Silva, Claúdia Quintino da Rocha et autres

Abstract Bauhinia forficata is a Brazilian medicinal plant, named “cow's paw”. Aqueous leaf, seed and stem extracts were prepared and their protein content, and protease inhibitor (PI) activities were assessed. The highest protein concentration was observed in aqueous stem (BF-CA) and tris …

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Formulations with Active Plant Molecules and Additional Therapies in Wound Healing

Thayane Aparecida Alves de Araujo, Fernanda Resende Locatelli, Raquel Elisa da Silva-López, Flávia Almada do Carmo

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Proteases terapêuticas de planta: aspectos químicos, aplicações e formulações farmacêuticas

Raquel Elisa da Silva-López, Patrícia Fernandes Ferreira

Proteases are enzymes that cleave peptide bonds in proteins and peptides. Are found in all living organisms and mediate many crucial functions. These enzymes have been used by man since antiquity for various purposes such as food processing and treatment of various …

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A Novel Trypsin Kunitz-Type Inhibitor from Cajanus cajan Leaves and Its Inhibitory Activity on New Cancer Serine Proteases and Its Effect on Tumor Cell Growth

Erika Maria Gomes Ferreira Teixeira, Dario Eluam Kalume, Patrícia Fernandes Ferreira, Thayane Aparecida Alves et autres

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CAJANUS CAJAN: UMA LEGUMINOSA RICA EM INIBIDORES DE PROTEASES COM PROPRIEDADES MEDICINAIS.

Raquel Elisa da Silva-López

As leguminosas, família botânica com maior número de espécies e uma das numerosas, são importantes fontes de proteínas na dieta da população mundial e utilizadas como plantas medicinais. Seus componentes do metabolismo secundário, principalmente os flavonoides, são conhecidos insumos ativos farmacêuticos. Os …

Antileishmanial effects of Crotalaria spectabilis Roth aqueous extracts on Leishmania amazonensis

Juliana da Silva Pacheco, Érika Maria Gomes Ferreira Teixeira, RAMON G. PASCHOAL, Eduardo Caio Torres-Santos et autres

Fifteen polar extracts from leaf, seed, pod, stem, flower and root of Crotalaria spectabilis were prepared using aqueous systems, based on the principles of green chemistry, and showed different protease inhibitor (PI) activities on trypsin, papain, pepsin and the extracellular L. amazonensis …

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(Cajanus cajan (L.) Millsp.) Fabaceae

Raquel Elisa da Silva-López, Erika Maria Gomes Ferreira Teixeira

As leguminosas do gênero Cajanus são principalmente conhecidas pela espécie Cajanus cajan, vulgarmente denominada de “feijão guandu” e pigeonpea, originária da Ásia foi levada para a África e as Américas. Ela é cultivada em todas as regiões tropicais e semi-tropicais do mundo …

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Study of protease activity from Aspergillus awamori INCQS2B.361U2/1 extracellular fraction and modification of culture medium composition to isolate a novel aspartic protease

Raquel Elisa da Silva-López, Thayane Aparecida Alves de Araujo, Hélvio José Jalles Monteiro, Érika Maria Gomes Ferreira Teixeira et autres

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Plant Therapeutic Proteases: Chemical Aspects, Applications and Pharmaceutical Formulations

Patrícia Fernandes Ferreira, Raquel Elisa da Silva-López

Background: Plants are important sources of therapeutic proteases with expressive activity, stability, specificity, and efficiency. These proteases are employed at low concentrations and produce lesser side effects. They have complex tridimensional structures whose maintenance is a challenge, requiring specific conditions to guarantee …

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Cajanus Cajan (l.) Millsp Aqueous Extracts against Melanoma Cell Line and their Proteases

Erika Maria Gomes Ferreira Teixeira, Raquel Elisa da Silva-López, B. R. A. Da Silva, Ana Paula Gregório Alves Fontão et autres

Aims: Extract proteins with protease inhibitor (PI) activity from fresh organs of Cajanus cajan, using aqueous systems; study the activity of melanoma secreted proteases; investigate inhibitory effect of C. cajan extracts on melanoma proteases; and evaluated the effect of the extract, with …

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The main protease of SARS-CoV-2 as therapeutic target to development specific drugs to treat COVID-19

Raquel Elisa da Silva-López

The pandemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) denominated COVID-19 is an important problem of world public health because do not have specific drugs and vaccines available to control the disease progression and the rapid virusspreading. SARS-CoV-2 genome …

Plant protease inhibitors as specific strategies against cancer cells

Erika Maria Gomes Ferreira Teixeira, Danilo Oliveira, Raquel Elisa da Silva-López

Cancer is a disease that cause important mortality in the world and investigations in order to understand the mechanisms of tumor development and new treatments are crucial and are carried out in many laboratories worldwide. One of the mechanism of growth and …

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