Ken Takasone

Pyrophosphate Scintigraphy Changes After Tafamidis Therapy ― Proposed Novel Index From Quantitative Single-Photon Emission Computed Tomography ―

Tsuneaki Yoshinaga, Shin Yanagisawa, Masatoshi Minamisawa, Ken Takasone et autres

BACKGROUND: Because a disease-modifying therapy is now available, bone scintigraphy plays a crucial role in diagnosing transthyretin cardiac amyloidosis (ATTR-CM). METHODS AND RESULTS: We retrospectively analyzed 24 patients with ATTR-CM to determine the amyloid accumulation volume (AAV: mean standardized uptake value×volume) of …

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A 57-year-old male case of high temperature requirement A serine peptidase 1 (HTRA1)-related cerebral small vessel disease with “Chocolate Chip Sign” on susceptibility-weighted imaging

Ken Takasone, Katsuya Nakamura, Satoru Shinriki, Mitsuharu Ueda et autres

We report herein a 57-year-old man who presented with recurrent cerebral infarctions in one year. His father had multiple stroke episodes starting in his late 50s. Brain MRI FLAIR showed diffuse hyperintensities in the deep white matter, suggesting cerebral small vessel disease …

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Post-acute Corticospinal and Spinal Tractopathy after Coronavirus Disease 2019: A Novel Post-infectious Neurological Syndrome?

Nobuhiko Ohashi, Naoya Miyahara, Ko-ichi Tazawa, Ken Takasone et autres

We herein report two cases of tractopathy affecting the bilateral corticospinal tracts (CSTs) and the spinal cord following coronavirus disease 2019. Both patients developed progressive sensorimotor deficits with spasticity, a truncal sensory level with severely impaired deep sensation, and bowel/bladder dysfunction one …

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A Case of Minimally Symptomatic CADASIL Diagnosed on a White Matter Lesion Involving the External Capsule and Family History

Miho Kurashina, Akira Matsushima, Nobuhiko Ohashi, Ken Takasone et autres

55歳，男性．難聴の精査目的に施行した頭部MRIで偶発的に外包を含む左右対称性の白質病変を指摘された．臨床症状は軽微であったが，病変の分布と家族歴からCADASILが疑われた．NOTCH3遺伝子に既知の変異（p.R75P）を認め診断が確定した．変異のタイプによっては，一定の年齢に達しても古典的なCADASILの臨床像が認められないため，臨床症状に乏しくとも外包を含む特徴的な病変を認めた場合にCADASILを念頭に置く必要がある．

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Five-Year Results With Patisiran for Hereditary Transthyretin Amyloidosis With Polyneuropathy

David H Adams, Jonas Wixner, Michael J. Polydefkis, John L. Berk et autres

Importance: There is a lack of long-term efficacy and safety data on hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) and on RNA interference (RNAi) therapeutics in general. This study presents the longest-term data to date on patisiran for hATTR-PN. Objective: To present the …

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A case of POEMS syndrome presenting craniocervical vascular stenosis

Gaku Okumura, Ken Takasone, Nagaaki Katoh, Yoshiki Sekijima

A 54-years-old Japanese man visited local hospital with six-month history of progressive numbness and muscle weakness in his lower limbs. He was diagnosed with POEMS syndrome based on positive serum M-protein, elevated serum VEGF, and splenomegaly. MRI showed multiple cerebral infarcts in …

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Neurofilament light chain as a biomarker for hereditary ATTR amyloidosis − correlation between neurofilament light chain and nerve conduction study

Masateru Tajiri, Mitsuto Sato, Minori Kodaira, Akira Matsushima et autres

BACKGROUND: Neurofilament light chain (NfL) is a biomarker of neuronal injury in hereditary ATTR (ATTRv) amyloidosis. However, the correlation between NfL and nerve conduction study (NCS), the standard test for ATTRv neuropathy, has not been investigated. OBJECTIVE: Elucidate the correlation between NfL …

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Reduction of amyloid deposition by patisiran －Evaluation by gastroduodenal biopsy and amyloid 11C-Pittsburgh compound B PET PC117 (#228)

Shinji Masuko, Ken Takasone, Mitsuto Sato, Yusuke Mochizuki et autres

Neurofilament light chain as a biomarker for hereditary ATTR amyloidosis - Correlation between neurofilament light chain and nerve conduction study - PB27 (#138)

Masateru Tajiri, Mitsuto Sato, Minori Kodaira, Akira Matsushima et autres

Treatment outcome of DCyBorD therapy on patients with advanced systemic AL amyloidosis PA139 (#66)

Nagaaki Katoh, Ken Takasone, Akira Matsushima, Yoshiki Sekijima

Response to: Before SARS-CoV-2-related Encephalitis Can Be Attributed to Anti-GFAP Antibodies, Alternative Etiologies Must Be Ruled out

Masateru Tajiri, Ken Takasone, Minori Kodaira, Akio Kimura et autres

We were pleased to receive a letter from Finsterer concerning our paper (1) and have responded to his concerns.As Finsterer pointed out, the SARS-CoV-2 antigen test does not have high sensitivity in asymptomatic cases but has high specificity.Since our patient had symptoms …

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Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Following SARS-CoV-2 Infection

Masateru Tajiri, Ken Takasone, Minori Kodaira, Akio Kimura et autres

We herein report the first case of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy after coronavirus disease 2019 (COVID-19). A 23-year-old man experienced fatigue, a fever, and headache 14 days after the resolution of COVID-19. He was severely disoriented and admitted to …

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