Gaku Okumura

Factors associated with de novo overactive bladder following robot-assisted radical prostatectomy: impact of membranous urethral length and prostate volume

Madoka Kataoka, Yasukazu Nakanishi, Gaku Okumura, Erika Ikezoe et autres

Abstract Objective This study assessed the occurrence of de novo overactive bladder (OAB) and identified factors of de novo OAB after robot-assisted radical prostatectomy (RARP). Methods A total of 227 patients who underwent RARP and had no preoperative diagnosis of OAB were …

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Treatment Selection and Survival In Muscle‐Invasive Bladder Cancer: Real‐World Data on the Impact of Geriatric‐8 Screening

Gaku Okumura, Shugo Yajima, Erika Ikezoe, Shu Gozu et autres

AIM: Standard treatment for muscle-invasive bladder cancer (MIBC) includes radical cystectomy (RC), a highly invasive procedure. We evaluated the utility of the Geriatric-8 (G8) screening tool in guiding treatment and whether the survival benefit of RC differs by G8 score. METHODS: We …

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Time-varying prognostic value of circulating tumor DNA in urothelial carcinoma: A systematic review and reconstructed patient-data meta-analysis

Shugo Yajima, Gaku Okumura, Soichiro Yoshida, Wei Chen et autres

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A Bayesian reanalysis of the THOR trial cohort 1 using reconstructed individual patient data: interval-specific effects and clinically interpretable estimands under non-proportional hazards

Gaku Okumura, Soichiro Yoshida, Kohei Hirose, Shugo Yajima et autres

BACKGROUND: The phase 3 THOR trial (cohort 1) showed improved overall survival (OS) and progression-free survival (PFS) with erdafitinib versus chemotherapy in FGFR2/3-altered advanced urothelial carcinoma after prior programmed cell death protein 1 (PD-1) / programmed death-ligand 1 (PD-L1) inhibitor therapy. When …

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A Case of Bladder Paraganglioma With Negative Photodynamic Diagnosis Completely Resected by Staged En Bloc Transurethral Resection

Shu Gozu, Yasukazu Nakanishi, Gaku Okumura, Erika Ikezoe et autres

Introduction: Bladder paraganglioma can be challenging to distinguish from nonpapillary bladder cancer. Here, we report a case of nonfunctional bladder paraganglioma treated with photodynamic diagnosis-assisted en bloc transurethral resection of the bladder tumor. Case Presentation: A 78-year-old man was incidentally diagnosed with …

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Bayesian reanalysis of the PROfound trial: Olaparib in Asian patients with metastatic castration-resistant prostate cancer

Gaku Okumura, Soichiro Yoshida, Kohei Hirose, Shugo Yajima et autres

Objective The PROfound trial investigated the efficacy of the poly(adenosine diphosphate–ribose) polymerase inhibitor olaparib in metastatic castration-resistant prostate cancer with homologous recombination repair gene alterations, particularly in Cohort A ( BRCA1/2 or ATM alterations). However, the Asian subgroup analysis of Cohort A …

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Radical Nephroureterectomy in the Very Elderly: A Single-Center Experience of Patients Aged ≥85 Years

Shu Gozu, Shugo Yajima, Gaku Okumura, Erika Ikezoe et autres

OBJECTIVE: The incidence of upper tract urothelial carcinoma is increasing with population aging, yet evidence regarding radical nephroureterectomy (RNU) in very elderly patients is limited. This study evaluated perioperative outcomes, complications, and oncological results of RNU in patients aged ≥85 years compared …

IP36-14 RE-EVALUATING TREATMENTS FOR ADVANCED UROTHELIAL CARCINOMA USING RESTRICTED MEAN SURVIVAL TIME: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS

Shugo Yajima, Soichiro Yoshida, Wei Chen, Gaku Okumura et autres

IP36-12 BAYESIAN RE-ANALYSIS OF THE NIAGARA TRIAL USING RECONSTRUCTED INDIVIDUAL PATIENT DATA: EARLY EVENT‑FREE SURVIVAL GAINS WITH PERIOPERATIVE DURVALUMAB IN MUSCLE‑INVASIVE BLADDER CANCER

Kohei Hirose, Soichiro Yoshida, Shugo Yajima, Gaku Okumura et autres

IP38-30 BAYESIAN REANALYSIS OF OLAPARIB EFFICACY IN THE ASIAN SUBGROUP OF THE PROFOUND TRIAL

Gaku Okumura, Soichiro Yoshida, Kohei Hirose, Shugo Yajima et autres

Usefulness of Information and Communication Technology‐Based Patient Information Sharing System in Supporting Patients With Intractable Neurological Diseases

Yui Kamijo, Akiyo Hineno, Gaku Okumura, Yoshiki Sekijima et autres

ABSTRACT Background Multidisciplinary collaboration is crucial for patients with incurable neurological diseases. However, sharing information among medical staff across institutions is challenging. Our cloud‐based patient information sharing system uses information and communication technology to facilitate the sharing of patient information among professionals, …

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Impact of Preoperative Diagnosis of Overactive Bladder and Intravesical Prostatic Protrusion on Postoperative Overactive Bladder Symptom Improvement Following Robot‐Assisted Radical Prostatectomy

Yasukazu Nakanishi, Gaku Okumura, Erika Ikezoe, Shu Gozu et autres

OBJECTIVE: To assess whether postoperative improvement in overactive bladder (OAB) symptoms following robot-assisted radical prostatectomy (RARP) can be predicted by preoperative diagnosis of OAB and intravesical prostatic protrusion (IPP). METHODS: This retrospective study included 210 patients who underwent RARP between January 2022 …

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