Susanne Bremer‐Hoffmann

Implementation Plan for the proposed Qualification System for New Approach Methodologies (NAMs) in the food and feed sector with focus on nanomaterial risk assessment

Andrea Haase, Shirin M. Usmani, Alessia Bogni, Cecilia Bossa et autres

Abstract Many promising New Approach Methodologies (NAMs) emerged in the last decades but only some are taken up as OECD Test Guidelines (TGs). For regulatory decision‐making data from non‐guideline studies is primarily considered as mechanistic support rather than direct evidence. The nanotechnology …

de, Afrique du Sud, it, fr, be, nl, lu, sg (code pays fourni par la source)

P30-04 Proposal for a qualification system for New Approach Methodologies (NAMs) in the food and feed sector

Sara Usmani, Andrea Haase, José G. Barroso, Alessia Bogni et autres

de, it, fr, be, nl, lu (code pays fourni par la source)

Proposal for a qualification system for New Approach Methodologies (NAMSs) in the food and feed sector

Shirin M. Usmani, Andrea PD Dr. Haase, Joao Barroso, J. Bogni et autres

An Adverse Outcome Pathway for food nanomaterial-induced intestinal barrier disruption

D. Stanco, Dorelia Lipsa, Alessia Bogni, Susanne Bremer‐Hoffmann et autres

Introduction The ingestion of nanomaterials (NMs) may impair the intestinal barrier, but the underlying mechanisms remain evasive, and evidence has not been systematically gathered or produced. A mechanistic-based approach would be instrumental in assessing whether relevant NMs disrupt the intestinal barrier, thereby …

it (code pays fourni par la source)

An Adverse Outcome Pathway for Food Nanomaterial-induced Intestinal Barrier Disruption

D. Stanco, Dorelia Lipsa, Alessia Bogni, Susanne Bremer‐Hoffmann et autres

Abstract Introduction Ingestion of nanomaterials (NMs) might impair intestinal barrier, but the underlying mechanisms remain evasive, and evidence is not systematically gathered or produced. A mechanistic-based approach would be instrumental to assess if relevant NMs disrupt intestinal barrier to support NM risk …

be (code pays fourni par la source)

NAM-based hazard assessment of nanocellulose oral exposure: the NANOCELLUP project.

Francesco Cubadda, Stéphanie Blanquet-Diot, Susanne Bremer‐Hoffmann, Lucie Etienne-Mesmin et autres

International audience

OS01-04 Review of New Approach Methodologies for application in risk assessment of nanoparticles in the food and feed sector: status and challenges

Sara Usmani, Susanne Bremer‐Hoffmann, Karlien Cheyns, Francesco Cubadda et autres

de, it, be, fr, lu, nl (code pays fourni par la source)

Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges

Shirin M. Usmani, Susanne Bremer‐Hoffmann, Karlien Cheyns, Francesco Cubadda et autres

Abstract New Approach Methodologies (NAMs), broadly understood to include in silico, in chemico, in vitro and ex vivo methods, show great potential in advancing risk assessment albeit their regulatory implementation is lagging. The EFSA Guidance on risk assessment of nanomaterials (EFSA Guidance …

de, it, be, fr, lu, nl, sg (code pays fourni par la source)

Proposal for a qualification system for New Approach Methodologies (NAMs) in the food and feed sector: example of implementation for nanomaterial risk assessment

Andrea Haase, José G. Barroso, Alessia Bogni, Susanne Bremer‐Hoffmann et autres

Abstract Plenty of new approach methodologies (NAMs) for risk assessment have been developed but only some are included in OECD Test Guidelines (TGs) for regulatory implementation. Nevertheless, NAMs are increasingly applied, e.g. for nanomaterial (NM) risk assessments. The EFSA Guidance on NM …

de, it, fr, lu, be, nl (code pays fourni par la source)

Fostering scientific integrity and research ethics in a science-for-policy research organisation

Göran Lövestam, Susanne Bremer‐Hoffmann, Koen Jonkers, Pieter van Nes

The Joint Research Centre (JRC) is the European Commission’s in-house science and knowledge service, employing a substantial staff of scientists devoted to conducting research to provide independent scientific advice for EU policy. Focussed on various research areas aligned with EU priorities, the …

be (code pays fourni par la source)

Raw data of the EFSA NAMs Project on Nanofibres Lot 1 (Annex T) (GP/EFSA/SCER/2020/04) (Vincentini et al., 2023)

Olimpia Vincentini, Anne‐Louise Blier, Alessia Bogni, Morgane Brun et autres

Raw data of the in vitro experiments produced in the context of the 'EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects' outsourced …

it, fr, be (code pays fourni par la source)

EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects

Olimpia Vincentini, Anne‐Louise Blier, Alessia Bogni, Morgane Brun et autres

Nanocellulose (NC) is an emerging material in the food sector with several prospective application areas. Three main types of NC exist, i.e. bacterial NC (BNC), nanofibrillated cellulose (NFC), and cellulose nanocrystals (CNC). The biological sources and processing conditions affect several physicochemical parameters …

it, fr, be (code pays fourni par la source)