Lars Peter Lunding

Local Delivery of a Bio‐Engineered IL ‐37 Fc‐Fusion Ameliorates Experimental Allergic Asthma in Mice

Lars Peter Lunding, Marcel F. Nold, Claudia A. Nold‐Petry, Michael Wegmann

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Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Jonas Engelhardt, Kirsch Nc, Aileen Kerfin, Lars Peter Lunding et autres

The NLRP3 inflammasome is a multi-protein complex that plays a crucial role in inflammatory processes mediated by the innate immune system. Dysregulated NLRP3 activation has been implicated in age-related inflammatory diseases, making it a promising therapeutic target. Here, we report that the …

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C34-19 Enhanced Anti-inflammatory Effects of a Modified IL-37 Variant in Murine Models of Allergic Asthma

Lars Peter Lunding, Marcel F. Nold, C A Nold-Petry, Michael Wegmann

Abstract Rationale Interleukin-37 (IL-37) is an anti-inflammatory cytokine of the IL-1 family that suppresses innate and adaptive immune responses. Previous studies have shown that recombinant IL-37 attenuates airway inflammation in experimental asthma. However, its therapeutic efficacy remains limited by rapid degradation and …

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A beneficial environment promotes immune resilience through epigenetic regulation

Guilherme Dragunas, Markus Klotz, S Chen, Zeynep Ertüz et autres

Environmental factors are often detrimental; however, certain environments enhance immune resilience. Notably, children raised on traditional farms show reduced allergies and asthma prevalence. Here, we investigated how a beneficial environment, using farm dust (FD) extract, influenced lung immune function in ovalbumin-induced allergic …

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Distinct and context-dependent immunobiology of interleukin (IL)-36, IL-37, and IL-38: A comparative review

Farshad Niazpour, Lars Peter Lunding, Ina Rudloff, Marcel F. Nold et autres

Interleukin (IL)-36, IL-37, and IL-38 belong to the newer members of the IL-1 cytokine family that exert diverse and context-dependent immune functions. IL-36α/β/γ are predominantly pro-inflammatory cytokines, whereas IL-37 and IL-38 function mainly as anti-inflammatory mediators with distinct regulatory properties. Despite growing …

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Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

Lars Peter Lunding, Markus Weckmann, Ulrich M. Zissler, Constanze A. Jakwerth et autres

QUESTION: Epidemiological studies suggest that respiratory viral infections are major triggers of asthma exacerbations, and clinical studies have suggested the involvement of an increased interleukin-6 (IL-6) release. What is the pathophysiological role of IL-6 in asthma exacerbation, and which mechanisms lead to …

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Late Breaking Abstract - Immune Training of the IL6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

Lars Peter Lunding, Markus Weckmann, Ulrich M. Zissler, Constanze A. Jakwerth et autres

Question: Epidemiological studies suggest viral infections as major triggers of asthma exacerbations and an involvement of increased IL-6 release. What is the role of IL-6 in asthma exacerbation and which mechanisms lead to enhanced IL-6 release? Methods: Exacerbations of allergic asthma in …

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Correction: Identification of AAV variants with improved transduction of human vascular endothelial cells by screening AAV capsid libraries in non-human primates

Maria Stamataki, Julia Lüschow, Christina Schlumbohm, Malik Alawi et autres

“Random AAV display peptide libraries at a dose of between 7.2 × 1011 genomic particles (gp)/ animal (=1.6 × 1012 gp/kg bodyweight) and 6 × 1012 gp/animal (=2.4 × 1013 gp/ kg bodyweight) were infused into the saphenous vein of adult male …

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Identification of AAV variants with improved transduction of human vascular endothelial cells by screening AAV capsid libraries in non-human primates

Maria Stamataki, Julia Lüschow, Christina Schlumbohm, Malik Alawi et autres

The development of targeted vector systems for gene therapy has made impressive progress during the last decade. Promising vector candidates were identified by screening large pools of adeno-associated virus (AAV) mutants in small animal models. However, it became apparent that targeted AAV …

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Phleum pratense pollen-derived di-galactosyldiacylglycerols promote pro-allergic responses in mice

Nestor González Roldán, Lars Peter Lunding, Yukari Fujimoto, Sylvia Düpow et autres

Introduction: Grass pollen triggers nearly 30% of bronchial allergic asthma cases. While most Q8 research focuses on pollen allergens, pollen lipids may also influence allergic reactions. Previous studies demonstrated that Timothy grass (TG, Phleum pratense) lipids, such as phytoprostanes, can activate immune …

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Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations

Lars Peter Lunding, Markus Weckmann, Ulrich M. Zissler, Constanze A. Jakwerth et autres

Question: Epidemiological studies suggest respiratory viral infections are major triggers of asthma exacerbations, and clinical studies have suggested the involvement of an increased interleukin-6 (IL-6) release. What is the pathophysiological role of IL-6 in asthma exacerbation, and which mechanisms lead to enhanced …

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An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation

Liqiong Jiang, Lars Peter Lunding, William S. Webber, Karsten Beckmann et autres

Introduction: Interleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MAS and COVID-19 severity and mortality, particularly in COVID-19patients with MAS. …

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