Sara Ragucci

European Alpine yak meat: Nutritional assessment and structural-functional characterization of myoglobin, with emphasis on the inhibitory effect of carnosine on the pseudoperoxidase activity

Sara Ragucci, Nicola Landi, Laura Alberico, Rosita Russo et autres

Yak meat is emerging as an alternative to beef in Europe due to its taste, texture, and nutritional balance. Here, we report the European Alpine yak meat nutritional profile and the characterization of yak myoglobin (Mb), the haemoprotein responsible for meat colour …

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A new trastuzumab-ageritin-based immunotoxin that specifically kills breast cancer cells

Angela Oliver, Nicola Landi, Emanuela Iaccarino, Sara Ragucci et autres

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Purification, Amino Acid Sequence, and Structural Features of a Novel Expansin-like A from the Seeds of Canihua (Chenopodium pallidicaule Aellen)

Sara Ragucci, Maria Giuseppina Campanile, Rosario Marín Iglesias, Nicola Landi et autres

Expansin-like A (EXLA) proteins belong to one of the four main families within the expansin superfamily, a group of plant proteins essential for cell wall loosening. Here, we report, for the first time, the purification of a novel EXLA, named cpEXLA, from …

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Proximate Composition, Amino Acid Content and Antioxidant Activity of Different Potato Varieties from the Matese Plateau (Southern Italy)

Nicola Landi, Sara Ragucci, Sofia Del Gaudio, Maria Giuseppina Campanile et autres

Here, the proximate composition, total amino acid content and antioxidant activity of Agria, Désirée and Kennebec potato varieties cultivated on the Matese plateau (Campania region, Southern Italy) were evaluated. Significant differences were observed among varieties in terms of proteins (1.98-3.07 g/100 g …

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Ribosome-Inactivating Proteins from Salsola soda L. and Saponaria officinalis L. Are Promising Candidates for Targeted Therapy of Colon Cancer

Francesco Biscotti, Sara Ragucci, Massimo Bortolotti, Federica Falà et autres

Background/Objectives: Ribosome-inactivating proteins (RIPs) are plant-derived enzymes with potent cytotoxic activity, widely studied as anticancer agents, particularly as toxic payloads in immunoconjugates. Despite numerous encouraging results reported, their clinical application has been limited by their immunogenicity. RIPs from edible plants have been …

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Edulitin 2, a Ribotoxin‐Like Protein From Boletus edulis That Triggers Apoptosis in Colon Cancer Cells While Preserving the Integrity of the Intestinal Microbiota

Massimo Bortolotti, Sara Ragucci, Federica Falà, Anella Saggese et autres

ABSTRACT Porcini ( Boletus edulis Bull.) are a reservoir of pharmacological biomolecules with health‐promoting properties. Here, we investigated the cytotoxic activity of edulitin 2, a ribotoxin‐like protein purified from B. edulis fruiting bodies, against two human colon cancer cell lines (Caco‐2 and …

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Thermal stability and enzymatic activity of quinoin, a type 1 ribosome inactivating protein (RIP) from quinoa seeds

Marco Campanile, Sara Ragucci, Ilaria Di Donato, Rosario Oliva et autres

Abstract Quinoin is a type 1 ribosome inactivating protein (RIP) isolated from Chenopodium quinoa seeds exhibiting enzymatic features, such as polynucleotide:adenosine glycosylase (PNAG) activity on DNA and a broad spectrum of biological functions, including antiviral, antifungal, and antitumour activities. In this study, …

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Chemical Traits and Microbial Population Characterization of ‘Asprinio’ Grape Must, a Local Vine Cultivated in Campania Region (Italy)

Nicola Landi, Monica Scognamiglio, Lidia Muscariello, Rosangela Marasco et autres

‘Asprinio’ grape is used to produce a white wine from the Campania region, known as ‘Asprinio’ (DOC since 1993). A plethora of approaches was adopted to characterize the organic compounds (e.g., free amino acids and other metabolites) and microbial population (bacteria and …

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Nutritional Values and Biochemical Traits of Rye (Secale cereale L.) Seeds, a Landrace from Matese Mountains (Southern Italy)

Nicola Landi, Sara Ragucci, Maria Giuseppina Campanile, Hafiza Z. F. Hussain et autres

Rye (Secale cereale L.) from Matese mountains is a local landrace cultivated in Southern Italy. To promote the benefits for the mountain economy, we report on the nutritional values (crude proteins, lipids, moisture, ash and total amino acids), metabolic traits (free amino …

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Hortensin 4, main type 1 ribosome inactivating protein from red mountain spinach seeds: Structural characterization and biological action

Sara Ragucci, Maria Giuseppina Campanile, Veronica Russo, Nicola Landi et autres

Here, we report the primary structure of hortensin 4, main type 1 ribosome inactivating protein (RIP) isolated from Atriplex hortensis seeds. The complete sequencing was achieved by a combination of mass spectrometry coupled with Edman degradation. The amino acid sequence of hortensin …

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Effects of indicitin, a novel ribosome-targeting enzyme from milky mushrooms, on four human cell lines and the gut microbiota

Nicola Landi, Massimo Bortolotti, Sara Ragucci, Ylenia De Luca et autres

M) by selectively cleaving the α-sarcin-ricin loop of 28S rRNA in animal ribosomes. In addition, the N-terminal amino acid sequence and structural features highlight that indicitin belongs to the thaumatin-like protein family. Indicitin exhibits a dose- and time-dependent cytotoxic activity against Raji …

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Melleatin, an antibiofilm multitasking protein with rRNA N-glycosylase and nuclease activity from Armillaria mellea fruiting bodies

Hafiza Z. F. Hussain, Sara Ragucci, Maria Teresa Gentile, Laura Alberico et autres

value 16.48 ± 3.71 nM); ii) damage rabbit and Trichoderma harzianum ribosomes as a ribosome inactivating protein (β-fragment release after Endo's assay); and iii) hydrolyse DNA. Functionally, melleatin has antibiofilm action and antifungal activity towards T. harzianum and Botrytis cinerea affecting fungal …

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