Maria Teresa Gentile

Additive effect of Ruta graveolens bioactive phytoconstituents and cisplatin through PKC/MEK/ERK pathway in glioblastoma

Grazia Romano, Valentina Morgera, Antonio Pezone, Samantha Messina et autres

-diamminedichloroplatinum (cisplatin, CDDP). Cytostatic responses were assessed by cell viability (TB exclusion test), cell cycle (propidium iodide [PI] staining), and apoptosis (Annex-V and caspase-3) assays. We demonstrate that RGWE slows U-87 MG growth without affecting apoptosis and arrests the cell cycle in …

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Gold Nanoparticles Enhance Radiosensitivity in Glioblastoma Cells

Laura Coppola, Giovanna Navarra, Giorgio Avilia, Carlos Cuestas-Ayllón et autres

BACKGROUND: Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor with a poor patient prognosis. Standard of care treatment includes maximal surgical resection, followed by radiotherapy and temozolomide administration. Despite this multimodal strategy, patients fail to achieve an effective response due …

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Positively Charged Polymers Based on Cyclodextrins for Trametinib and Selumetinib Delivery in Glioblastoma Cancer

Noemi Bognanni, Maria Teresa Gentile, Antonia Feola, Valentina Giglio et autres

Glioblastoma (GB) is the most common and aggressive malignant brain tumor, with a median survival of only 12-15 months despite current treatments with surgery, radiotherapy, and temozolomide (TMZ). Although TMZ induces cytotoxic DNA methylation in tumor cells, its efficacy is often limited …

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Polystyrene and polytetrafluoroethylene nanoplastics affect probiotic bacterial characteristics and penetrate their cellular membrane

Eunice Wairimu Maina, Ida De Chiara, Gennaro Gentile, Concetta Auciello et autres

Nanoplastics of different surface chemistries induce strain-specific alterations in bacterial membrane integrity and viability, highlighting potential impacts on gut microbiota stability.

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In vitro antitumor activity of Lactococcus lactis cell-free supernatant on human glioblastoma cell lines

Ida De Chiara, Antonia Feola, Milena Della Gala, Rosangela Marasco et autres

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Antitumor activity of Lactococcus lactis cell-free supernatant on human glioblastoma cell lines

Ida De Chiara, Antonia Feola, Milena Della Gala, Rosangela Marasco et autres

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Polystyrene nanoparticles induce DNA damage and apoptosis in HeLa cells

Antonia Feola, Manoj Madheswaran, Grazia Romano, Awet Ghebretinsae Tewelde et autres

Nanoplastics (NPs) are plastic particles, typically less than 100 nm in size, that result from daily life products as well as the degradation of larger plastic debris. Due to their small size and chemical composition, they can interact with biological systems in …

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Melleatin, an antibiofilm multitasking protein with rRNA N-glycosylase and nuclease activity from Armillaria mellea fruiting bodies

Hafiza Z. F. Hussain, Sara Ragucci, Maria Teresa Gentile, Laura Alberico et autres

value 16.48 ± 3.71 nM); ii) damage rabbit and Trichoderma harzianum ribosomes as a ribosome inactivating protein (β-fragment release after Endo's assay); and iii) hydrolyse DNA. Functionally, melleatin has antibiofilm action and antifungal activity towards T. harzianum and Botrytis cinerea affecting fungal …

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Multiple aspects of matrix stiffness in cancer progression

Alessandro Mancini, Maria Teresa Gentile, Francesca Pentimalli, Salvatore Cortellino et autres

The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial in the processes of cell differentiation and proliferation. However, it is unclear to what extent tumor cells are influenced by biomechanical and biophysical changes of the surrounding microenvironment and how …

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Polystyrene Nanoparticles Induce DNA Damage and Apoptosis in HeLa Cells

Antonia Feola, Manoj Madheswaran, Grazia Romano, Awet Ghebretinsae Teweldebe et autres

Neuro-Nutraceutical Polyphenols: How Far Are We?

Maria Teresa Gentile, Iolanda Camerino, Loredana Filomena Ciarmiello, Pasqualina Woodrow et autres

The brain, composed of billions of neurons, is a complex network of interacting dynamical systems controlling all body functions. Neurons are the building blocks of the nervous system and their impairment of their functions could result in neurodegenerative disorders. Accumulating evidence shows …

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High-Resolution Conformational Analysis of RGDechi-Derived Peptides Based on a Combination of NMR Spectroscopy and MD Simulations

Clementina Acconcia, Antonella Paladino, Maria della Valle, Biancamaria Farina et autres

The crucial role of integrin in pathological processes such as tumor progression and metastasis formation has inspired intense efforts to design novel pharmaceutical agents modulating integrin functions in order to provide new tools for potential therapies. In the past decade, we have …

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