Accès ouvert
2026
article
OpenAlex
Sara Ragucci, Maria Giuseppina Campanile, Rosario Iglesias, Nicola Landi et autres
Expansin-like A (EXLA) proteins belong to one of the four main families within the expansin superfamily, a group of plant proteins essential for cell wall loosening. Here, we report, for the first time, the purification of a novel EXLA, named cpEXLA, from …
it, es, ar
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Accès ouvert
2026
article
OpenAlex
Mario Cazalla, Alejandro Parra, Carlos Rodríguez‐Antolín, Cristina Silván et autres
Beckwith-Wiedemann spectrum (BWSp) is an overgrowth disorder caused by both genetic and epigenetic defects within the 11p15.5 chromosomal region. The most common cause of BWSp is DNA methylation anomalies in two imprinting control regions (ICR1, the telomeric centre that includes H19/IGF2:IG-DMR and …
es, pt
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Accès ouvert
2024
article
OpenAlex
Rosario Iglesias, Lucı́a Citores, Carolina Gay, José M. Ferreras
The control of crop diseases caused by fungi remains a major problem and there is a need to find effective fungicides that are environmentally friendly. Plants are an excellent source for this purpose because they have developed defense mechanisms to cope with …
es, ar
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Accès ouvert
2024
article
OpenAlex
Lucı́a Citores, Sara Ragucci, Carolina Gay, Rosita Russo et autres
Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that irreversibly inhibit protein synthesis and consequently cause cell death. Recently, an RIP called ledodin has been found in shiitake; it is cytotoxic, strongly inhibits protein synthesis, and shows rRNA …
es, it, ar
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Accès ouvert
2023
article
OpenAlex
Sara Ragucci, Nicola Landi, Lucı́a Citores, Rosario Iglesias et autres
Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the sarcin–ricin loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk). This action blocks protein …
it, es
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Accès ouvert
2023
preprint
OpenAlex
Sara Ragucci, Nicola Landi, Lucı́a Citores, Rosario Iglesias et autres
Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the Sarcin-Ricin Loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk). This action blocks protein …
it, es
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Lucı́a Citores, Sara Ragucci, Rosita Russo, Claudia Carolina Gay et autres
We have purified ledodin, a cytotoxic 22-kDa protein from shiitake mushroom (Lentinula edodes) consisting of a 197 amino acid chain. Ledodin possessed N-glycosylase activity on the sarcin-ricin loop of mammalian 28S rRNA and inhibited protein synthesis. However, it was not active against …
es, it, ar
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Accès ouvert
2022
article
OpenAlex
Rosario Iglesias, Rosita Russo, Nicola Landi, Mariangela Valletta et autres
Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that catalyze the removal of a specific adenine located in the sarcin–ricin loop of the large ribosomal RNA, which leads to the irreversible inhibition of protein synthesis and, consequently, cell …
es, it
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Accès ouvert
2022
article
OpenAlex
Nicola Landi, Sara Ragucci, Lucı́a Citores, Angela Clemente et autres
Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate the major rRNA, damaging ribosomes and inhibiting protein synthesis. Here, new single-chain (type-1) RIPs named sodins were isolated from the seeds (five proteins), edible leaves (one protein) and roots (one protein) of …
it, es
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Accès ouvert
2022
article
OpenAlex
Marjan Manouchehri, Lucía Cea Soriano, Josep Franch‐Nadal, Antonio Ruíz et autres
Abstract Prediabetes and not just diabetes can cause kidney damage. This study assess the association of prediabetes with development of impaired renal function (IRF). We used data from PREDAPS prospective study a cohort of 1072 subjects with prediabetes and another cohort of …
es
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Accès ouvert
2022
article
OpenAlex
Lucı́a Citores, Mariangela Valletta, Vikram Singh, Paolo V. Pedone et autres
Penicillium digitatum is a widespread pathogen responsible for the postharvest decay of citrus, one of the most economically important crops worldwide. Currently, chemical fungicides are still the main strategy to control the green mould disease caused by the fungus. However, the increasing …
es, it
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Accès ouvert
2021
article
OpenAlex
Stefania Maiello, Rosario Iglesias, Letizia Polito, Lucı́a Citores et autres
Kirkiin is a new type 2 ribosome-inactivating protein (RIP) purified from the caudex of Adenia kirkii with a cytotoxicity compared to that of stenodactylin. The high toxicity of RIPs from Adenia genus plants makes them interesting tools for biotechnology and therapeutic applications, …
it, es
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