Zahra Nourian

Small Arteries From Old Spontaneously Hypertensive Rats Exhibit Enhanced Endothelium‐Independent Vasodilatory Capacity and Reduced Stiffness

Francisco I. Ramirez‐Perez, Thomas J. Jurrissen, Marc A. Augenreich, Jorge A. Castorena‐Gonzalez et autres

OBJECTIVE: In conduit arteries, aging and hypertension are associated with stiffening characterized by increased cytoskeletal F-actin and endothelial dysfunction. Herein, we determined if this also happens at the level of the resistance vasculature. METHODS: We retrospectively compared the mechanical and structural characteristics …

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Right ventricular preload and afterload challenge induces contractile dysfunction and arrhythmia in isolated hearts of dystrophin‐deficient male mice

Andrew Behrmann, Jessica Cayton, Matthew R. Hayden, Michelle D. Lambert et autres

Abstract Duchenne muscular dystrophy (DMD) is an X‐linked recessive myopathy due to mutations in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and elevated afterload on the right ventricle (RV). Thus, RV dysfunction in DMD develops early in disease progression. Herein, …

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Transient receptor potential vanilloid 4 and atrial arrhythmogenesis in aged mouse hearts

Jessica Cayton, Matthew R. Hayden, Michelle D. Lambert, Zahra Nourian et autres

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Combined Right Ventricular Preload and Afterload Challenge Induces Contractile Dysfunction and Ventricular Arrhythmia in an Age-dependent Manner in Isolated Hearts of Dystrophin-deficient Mice

Andrew Behrmann, Jessica Cayton, Matt Hayden, Michelle Lambert et autres

Abstract Duchenne muscular dystrophy (DMD) is an X-linked recessive myopathy due to mutations in the dystrophin gene. Diaphragmatic weakness in DMD causes restrictive lung disease and excessive afterload on the right ventricle (RV). Thus, RV dysfunction in DMD develops early in disease …

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Calcium handling dysfunction and cardiac damage following acute ventricular preload challenge in the dystrophin-deficient mouse heart

V Haffner, Zahra Nourian, Erika M. Boerman, Michelle D. Lambert et autres

The mechanisms of cardiac disease progression in muscular dystrophy are complex and poorly understood. Using a transgenic mouse model with cardiomyocyte-specific expression of the GCaMP6f Ca2+ indicator, the present study provides further support for the Ca2+-overload hypothesis of disease progression and ventricular …

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Atrial arrhythmogenesis in ex vivo aged mouse hearts with hypokalemia and right atrial stretch

Jessica Cayton, Zahra Nourian, Michelle Lambert, Zhenguo Liu et autres

Abstract Introduction Atrial Fibrillation (AF) and atrial flutter (AFL) are the two most common cardiac arrhythmias in the United States. While advanced age has been correlated to AF/AFL, the lack of an appropriate animal model has hindered progress on better understanding the …

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Postnatal development of extracellular matrix and vascular function in small arteries of the rat

Zahra Nourian, Kwangseok Hong, Min Li, Jorge A. Castorena‐Gonzalez et autres

Introduction: Vascular extracellular matrix (ECM) is dominated by elastic fibers (elastin with fibrillin-rich microfibrils) and collagens. Current understanding of ECM protein development largely comes from studies of conduit vessels (e.g., aorta) while resistance vessel data are sparse. With an emphasis on elastin, …

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Effect of hypokalemia and right atrial stretch on atrial arrhythmogenesis with aging

Jessica Cayton, Zahra Nourian, Michelle Lambert, Timothy L. Domeier

Atrial Fibrillation (AF) is the most common sustained arrhythmia, and more than 2.7 million people are living with AF in the United States. The elderly are at greatest risk for AF with prevalence estimated at ~10% in individuals over the age of …

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The potential role of matrix metalloproteinases on reducing small artery stiffness and improving vasodilation in old spontaneously hypertensive rats

Marc A. Augenreich, Thomas J. Jurrissen, Francisco I. Ramirez‐Perez, Jorge A. Castorena‐Gonzalez et autres

Arterial stiffening is a major risk factor for cardiovascular disease development and progression. Both hypertension and aging are associated with presence of microcirculation endothelial dysfunction, hypercontractility, and vascular stiffening. Reports suggest that while hypertension results in inward remodeling, aging is associated with …

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Right ventricular function in hearts of a mouse model of Duchenne muscular dystrophy following increased ventricular load

Michelle Lambert, Andrew Behrmann, Zahra Nourian, Keith Nyanyo et autres

Duchenne muscular dystrophy (DMD) is an X-linked recessive myopathy caused by mutations in the gene encoding dystrophin. Dystrophin is present in striated muscle cells and stabilizes the sarcolemma to mitigate contraction-induced damage. The main cause of death in DMD is cardiopulmonary failure …

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Modification of Fibronectin by Non-Enzymatic Glycation Impairs K+ Channel Function in Rat Cerebral Artery Smooth Muscle Cells

Yan Yang, Zahra Nourian, Min Li, Zhe Sun et autres

Fibronectin (FN) enhances K+ channel activity by integrin-mediated mechanisms. As vascular smooth muscle (VSM) K+ channels mediate vasodilation, we hypothesized that modification of fibronectin, via advanced non-enzymatic glycation, would alter signaling of this extracellular matrix protein through these channels. Bovine FN (1 …

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Ventricular Dysfunction and Calcium Handling Derangements in Isolated Hearts From Duchenne Muscular Dystrophy (DMD mdx‐4CV ) Mice Following Sustained Ventricular Preload

Vivian C. Onyali, Zahra Nourian, Laurin M. Hanft, Maike Krenz et autres

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and is caused by mutations in the dystrophin gene. Subclinical signs of cardiac disease present early and usually progress to dilated cardiomyopathy in late stage DMD patients. Dystrophin deficiency associates with stretch‐induced …

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