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Profil bibliographique

Heiko Giese

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

11Publications signalées
290Citations signalées
1Affiliations récentes

Les institutions déclarées

Les domaines associés

Mitochondrial Function and PathologyBioinformatics and Genomic NetworksMetabolomics and Mass Spectrometry StudiesGene Regulatory Network AnalysisATP Synthase and ATPases Research

Les publications récentes

Accès ouvert 2020 article OpenAlex

A salvage pathway maintains highly functional respiratory complex I

Karolina Szczepanowska, Katharina Senft, Juliana Heidler, Marija Herholz et autres

Regulation of the turnover of complex I (CI), the largest mitochondrial respiratory chain complex, remains enigmatic despite huge advancement in understanding its structure and the assembly. Here, we report that the NADH-oxidizing N-module of CI is turned over at a higher rate …

de, nl, us (code pays fourni par la source)

126 citations Nature Communications
Accès ouvert 2018 article OpenAlex

The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation

Simranjit X. Singh, Simon Lämmle, Heiko Giese, Susanne Kämmerer et autres

Abstract Heart failure is the most common cause of morbidity and hospitalization in the western civilization. Protein phosphatases play a key role in the basal cardiac contractility and in the responses to β-adrenergic stimulation with type-1 phosphatase (PP-1) being major contributor. We …

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14 citations Scientific Reports
2018 article OpenAlex

isiKnock: in silico knockouts in signaling pathways

Jennifer Hannig, Heiko Giese, Börje Schweizer, Leonie K. Amstein et autres

SUMMARY: isiKnock is a new software that automatically conducts in silico knockouts for mathematical models of signaling pathways. The software allows for the prediction of the behavior of biological systems after single or multiple knockout. The implemented algorithm applies transition invariants and …

de (code pays fourni par la source)

10 citations Bioinformatics
Accès ouvert 2018 preprint OpenAlex

isiKnock: in silico knockouts in biochemical pathways

Jennifer Scheidel, Heiko Giese, Börje Schweizer, Leonie K. Amstein et autres

Abstract Summary isiKnock is a new software that automatically conducts in silico knockouts for mathematical models of biochemical pathways. The software allows for the prediction of the behavior of biological systems after single or multiple knockout. The implemented algorithm applies transition invariants …

de (code pays fourni par la source)

0 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2015 preprint OpenAlex

Cluster analysis and visualization techniques for large datasets in complexome profiling

Heiko Giese, Jörg Ackermann, Ulrich Brandt, Ilka Wittig et autres

Dysfunctional protein complexes are often associated with diseases. To develop effective treatments it is essential to understand the composition, formation and functionality of protein complexes. Novel techniques like complexome profiling give an overview of possible protein-protein interactions in an entire sample. In …

de, nl (code pays fourni par la source)

1 citation
Accès ouvert 2015 preprint OpenAlex

Cluster analysis and visualization techniques for large datasets in complexome profiling

Heiko Giese, Jörg Ackermann, Ulrich Brandt, Ilka Wittig et autres

Dysfunctional protein complexes are often associated with diseases. To develop effective treatments it is essential to understand the composition, formation and functionality of protein complexes. Novel techniques like complexome profiling give an overview of possible protein-protein interactions in an entire sample. In …

de, nl (code pays fourni par la source)

0 citations
Accès ouvert 2014 article OpenAlex

NOVA: a software to analyze complexome profiling data

Heiko Giese, Jörg Ackermann, Heinrich Heide, Lea Bleier et autres

SUMMARY: We introduce nova, a software for the analysis of complexome profiling data. nova supports the investigation of the composition of complexes, cluster analysis of the experimental data, visual inspection and comparison of experiments and many other features. AVAILABILITY AND IMPLEMENTATION: nova …

de, nl (code pays fourni par la source)

90 citations Bioinformatics

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