Accès ouvert
2025
article
OpenAlex
Kevin A. Murach, Cory M. Dungan, Toby L. Chambers, Steve Horvath et autres
Adult resident stem cells are capable of regenerating tissues that manifest signs of "rejuvenation" in flatworms and mice of older ages. These findings suggest potentially conserved regulatory mechanisms of adult resident stem cells from worms to mammals. Regenerative capacities are more limited …
us
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Accès ouvert
2025
article
OpenAlex
Xiaoting Dai, Xinghua Li, Alexander Tyshkovskiy, Cassandra Zuckerman et autres
The possibility of reversing the adverse impacts of aging could significantly reduce age-related diseases and improve quality of life in older populations. Here we report that the sexual lineage of the planarian Schmidtea mediterranea exhibits physiological decline within 18 months of birth, …
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Accès ouvert
2025
article
OpenAlex
Blanka Rogina, Rozalyn M. Anderson, Nathan K. LeBrasseur, Sean Curan et autres
The aging process is universal, and it is characterized by a progressive deterioration and decrease in physiological function leading to decline on the organismal level. Nevertheless, a number of genetic and nongenetic interventions have been described, which successfully extend healthspan and lifespan …
us, ca, de, dk, gb, it
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Accès ouvert
2023
article
OpenAlex
Tatyana Y. Fedina, Easton T. Cummins, Daniel Promislow, Scott D. Pletcher
The motivation to reproduce is a potent natural drive, and the social behaviors that induce it can severely impact animal health and lifespan. Indeed, in Drosophila males, accelerated aging associated with reproduction arises not from the physical act of courtship or copulation …
us
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Accès ouvert
2023
conference-abstract
OpenAlex
Scott D. Pletcher
Abstract Humans, scientists especially, like to believe that we are in control of our behaviors and that logical, rational thought is the driving force behind them. Even for the most conscious of actions, however, there are serious questions about whether this is …
us
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Accès ouvert
2023
preprint
OpenAlex
Xiaoting Dai, Xinghua Li, Scott D. Pletcher, David Paris et autres
Abstract An ability to delay aging—or to reverse the negative effects of aging—could prevent age-related disease and greatly enhance quality of life in old age. However, whether it is possible to globally reverse the physiological effects of aging in order to extend …
us
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Accès ouvert
2023
article
OpenAlex
Kristina J Weaver, Sonakshi Raju, Rachel A Rucker, Tuhin Chakraborty et autres
Hunger is a motivational drive that promotes feeding, and it can be generated by the physiological need to consume nutrients as well as the hedonic properties of food. Brain circuits and mechanisms that regulate feeding have been described, but which of these …
us
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Accès ouvert
2023
peer-review
OpenAlex
Kristina J Weaver, Sonakshi Raju, Rachel A Rucker, Tuhin Chakraborty et autres
us
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Accès ouvert
2023
article
OpenAlex
Christi M. Gendron, Tuhin S. Chakraborty, C Mónica Duran, Thomas Dono et autres
Sensory perception modulates aging, yet we know little about how. An understanding of the neuronal mechanisms through which animals orchestrate biological responses to relevant sensory inputs would provide insight into the control systems that may be important for modulating lifespan. Here, we …
us
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Accès ouvert
2023
peer-review
OpenAlex
Keith A. Weaver, S Raju, R Rucker, Tanusree Chakraborty et autres
Hunger is a motivational drive that promotes feeding, and it can be generated by the physiological need to consume nutrients as well as the hedonic properties of food. Brain circuits and mechanisms that regulate feeding have been described, but which of these …
us
(code pays fourni par la source)
Accès ouvert
2023
peer-review
OpenAlex
Keith A. Weaver, S Raju, R Rucker, Tanusree Chakraborty et autres
Hunger is a motivational drive that promotes feeding, and it can be generated by the physiological need to consume nutrients as well as the hedonic properties of food. Brain circuits and mechanisms that regulate feeding have been described, but which of these …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Kristina J Weaver, Robert A. Holt, E Henry, Yang Lyu et autres
Hunger is an ancient drive, yet the molecular nature of pressures of this sort and how they modulate physiology are unknown. We find that hunger modulates aging in Drosophila . Limitation of branched-chain amino acids (BCAAs) or activation of hunger-promoting neurons induced …
us
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