Accès ouvert
2026
article
OpenAlex
Ligia-Maria Ceteraș, Vlad Dumitru Brata, Ioana Dobrotă, Rahela Borbei et autres
Cardiovascular-kidney-metabolic (CKM) syndrome encompasses the convergent pathophysiology of obesity, insulin resistance, type 2 diabetes, chronic kidney disease, and cardiovascular disease, conditions whose interactions account for a substantial proportion of cardiovascular morbidity and mortality despite contemporary guideline-directed therapy. Nitric oxide (NO) pathway dysfunction …
ro
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Accès ouvert
2026
article
OpenAlex
Rahela Borbei, Vlad Dumitru Brata, Ioana Dobrotă, Ligia-Maria Ceteraș et autres
Metabolic syndrome (MetS) is a composite classification defined by heterogeneous combinations of cardiometabolic abnormalities. Several components have been associated with pancreatic cancer (PC), but studies often conflate long-term metabolic exposure, tumor-related prediagnostic metabolic change, and prognosis after diagnosis. This review critically evaluates …
ro
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Accès ouvert
2026
article
OpenAlex
Codruța Claudia Gherman Lencu, Cezara-Andreea Gerdanovics, Olga Hilda Orasan, Ioana Iancu et autres
Bisphenols and phthalates are ubiquitous endocrine-disrupting chemicals with potential effects on reproductive neuroendocrine regulation, particularly during sensitive developmental windows. This review summarizes current evidence on their exposure profile, mechanisms of reproductive disruption, and female- and male-specific reproductive adversities. A structured narrative review …
ro
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Accès ouvert
2026
article
OpenAlex
Crina Veronica Zinveliu (Bercian), Dan Claudiu Măgureanu, Raluca Maria Pop, Adela Sitar-Tăut et autres
Oxidative stress and systemic inflammation are considered key mechanisms linking obstructive sleep apnea (OSA) to cardiovascular disease. This study aimed to investigate the relationships among oxidative stress, nitrosative stress, inflammatory biomarkers, and echocardiographic alterations in OSA. This cross-sectional observational study included 72 …
ro
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Accès ouvert
2026
article
OpenAlex
Mircea Vasile Milaciu, Cezara-Andreea Gerdanovics, Olga Hilda Orasan, Angela Cozma et autres
Introduction: Angiosarcomas are rare malignant vascular tumors. Primary angiosarcoma of the ileum is extremely uncommon, with few cases reported in the literature. Case Report: We report the case of a 54-year-old woman who presented with abdominal pain and constipation. Endoscopic evaluation did …
ro
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Accès ouvert
2026
article
OpenAlex
Anamaria-Vlăduța Tomoiagă, Angela Cozma, Cezara-Andreea Gerdanovics, Alexandru Gerdanovics et autres
Iron is essential for normal cellular function, but its dysregulation is increasingly recognized as a key factor in colorectal tumorigenesis. This review provides an integrated overview of iron-related biomarkers across the full spectrum of colorectal neoplasia, from preneoplastic lesions to advanced colorectal …
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Accès ouvert
2026
review
OpenAlex
Crina Veronica Zinveliu (Bercian), Adela Sitar-Tăut, Angela Cozma, Elena Buzdugan et autres
Obstructive sleep apnea (OSA) constitutes a chronic disorder characterized by recurrent upper airway collapse during sleep. This condition is prevalent among patients with cardiac rhythm disturbances and represents a potent independent risk factor for arrhythmia. Although most studies have concentrated on the …
ro
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Accès ouvert
2026
article
OpenAlex
Anamaria-Vlăduța Tomoiagă, S. Suciu, Cezara-Andreea Gerdanovics, Alexandru Gerdanovics et autres
Colorectal cancer (CRC) is a major global health burden characterized by progressive genetic and metabolic alterations, with iron metabolism being increasingly recognized as a key contributor to tumorigenesis. This review provides an integrated synthesis of current evidence on iron metabolism across the …
ro
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Accès ouvert
2025
article
OpenAlex
Teodora Alexescu, D Lungu, T Popescu, Mirela-Georgiana Perné et autres
Background and Clinical Significance: Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy with increasing incidence among elderly, immunocompromised patients or individuals exposed to ultraviolet radiation. Case Presentation: We present the case of an 84-year-old Caucasian male with no history …
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Accès ouvert
2025
article
OpenAlex
Cezara-Andreea Gerdanovics, S. Suciu, Olga Hilda Orasan, Ioana Para et autres
Cardio-kidney-metabolic (CKM) syndrome represents an integrated clinical and molecular continuum encompassing metabolic dysfunction, cardiovascular disease and chronic kidney disease. This multidimensional disorder arises from interdependent biological pathways that extend beyond conventional risk factors. Emerging evidence highlights a group of adipokines and vascular …
ro
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Accès ouvert
2025
article
OpenAlex
Roxana Liana Lucaciu, Olga Hilda Orasan, Adriana Corina Hangan, Mihaela Iancu et autres
Nowadays, nonalcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver disorder worldwide. From the clinical point of view, it evolves from steatosis to nonalcoholic steatohepatitis, which can lead to cirrhosis and finally to hepatocellular carcinoma. The mechanisms involved …
ro
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Accès ouvert
2025
article
OpenAlex
Enikő Tóthné Kovács, Katalin Szabo, Rodica-Anita Varvara, Alina Uifălean et autres
Resistant starch (RS) is emerging as a multifunctional dietary component and delivery platform for microbiota-accessible carbohydrates. Upon fermentation by gut microbiota, particularly in the colon, RS generates a wide spectrum of postbiotic compounds-including short-chain fatty acids (SCFAs), indoles, bile acid derivatives, and …
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