miRNAs, lncRNAs, circRNAs and piRNAs in Nonalcoholic Fatty Liver Disease: Past, Present and Future
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Le résumé fourni par la source
Nowadays, nonalcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver disorder worldwide. From the clinical point of view, it evolves from steatosis to nonalcoholic steatohepatitis, which can lead to cirrhosis and finally to hepatocellular carcinoma. The mechanisms involved in its progression to more pathological stages and NAFLD pathogenesis are not completely understood. The research concerning NAFLD has become urgent and important because the age of NAFLD diagnosis is progressively decreasing, and its relationship with cancer risk is already well known. Because NAFLD ultimately leads to disability and imposes a major socioeconomic burden, timely diagnosis and effective treatment of NAFLD is particularly important. In the development of NAFLD, noncoding RNAs (ncRNAs) represented by microRNAs, long noncoding RNAs, circular RNAs, and piRNAs are epigenetic factors that play important regulatory roles. In the current review, we present updated information regarding the role of miRNAs, lncRNAs, circRNAs, and piRNAs, aiming to develop a good understanding of their regulatory functions in hepatic metabolism and concerning their potential use as biomarkers for early NAFLD/NASH diagnosis and as therapeutic targets.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- miRNAs, lncRNAs, circRNAs and piRNAs in Nonalcoholic Fatty Liver Disease: Past, Present and Future
- Date Crossref
- 26/10/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Iuliu Hațieganu University of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca Department of Paraclinics pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Pharmaceutical Biochemistry and Clinical Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Department of Molecular Sciences pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Nursing and Health Science Medical Informatics and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Veterinary Medicine Department of Sugery and ATI pays non établi dans la noticeUniversité ou école supérieure
Iuliu Hațieganu University of Medicine and Pharmacy, Department of Paraclinics — University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca et Department of Pharmaceutical Biochemistry and Clinical Laboratory — Faculty of Pharmacy, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.