Heinz Kutzner

Discordance, accuracy and reproducibility study of pathologists’ diagnosis of melanoma and melanocytic tumors

Sarah Haggenmüller, Christoph Wies, Jana Theres Winterstein, Lukas Heinlein et autres

Accurate melanoma diagnosis is crucial for patient outcomes and reliability of AI diagnostic tools. We assess interrater variability among eight expert pathologists reviewing histopathological images and clinical metadata of 792 melanoma-suspicious lesions prospectively collected at eight German hospitals. Moreover, we provide access …

de, us, es, it, fr, gb (code pays fourni par la source)

A 3-dimensional histology computer model of malignant melanoma and its implications for digital pathology

Alexander Kurz, Dieter Krahl, Heinz Kutzner, Raymond L. Barnhill et autres

BACKGROUND: Historically, cancer diagnoses have been made by pathologists using two-dimensional histological slides. However, with the advent of digital pathology and artificial intelligence, slides are being digitised, providing new opportunities to integrate their information. Since nature is 3-dimensional (3D), it seems intuitive …

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Cuticular Poroma: A Rare Poroma Variant Simulating a Malignant Neoplasm That Often Harbors YAP1::NUTM1 Fusions Similar to Their Conventional Counterparts

Isabel Kolm, Anastasia M. Konstantinova, Heinz Kutzner, André Barghorn et autres

ABSTRACT: Cuticular poroma is a rare variant of poroma composed of exclusively or predominantly cuticular cells, namely of large cells with ample eosinophilic cytoplasm. We report 7 cases of this rare tumor identified among 426 neoplasms diagnosed as poroma or porocarcinoma. The …

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A 3-Dimensional Histology Computer Model of Malignant Melanoma and its Implications for Digital Pathology

Alexander Kurz, Dieter Krahl, Heinz Kutzner, Raymond L. Barnhill et autres

de, fr, es, it, us (code pays fourni par la source)

CD64 Staining in Dermatofibroma: A Sensitive Marker Raising the Question of the Cell Differentiation Lineage of This Neoplasm

Mar Llamas‐Velasco, Thomas Mentzel, Enrique Ovejero‐Merino, María Teresa Fernández‐Figueras et autres

Dermatofibroma (DF) is a mesenchymal tumor of the dermis, but its exact differentiation lineage is still uncertain. A progenitor cell that may be able to differentiate into fibroblastic, myofibroblastic, or fibrohistiocytic cells has been hypothesized. Some authors have also proposed the possibility …

es, de (code pays fourni par la source)

Dataset for the Reporting of Merkel Cell Carcinoma

Klaus Johannes BUSAM, Meagan J. Judge, Christopher Keram Bichakjian, Daniel C. Coit et autres

Accurate and complete pathology reports are critical for the optimal management of cancer patients. Protocols for the pathologic reporting of Merkel cell carcinoma (MCC) have been developed independently by the Royal College of Pathologists (UK) and the College of American Pathologists. In …

us, de, es, au, gb, ca (code pays fourni par la source)

Metabolic Signature of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Expression of Hypoxia-inducible Factor-1α and Several of Its Downstream Targets.

Ferdinand Toberer, Julia K. Winkler, Holger Andreas Haenssle, Monika Heinzel‐Gutenbrunner et autres

Metabolic reprogramming mediated by hypoxia-inducible factors play a crucial role in many human cancers. HIF-1α is activated under hypoxic conditions and is considered a key regulator of oxygen homoeostasis during tumor proliferation under hypoxia. Aim of this research was to analyze the …

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NLRP12 and IL36RN mutations in a Portuguese woman with autoinflammatory syndrome

Sofia Antunes‐Duarte, Ana Marcos‐Pinto, Lars Einar French, Heinz Kutzner et autres

Autoinflammatory diseases (AIDs) encompass a genetically heterogeneous group of diseases driven by abnormal activation of the innate immune system.1,2 Patients share recurrent flares of fever, elevation of acute phase reactants, and variable clinical manifestations, including a wide range of cutaneous lesions.2,3

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Genetic and methylation profiles distinguish benign, malignant and spitzoid melanocytic tumors

Anne Zaremba, Philipp Jansen, Rajmohan Murali, Anand Mayakonda et autres

Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow-up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological criteria, however in select cases a definitive diagnostic assessment remains challenging and …

de, us (code pays fourni par la source)

Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid‐organ transplant recipients: a retrospective, multicentre cohort study

Carla Ferrándiz‐Pulido, Álvaro Gómez‐Tomás, B. Llombart, D. López Mendoza et autres

BACKGROUND: The proportion of Merkel cell carcinomas (MCCs) in solid-organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. OBJECTIVE: To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV-status and identify factors …

es, it, tr, nl, fr, gb, cz, at, be, br, de (code pays fourni par la source)

A rare case of cutaneous metastasis of distal phalanx chondrosarcoma.

Catarina Correia, Sónia Sousa Fernandes, Paulo Filipe, Heinz Kutzner et autres

Chondrosarcoma is the second-most common primary malignant bone tumor but chondrosarcoma of small bones of the hand is extremely rare, representing less than 2% of all cases, with exceedingly rare skin metastases. Cutaneous metastases of chondrosarcoma represent less than 3% of all …

pt (code pays fourni par la source)

Explainable artificial intelligence in skin cancer recognition: A systematic review

Katja Hauser, Alexander Kurz, Sarah Haggenmüller, Roman Christoph Maron et autres

BACKGROUND: Due to their ability to solve complex problems, deep neural networks (DNNs) are becoming increasingly popular in medical applications. However, decision-making by such algorithms is essentially a black-box process that renders it difficult for physicians to judge whether the decisions are …

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