Diana Santos Nascimento

Pharmacological clearance of senescent cells reduces inflammation, endothelial damage and cardiac fibrosis in HFpEF

Elsa D. Silva, Inês Tomé, Francisco Vasques-Nóvoa, Glória Conceição et autres

AIMS: Heart failure with preserved ejection fraction (HFpEF) is one of the most common forms of heart failure with no effective treatment. While chronic systemic inflammation, triggered by comorbidities, is a critical factor of HFpEF pathophysiology and a relevant target for therapy, …

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EDP inovação - speeding up underground grids

Eugenio de Grado, Diana Santos Nascimento, Vitor Cabral, Rúben Fernandes et autres

The SUUG (Speed Up Underground Grids) project, tackles the challenges of underground grid construction amidst the energy transition. This paper underscores the necessity of modernizing power grid infrastructure to achieve the ambitious 2050 goals. Collaborating with EDP DSOs in Portugal, Spain, and …

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EDP Inovação - speeding up overhead grids construction

Eugenio de Grado, Diana Santos Nascimento, L. L. Diniz, Christopher Delgado et autres

The SUAG (Speed Up Aerial Grids) project, aims to accelerate aerial grid construction to meet the demands of the energy transition. This paper outlines the current challenges faced by Distribution System Operators (DSOs) and Transmission System Operators (TSOs) in Portugal, Spain, and …

Boosting biocompatibility and minimizing inflammation in electrospun polyvinylidene fluoride (PVDF) cardiac patches through optimized low-pressure plasma treatment

Giorgia Montalbano, Jacopo Barberi, A Benedetto Mas, Trần Thanh Tùng et autres

immune cell infiltration around the patch implanted in infarcted mice, highlighting the surface treatment's effectiveness in enhancing in vivo biocompatibility.

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A high-throughput analysis of novel anti-fibrotics in human adult cardiac fibroblasts

Rita N. Gomes, Maria Cardona-Timoner, Elsa D. Silva, Antonio R. Pombinho et autres

Myocardial fibrosis, a hallmark of heart failure (HF), contributes to disease progression and mortality by impairing cardiac function. Despite the identification of potential anti-fibrotic molecules, there is a lack of effective pharmacological interventions for cardiac fibrosis due to poor translational relevance and …

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Nanoscale piezoelectric patches preserve electrical integrity of infarcted hearts

Luís Miguel Monteiro, Pedro Gouveia, Francisco Vasques‐Nóvoa, Susana Carvalho Rosa et autres

Ischemic heart disease is the leading cause of death worldwide. Several approaches have been explored to restore cardiac function, however few investigated new strategies to improve electrical functional recovery. Herein, we have investigated the impact of piezoelectric patches (Piezo patches), capable of …

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Dressed in Collagen: 2D and 3D Cardiac Fibrosis Models

Maria Cardona-Timoner, Rita N. Gomes, Diana Santos Nascimento

Cardiovascular diseases (CVD), the leading cause of death worldwide, and their strong association with fibrosis highlight the pressing need for innovative antifibrotic therapies. In vitro models have emerged as valuable tools for replicating cardiac fibrosis 'in a dish', facilitating the study of …

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In vitro development of a radicular cyst: A morphological investigation of a spheroid cyst-like model associated with fibroblasts

Diana Santos Nascimento, Luiza Meurer Brand, Lisiane Bernardi, J M Vasconcelos et autres

OBJECTIVE: The aim of this study was to improve the in vitro model of tooth radicular cyst previously developed by incorporating stromal components and to describe histologic analysis. DESIGN: hFIB) to mimic stromal microenvironment. Micrographs were taken to evaluate the cystic stability …

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Piezoelectric electrospun scaffold incorporating ibuprofen loaded ultrasound-responsive mesoporous silica nanoparticles for tissue regeneration

Alice Benedetto Mas, Jacopo Barberi, Giorgia Montalbano, Silvia Fraterrigo Garofalo et autres

. Furthermore, controlled ibuprofen release from the scaffold was successfully triggered on-demand through repeated ultrasound stimulations, applied up to seven days after immersion. By combining structural support, biocompatibility, and the capacity for drug release in response to safe, non-invasive ultrasound stimulations, this …

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DESAFIOS E ESTRATÉGIAS PARA A PROMOÇÃO DA SAÚDE DO ENFERMEIRO: OS PRINCIPAIS FATORES QUE PREJUDICAM A SAÚDE MENTAL DOS PROFISSIONAIS DE ENFERMAGEM NO AMBIENTE DE TRABALHO

Damião Pergentino de Sousa, Diana Santos Nascimento, Karine Vitória Da Silva Ferreira, Lindalva Da Silva Moraes et autres

Este estudo investigou os principais fatores que afetam a saúde mental dos profissionais de enfermagem no ambiente de trabalho, com o objetivo de identificar e discutir estratégias eficazes para a promoção do bem-estar desses profissionais. A enfermagem é uma profissão desafiadora, caracterizada …

A hybrid construct with tailored 3D structure for directing pre-vascularization in engineered tissues

Sara C. Neves, Aureliana Sousa, Diana Santos Nascimento, Iasmim Diniz Orge et autres

Hybrid 3D constructs combining different structural components afford unique opportunities to engineer functional tissues. Creating functional microvascular networks within these constructs is crucial for promoting integration with host vessels and ensuring successful engraftment. Here, we present a hybrid 3D system in which …

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Tunable Hybrid Hydrogels of Alginate and Cell‐Derived dECM to Study the Impact of Matrix Alterations on Epithelial‐to‐Mesenchymal Transition

Patrícia Barros da Silva, Xiaoyu Zhao, Sílvia Joana Bidarra, Diana Santos Nascimento et autres

Epithelial-to-mesenchymal transition (EMT) is crucial for tumor progression, being linked to alterations in the extracellular matrix (ECM). Understanding the ECM's role in EMT can uncover new therapeutic targets, yet replicating these interactions in vitro remains challenging. It is shown that hybrid hydrogels …

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