Ana Campillo-Calatayud

Size in small-for-gestational-age neonates correlates with insulin-like growth factor–binding protein proteolysis and insulin-like growth factor-I bioavailability

Vicente Barrios, Álvaro Martín‐Rivada, Gabriel Ángel Martos‐Moreno, Maria Jiménez‐Hernáiz et autres

Context: Alterations in prenatal growth affect postnatal outcomes, but the factors involved in prenatal growth are not clearly defined. Cord blood levels of insulin-like growth factor (IGF)-I are associated with weight and length at birth; however, how pappalysins (pregnancy-associated plasma protein [PAPP]-A …

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Low rather than high interleukin-6 levels are associated with immune-related adverse events in cancer patients treated with immune checkpoint inhibitors

Íñigo Les, David de Haedo, M. Martínez Kareaga, Berta Ibáñez et autres

Background: Among the biomarkers associated with immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) in cancer patients, interleukin-6 (IL-6) has emerged as a key predictive factor. However, it remains unclear whether high or low levels of IL-6 predispose patients to …

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Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances

Antonio J. López-Gambero, Antonio Vargas, María del Mar Fernández‐Arjona, Leticia Rubio et autres

BACKGROUND: The growth hormone (GH)/insulin-like growth factor (IGF-1) axis determines optimal growth and affects metabolism and energy homeostasis. Pregnancy-associated plasma protein-A2 (PAPPA2) regulates bioactive IGF-1 availability and patients with PAPPA2 deficiency have impaired growth and glucose metabolism. This axis is altered in …

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ABS0115 ASSOCIATION OF IL-6 LEVELS WITH THE RISK OF DEVELOPING IMMUNE-RELATED ADVERSE EVENTS IN PATIENTS WITH CANCER TREATED WITH IMMUNE CHECKPOINT INHIBITORS

I. Les Bujanda, Darío Sánchez, V. Arrazubi Arrula, M. Martínez Kareaga et autres

Background: Immune-related adverse events (irAEs) represent a distinct category of drug toxicity that affects up to 50% of cancer patients treated with immune checkpoint inhibitor (ICI) therapy within the first year of treatment [1]. Among the many biomarkers associated with irAEs, interleukin-6 …

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Prepubertal Children With Obesity Have High Free IGF-1 Levels and Accelerated Growth Despite Reduced Pappalysin Levels

Álvaro Martín‐Rivada, Gabriel Ángel Martos‐Moreno, Santiago Guerra-Cantera, Ana Campillo-Calatayud et autres

BACKGROUND: Prepubertal children with obesity frequently have enhanced growth, accelerated skeletal maturation, and changes in the growth hormone-insulin-like growth factor (GH-IGF) axis. However, the involvement of pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC1, STC2) as regulators of IGF bioavailability has not been studied …

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Baseline Circulating Blood Cell Counts and Ratios and Changes Therein for Predicting Immune-Related Adverse Events during Immune Checkpoint Inhibitor Therapy: A Multicenter, Prospective, Observational, Pan-Cancer Cohort Study with a Gender Perspective

Lucía Teijeira, M. Martínez Kareaga, Amaia Moreno, Ibone de Elejoste et autres

Several factors have been associated with the occurrence of immune-related adverse events (irAEs) induced by immune checkpoint inhibitor (ICI) therapy. Despite their availability, the predictive value of circulating blood cell parameters remains underexplored. Our aim was to investigate whether baseline values of …

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Reduction in Pappalysin-2 Levels and Lower IGF-I Bioavailability in Female Adolescents With Anorexia Nervosa

Vicente Barrios, Álvaro Martín‐Rivada, Santiago Guerra-Cantera, Ana Campillo-Calatayud et autres

CONTEXT: Anorexia nervosa (AN) can cause severe undernutrition associated with alterations in the IGF axis. Pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2) modulate IGF binding-protein (IGFBP) cleavage and IGF bioavailability, but their implications in AN are unknown. OBJECTIVE: We determined serum levels …

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Pappalysins and stanniocalcins and their relationship with the peripheral IGF axis in newborns and during development

Álvaro Martín‐Rivada, S Guerra-Cantera, Ana Campillo-Calatayud, Andres-Esteban EM et autres

Brief summary: Growth Hormone (GH)-Insulin-Growth-Factor-1 (IGF-1) axis plays the major role in promoting growth, but novel factors seem to modulate GH-IGF1 axis functioning. The majority of circulating IGF-1 and IGF-2 are bound to IGF-binding proteins (IGF-BPs) which prolong their half-life and regulate …

Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events

Íñigo Les, M. Martínez Kareaga, Inés Pérez-Francisco, Manuela Moro Cabero et autres

Immune-checkpoint inhibitors (ICIs) are antagonists of inhibitory receptors in the immune system, such as the cytotoxic T-lymphocyte-associated antigen-4, the programmed cell death protein-1 and its ligand PD-L1, and they are increasingly used in cancer treatment. By blocking certain suppressive pathways, ICIs promote …

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Pappalysins and Stanniocalcins and Their Relationship With the Peripheral IGF Axis in Newborns and During Development

Álvaro Martín‐Rivada, Santiago Guerra-Cantera, Ana Campillo-Calatayud, Eva Andrés et autres

CONTEXT: Pappalysins (PAPP-A, PAPP-A2) modulate body growth by increasing insulin-like growth factor I (IGF-I) bioavailability through cleavage of insulin-like growth factor binding proteins (IGFBPs) and are inhibited by stanniocalcins (STC1, STC2). Normative data on these novel factors, as well as on free …

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Chronic Central Leptin Infusion Promotes an Anti-Inflammatory Cytokine Profile Related to the Activation of Insulin Signaling in the Gastrocnemius of Male Rats

Vicente Barrios, Santiago Guerra-Cantera, Álvaro Martín‐Rivada, Sandra Canelles et autres

Leptin is involved in the modulation of insulin signaling in peripheral tissues, being closely associated with changes in lipid metabolism. This adipokine modifies inflammatory pathways that can interact with insulin targets in peripheral organs; however, the mechanisms remain unclear. Inflammatory and insulin …

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Opposite Effects of Chronic Central Leptin Infusion on Activation of Insulin Signaling Pathways in Adipose Tissue and Liver Are Related to Changes in the Inflammatory Environment

Vicente Barrios, Ana Campillo-Calatayud, Santiago Guerra-Cantera, Sandra Canelles et autres

Leptin modulates insulin signaling and this involves the Akt pathway, which is influenced by changes in the inflammatory environment and with leptin regulating cytokine synthesis. We evaluated the association between activation of the insulin-signaling pathway and alterations in pro- and anti-inflammatory cytokine …

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