2024
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OpenAlex
Santiago Guerra-Cantera, Laura M. Frago, Yesenia Espinoza-Chavarria, Roberto Collado‐Perez et autres
INTRODUCTION: Insulin-like growth factor (IGF)1 and IGF2 have neuroprotective effects, but less is known regarding how other members of the IGF system, including IGF binding proteins (IGFBPs) and the regulatory proteinase pappalysin-1 (PAPP-A) and its endogenous inhibitor stanniocalcin-2 (STC2) participate in this …
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2024
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OpenAlex
Álvaro Martín‐Rivada, Gabriel Ángel Martos‐Moreno, Santiago Guerra-Cantera, Ana Campillo-Calatayud et autres
BACKGROUND: Prepubertal children with obesity frequently have enhanced growth, accelerated skeletal maturation, and changes in the growth hormone-insulin-like growth factor (GH-IGF) axis. However, the involvement of pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC1, STC2) as regulators of IGF bioavailability has not been studied …
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2023
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OpenAlex
Vicente Barrios, Álvaro Martín‐Rivada, Santiago Guerra-Cantera, Ana Campillo-Calatayud et autres
CONTEXT: Anorexia nervosa (AN) can cause severe undernutrition associated with alterations in the IGF axis. Pappalysins (PAPP-A, PAPP-A2) and stanniocalcins (STC-1, STC-2) modulate IGF binding-protein (IGFBP) cleavage and IGF bioavailability, but their implications in AN are unknown. OBJECTIVE: We determined serum levels …
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2023
article
OpenAlex
Santiago Guerra-Cantera, Laura M. Frago, Maria Jiménez‐Hernáiz, Roberto Collado‐Perez et autres
Dietary restriction is a frequent strategy for weight loss, but adherence is difficult and returning to poor dietary habits can result in more weight gain than that previously lost. How weight loss due to unrestricted intake of a healthy diet affects the …
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2022
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OpenAlex
Roberto Collado‐Perez, Maria Jiménez‐Hernáiz, Jorge García‐Piqueras, Santiago Guerra-Cantera et autres
Abstract Astrocytes influence neighboring neurons through the release of a variety of signals, including exosomes, micro-vesicles that contain a vast heterogeneity of molecules such as cytokines, growth factors, RNAs and micro-RNAs (mi-RNAs) that modify target cells. We hypothesized that hypothalamic astrocytes communicate …
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2022
article
OpenAlex
Álvaro Martín‐Rivada, Santiago Guerra-Cantera, Ana Campillo-Calatayud, Eva Andrés et autres
CONTEXT: Pappalysins (PAPP-A, PAPP-A2) modulate body growth by increasing insulin-like growth factor I (IGF-I) bioavailability through cleavage of insulin-like growth factor binding proteins (IGFBPs) and are inhibited by stanniocalcins (STC1, STC2). Normative data on these novel factors, as well as on free …
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2022
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OpenAlex
Ana M. Fernández, Laura Martinez‐Rachadell, Marta Navarrete, Julia Pose‐Utrilla et autres
Mice with insulin receptor (IR)–deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas IR-deficient astrocytes show disturbed mitochondrial responses to glucose. While exploring the functional impact of disturbed mitochondrial function in astrocytes, we observed …
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2022
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OpenAlex
Vicente Barrios, Santiago Guerra-Cantera, Álvaro Martín‐Rivada, Sandra Canelles et autres
Leptin is involved in the modulation of insulin signaling in peripheral tissues, being closely associated with changes in lipid metabolism. This adipokine modifies inflammatory pathways that can interact with insulin targets in peripheral organs; however, the mechanisms remain unclear. Inflammatory and insulin …
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2021
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OpenAlex
Vicente Barrios, Julie A. Chowen, Álvaro Martín‐Rivada, Santiago Guerra-Cantera et autres
The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-specific manner that requires precise control that is …
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2021
article
OpenAlex
Santiago Guerra-Cantera, Laura M. Frago, Roberto Collado‐Perez, Sandra Canelles et autres
Dietary intervention is a common tactic employed to curtail the current obesity epidemic. Changes in nutritional status alter metabolic hormones such as insulin or leptin, as well as the insulin-like growth factor (IGF) system, but little is known about restoration of these …
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2021
article
OpenAlex
Vicente Barrios, Ana Campillo-Calatayud, Santiago Guerra-Cantera, Sandra Canelles et autres
Leptin modulates insulin signaling and this involves the Akt pathway, which is influenced by changes in the inflammatory environment and with leptin regulating cytokine synthesis. We evaluated the association between activation of the insulin-signaling pathway and alterations in pro- and anti-inflammatory cytokine …
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2021
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OpenAlex
María Vinaixa, Sandra Canelles, África González‐Murillo, Vítor Ferreira et autres
Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2−/−) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. The differential inflammatory profile and insulin …
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