Anastasiia P. Sazonova

The microbiology of amniotic fluid sludge: a systematic review and meta-analysis

Elena Vasilyevna Shipitsyna, Olga V. Pachuliia, Vladislava V. Khalenko, Ekaterina V. Kopteeva et autres

Abstract Purpose Amniotic fluid sludge (AFS) is a sonographic finding associated with intra-amniotic infection and spontaneous preterm birth. The microbial composition of AFS remains poorly characterized. This systematic review and meta-analysis aimed to consolidate existing data on microbial prevalence in AFS and …

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Differentiated evaluation of intravenous immunoglobulins in patients with recurrent implantation failure in assisted reproductive technology

Ekaterina A. Kornyushina, Vladislava V. Khalenko, Elena Vasilyevna Shipitsyna, Margarita O. Shengelia et autres

BACKGROUND: Currently, the use of intravenous immunoglobulins in patients with recurrent implantation failure after in vitro fertilization is controversial due to the lack of standard treatment protocols and the heterogeneity of patient selection criteria for this therapy. This study was the first …

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Folic acid accumulation in blood plasma and erythrocytes in women of reproductive age depending on vitamin B₉ forms and polymorphic variants of folate pathway genes

Anastasiia P. Sazonova, Yu. P. Milyutina, Elena S. Vashukova, Olga V. Pachuliia et autres

BACKGROUND: Taking the synthetic form of folic acid (vitamin B9 or pteroylmonoglutamic acid) at a dose of 400 mcg at the pregravid stage to correct plasma homocysteine levels can reduce the risk of neural tube defects in fetuses. Furthermore, the use of …

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Clinical data banking in obstetrics—advantages and disadvantages of the strategy using the example of preterm birth risk modeling in multiple pregnancies

Olga V. Pachuliia, Elena Vasilyevna Shipitsyna, Anastasiia P. Sazonova, Yulia A. Nasykhova et autres

BACKGROUND: Despite technological advancements, the key resource for predicting obstetric complications remains the collection and analysis of clinical data. Risk stratification is crucial in obstetrics, enabling tailored antenatal care and preventive measures to reduce preterm birth rates. This is particularly important in …

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The relationship between mineral and vitamin statuses in the blood serum of pregnant women with fetal congenital malformations

Yu. P. Milyutina, Margarita O. Shengelia, Anastasiia P. Sazonova, Olesya Nikolaevna Bespalova et autres

Background: Changes occurring in the body during pregnancy have a significant impact on metabolism, which determines the importance of monitoring nutrition and taking vitamin and mineral supplements for the health of the mother and the normal development of the fetus. An imbalance …

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Effect of synthetic and reduced folic acid on methionine metabolism parameters in various experimental models with Wistar rats

Anastasiia P. Sazonova, Yu. P. Milyutina, Olesya Nikolaevna Bespalova, Olga V. Pachuliia et autres

Introduction. Currently, folic acid preparations are administered during preconception period in an empirical manner. Along with synthetic folic acid, there also exists its reduced counterpart 5-methyltetrahydrofolate (5-MTHF). Manufacturers of the latter claim that 5-MTHF overcomes metabolic defects due to c.665C>T gene polymorphism …

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Micronutrient status of pregnant women with fetal congenital malformations

Yu. P. Milyutina, Margarita O. Shengelia, Olesya Nikolaevna Bespalova, Olga V. Pachuliia et autres

BACKGROUND:Congenital malformations of the central nervous system have extremely severe consequences, which makes it important to study their development and diagnosis during embryogenesis. Therefore, particularly relevant are studies in the field of prevention of fetal сongenital malformations. AIM:The aim of this study …

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Epigenetic mechanisms of intrauterine fetal senescence: little-known effects of hyperhomocysteinemia during pregnancy

Olesya Nikolaevna Bespalova, Olga V. Pachuliia, Anastasiia P. Sazonova, Yu. P. Milyutina et autres

Today, a whole body of evidence base has been formed showing the negative effect of hyperhomocysteinemia (HHC) during pregnancy on the intrauterine fetal development: risk factors associated with development of congenital neural tube defects, congenital heart defects and non-syndromic oral facial clefts. …

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Changes in HbA1c and circulating and adipose tissue androgen levels in overweight‐obese women with polycystic ovary syndrome in response to electroacupuncture

Elisabet Stener‐Victorin, Manuel Alejandro Maliqueo, Marzia Soligo, Virginia Protto et autres

Summary Aim Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS. Material and Methods Seventeen …

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Acupuncture increases whole body glucose uptake during and after stimulation in women with polycystic ovary syndrome

Elisabet Stener‐Victorin, Anna Benrick, Milana Kokosar, Manuel Alejandro Maliqueo et autres

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Dramatically impaired outcome for one IVF twin pregnancy compared to two IVF singleton pregnancies

Anastasiia P. Sazonova, Karin Källén, Ann Thurin‐Kjellberg, U. B. Wennerholm et autres

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Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos

Anastasiia P. Sazonova, Karin Källén, Ann Thurin‐Kjellberg, U. B. Wennerholm et autres

BACKGROUND: There is increasing use of cryopreservation in IVF. This study compared singletons born after cryopreservation with singletons born after fresh IVF cycles and singletons born to women in the general population. METHODS: Data were collected for Swedish IVF treatments during the …

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