Vladislava V. Khalenko

Integrative model of cervical remodeling: associations between ultrasound, immune and microbiological markers

Vladislava V. Khalenko, Olga V. Pachuliia, Ekaterina V. Kopteeva, Olga V. Budilovskaya et autres

Aim : to characterize cervical maturity phenotypes identified by cluster analysis of ultrasound cervicometry and elastography parameters through evaluation of local immunological and microbiological markers associated with cervical remodeling. Materials and Methods . A single-center prospective cohort study with 82 pregnant women …

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The microbiology of amniotic fluid sludge: a systematic review and meta-analysis

Elena Vasilyevna Shipitsyna, Olga V. Pachuliia, Vladislava V. Khalenko, Ekaterina V. Kopteeva et autres

Abstract Purpose Amniotic fluid sludge (AFS) is a sonographic finding associated with intra-amniotic infection and spontaneous preterm birth. The microbial composition of AFS remains poorly characterized. This systematic review and meta-analysis aimed to consolidate existing data on microbial prevalence in AFS and …

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Endometrial microbiota composition, α-defensin and transforming growth factor β1 levels in women with viral infection-driven infertility

Olga V. Budilovskaya, Anastasiya A. Kopylova, Anna А. Krysanova, Tatiana А. Khusnutdinova et autres

A viral infection can interfere with implantation processes, affecting angiogenesis and endometrial receptivity, invasive trophoblast activity, and disrupting the balance of immune factors. The aim of the study was to assess endometrial microbiota composition, to measure the levels of α-defensin, growth factors …

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Early modeling of preterm birth risk using a biocollection of pregnancy samples created at different gestational stages according to the "longitudinal biobanking" strategy

Olga V. Pachuliia, Tatyana E. Lazareva, Vladislava V. Khalenko, R. A. Illarionov et autres

Aim: to develop an algorithm for early modeling of preterm birth (PB) high risk using a biocollection of pregnancy samples created according to the "longitudinal biobanking" strategy, based on clinical, proteomic, and transcriptomic data. Materials and Methods . A prospective cohort study …

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Cervical Maturity Assessment Based on Ultrasound Elastography E‐Cervix

Ekaterina V. Kopteeva, Vladislava V. Khalenko, Olga V. Pachuliia, Olesya Nikolaevna Bespalova

OBJECTIVE: To identify distinct cervical remodeling phenotypes based on ultrasound and quantitative elastography parameters using cluster analysis. METHODS: This single-center, prospective, observational study was conducted from February 2023 to January 2024 and included 373 pregnant women with singleton pregnancies between 6 + …

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Effect of Granulocyte Colony-Stimulating Factor Liposomal Form on the Expression of Genes Associated with Chronic Endometritis

Julian R. Ryzhov, Kseniia V. Obedkova, Vladislava V. Khalenko, Alexander Mkrtichevich Gzgzyan et autres

Abstract While the classical function of granulocyte colony-stimulating factor (G-CSF) is the regulation of neutrophil growth and differentiation, this cytokine also plays an important role in folliculo- and embryogenesis, embryo implantation and trophoblast invasion, thus arousing significant interest in its application in …

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Formulation and In Vitro Characterization of Granulocyte-Colony-Stimulating-Factor-Loaded Liposomes: Future Prospective in Reproductive Medicine

Kseniia V. Obedkova, Vladislava V. Khalenko, Dmitry V. Tovpeko, Julian R. Ryzhov et autres

Drug delivery systems enhance drug efficacy while minimizing side effects. Liposomes, as well-studied and clinically approved carriers, offer biodegradability, biocompatibility, and low toxicity, making them suitable for delivering various pharmacological agents. Granulocyte colony-stimulating factor (G-CSF), a key growth factor, has shown therapeutic …

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CELASTO (Cervical ELASTOgraphy) pilot study — the use of cervical elastography during pregnancy

Vladislava V. Khalenko, Ekaterina V. Kopteeva, Olesya Nikolaevna Bespalova, Olga V. Pachuliia et autres

BACKGROUND: Ultrasound assessment of cervical length is an integral part of a comprehensive examination during pregnancy, but it does not provide a complete picture of structural changes in the cervix. The use of E-Cervix elastography is a promising method to assess cervical …

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Are women with PCOS more at risk for endometrial cancer? What approach for such patients?

Vladislava V. Khalenko, Rosa Anna Guiglia, Marta Alioto

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Biomechanisms of cervical remodeling and current approaches to maturity assessment

Olga V. Pachuliia, Vladislava V. Khalenko, Margarita O. Shengeliia, Olesya Nikolaevna Bespalova

The cervical remodeling process is unique and consists of softening, ripening, dilation at fetal birth, and repair to the original state, which is a dense long tubular structure. In this review, the problem of impaired cervical remodeling is discussed in both preterm …

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Predictors of late complications in pregnant women with arterial hypertension

Vladislava V. Khalenko, Ol’ga Nikolaevna Arzhanova, Elena Vitalievna Mozgovaya

Arterial hypertension occurs in 829% of pregnant women and is a common form of endothelial dysfunction during gestation. In recent decades, the prevalence of arterial hypertension has increased several times largely due to the increasing maternal age of primiparous women and the …

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