Changes in HbA1c and circulating and adipose tissue androgen levels in overweight‐obese women with polycystic ovary syndrome in response to electroacupuncture
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Le résumé fourni par la source
Summary Aim Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS. Material and Methods Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m2 and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole‐body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA1c, circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF). Results No significant change in glucose homeostasis was observed, but HbA1c decreased by 9.5% (p = 0.004), circulating testosterone decreased by 22% (p = 0.0007) and dihydrotestosterone decreased by 12% (p = 0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21% (p = 0.027) and 20% (p = 0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18% (p = 0.049), and androstenedione decreased by 13% (p = 0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p = 0.04). These changes occurred without changes in anthropometrics. Conclusion Five weeks of electroacupuncture treatment improves HbA1c and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Changes in HbA<sub>1c</sub> and circulating and adipose tissue androgen levels in overweight‐obese women with polycystic ovary syndrome in response to electroacupuncture
- Date Crossref
- 09/11/2016
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Karolinska Institutet Department of Physiology and Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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University of Chile Endocrinology and Metabolism Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Istituto di Farmacologia Traslazionale pays non établi dans la noticeStructure de recherche
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University of Gothenburg Institute of Neuroscience and Physiology pays non établi dans la noticeUniversité ou école supérieure
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Sahlgrenska University Hospital pays non établi dans la noticeÉtablissement de santé
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Odense University Hospital Department of Endocrinology pays non établi dans la noticeOrganisme public
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University of Skövde pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Endocrinology and Metabolism Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Institute of Translational Pharmacology – CNR pays non établi dans la noticeStructure de recherche
Department of Physiology and Pharmacology — Karolinska Institutet, Endocrinology and Metabolism Laboratory — University of Chile et Istituto di Farmacologia Traslazionale, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.