Simon J. Leedham

‘A No‐Brainer, but Not a Simple Decision’: A Qualitative Study of Patient Experiences of Tissue Donation for Research in Rare Craniospinal Tumour Pathways

Gerard Mawhinney, S Fourie, Simon J. Leedham, Helen Higham et autres

BACKGROUND: Tissue donation is central to rare tumour research, yet consent is often sought when patients are managing diagnosis, major surgery and uncertainty. Little is known about how people with rare craniospinal tumours experience tissue-donation consent or what support they consider useful. …

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Patient experiences of tissue donation and digital consent support in primary craniospinal tumour research

Gerard Mawhinney, Helen Higham, Simon J. Leedham, Olaf Ansorge

PURPOSE: Requests for tissue donation for research are often made at times of heightened vulnerability, particularly around diagnosis and surgery. This study explored patient experiences of tissue donation discussions, perspectives on consent, and the acceptability of digital decision support in primary craniospinal …

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Stromal Prostaglandin is a Dominant Spatial Regulator of Cell-fate Plasticity in Colorectal Cancer

Christopher J. Tape, Corinne Molyneux, Rhianna O'Sullivan, Eoghan Mulholland-Illingworth et autres

gb, us (code pays fourni par la source)

Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state

Shania M. Corry, Svetlana Sakhnevych, Sudhir B. Malla, Ryan M. Byrne et autres

In colorectal cancer (CRC), tumours classified as consensus molecular subtype 4 (CMS4) have the worst prognosis and derive negligible benefit from chemotherapy. We previously described how repressed interferon-related signalling is associated with increased relapse in CMS4 tumours. Although the viral mimetic polyinosinic:polycytidylic …

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Hallmarks of adaptive immunity in a metastatic clear cell renal cell carcinoma (ccRCC) long-term elite survivor

Felicia Tucci, Edward Drydale, James Bancroft, Sakina Amin et autres

Abstract Clear cell renal cell carcinoma (ccRCC) presents with metastatic disease in nearly one-third of patients, with a 5-year survival of only ∼10%. Although anti-angiogenic therapies and immune checkpoint inhibitors (ICIs) have improved outcomes, therapeutic resistance and immune-related adverse events limit durable …

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Abstract PR004: Multi-omic spatial analysis reveals reshaping of tumour-immune dynamics at the transition to invasive colorectal cancer

Ann‐Marie Baker, Eleanor Smith, Chirine Sakr, Konstantin Bräutigam et autres

Abstract The introduction of bowel cancer screening has led to an increase in the detection and removal of pre-malignant adenomas, however many of these would never progress to colorectal cancer (CRC) within a patient’s lifetime. This implies a key evolutionary bottleneck at …

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Figure S3 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Knockdown of Cdx1, Cdx2 and Hnf4a fails to influence organoid morphology or expression of Btnl genes

Supplementary Figure Legends from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Supplementary Figure Legends

Figure S1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

WNT expression is independent of BTN3A1 and BTN2A1

Figure S2 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Deletion of Apc in organoids increases WNT target genes

Figure S7 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Impact of Btnl1 and Btnl6 expression on Vgamma7+ cells and the tumor microenvironment

Figure S4 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Correlation between gut-specific transcription factors, gamma delta T cell density and BTNL genes in human tumors