Toshiyasu Suzuki

Preclinical efficacy and safety of Tegavivint in Wnt-activated hepatocellular carcinoma

Toshiyasu Suzuki, Ciara Curran, Thomas M Drake, Stephanie May et autres

Abstract Background & Aims Hepatocellular carcinoma (HCC), a predominant form of liver cancer, remains a significant clinical unmet need. Given that 30–50% of HCC cases harbour mutations in the Wnt/β-catenin signalling pathway, targeting this cascade represents a promising therapeutic strategy. However, the …

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COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancer

Toshiyasu Suzuki, Mark J White, J H Leach, Joanne Edwards et autres

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CBL ubiquitin ligase targets translation as a degrader E3

Alice T Wicks, Lori Buetow, Toshiyasu Suzuki, Tobias Schmidt et autres

both lysosomal and proteasomal pathways. Unexpectedly, eIFTerminator4 also caused a decrease in eIF4A and eIF4G levels, leading to a reduction in overall protein translation in cells. Our findings establish proof-of-concept that CBL can function as a degrader E3, expanding the arsenal of …

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Figure S3 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Knockdown of Cdx1, Cdx2 and Hnf4a fails to influence organoid morphology or expression of Btnl genes

Supplementary Figure Legends from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Supplementary Figure Legends

Figure S1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

WNT expression is independent of BTN3A1 and BTN2A1

Figure S2 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Deletion of Apc in organoids increases WNT target genes

Figure S7 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Impact of Btnl1 and Btnl6 expression on Vgamma7+ cells and the tumor microenvironment

Figure S4 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Correlation between gut-specific transcription factors, gamma delta T cell density and BTNL genes in human tumors

Figure S6 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Identification of a WNT responsive element (WRE) in the HNF4G genomic locus.

Figure S5 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Disruption of WNT gradient in normal intestinal villi reduces gamma delta T cells

Table S1 from β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer

Toshiyasu Suzuki, Anna Kilbey, Nuria Casa-Rodríguez, Amy Lawlor et autres

Clinicopathological characteristics of colon cancer patient cohorts.