Teresa Małecka‐Massalska

Plasma HMGB1 as a Potential Biomarker Reflecting the Clinical Outcome in Chronic Heart Failure Patients

Marcin Mazurek, Aneta Skwarek-Dziekanowska, Grzegorz Sobieszek, Teresa Małecka‐Massalska et autres

Background: Chronic heart failure (CHF) is a progressive cardiovascular disease that predominantly affects elderly individuals and significantly impairs quality of life. High mobility group box 1 (HMGB1) has been proposed as a key mediator in the myocardial release of proinflammatory cytokines and …

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Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor

Dominika Pigoń-Zając, Teresa Małecka‐Massalska, Jacek Łapiński, Monika Prendecka

Fungal-derived bioactive compounds are emerging as key components in functional food development, offering new opportunities for health-promoting formulations. The Polyporaceae family, particularly Cerrena unicolor, has demonstrated significant potential due to its rich biochemical profile and diverse health benefits. Despite its extensive bioactive …

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The role of microRNAs in early prediction of lymph node metastasis in breast cancer

Marika Kulczycka, Kamila Derlatka, Justyna Tasior, Monika Prendecka et autres

Background: Breast cancer (BC) remains a leading cause of cancer-related mortality among women worldwide. Metastasis to lymph nodes is a critical determinant of prognosis and treatment decisions. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as promising biomarkers due to their regulatory …

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Identification of Candidate Inflammatory-Nutritional Blood Biomarkers for Cachexia and Muscle Depletion in Polish Chronic Heart Failure Patients

Angelika Szymczak, Aneta Skwarek-Dziekanowska, Grzegorz Sobieszek, Teresa Małecka‐Massalska et autres

Cachexia is a complex syndrome often affecting chronic heart failure (CHF) patients, characterized by muscle wasting and systemic inflammation. Early detection is crucial for improving patient outcomes. This study evaluated candidate inflammatory and nutritional biomarkers, including a novel C-reactive protein-to-albumin ratio (CAR) …

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The cytoprotective role of whey protein hydrolysates against CdCl2-induced toxicity in fibroblasts by the Electric Cell-substrate Impedance Sensing (ECIS) method

Dominika Pigoń-Zając, Hussein B. Khudhur, J.L. Valverde Piedra, Teresa Małecka‐Massalska et autres

INTRODUCTION AND OBJECTIVE: Cadmium (Cd) is a toxic mineral element with a long half-life that causes excessive accumulation in tissues, especially the kidney. It influences cell development, proliferation, and death by activating intracellular signalling pathways. Currently, treatment options include chelation agents and …

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Circulating miRNAs Signature as a Predictor of Cachexia in Chronic Heart Failure: Diagnostic and Prognostic Implications

Tomasz Powrózek, Marcin Mazurek, Aneta Skwarek-Dziekanowska, Grzegorz Sobieszek et autres

Cachexia is defined as a complex wasting syndrome characterized by progressive weight loss, muscle wasting and a systemic inflammatory response. The incidence of cachexia in the course of cardiovascular diseases ranges from 8 to 42% depending on the applied diagnostic criteria. In …

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Is laccase from medicinal mushroom Cerrena unicolor cytotoxic to colon cancer cell line CT-26?

Daria Sondej, Dominika Pigoń-Zając, Magdalena Jaszek, Dawid Stefaniuk et autres

INTRODUCTION AND OBJECTIVE: Colorectal cancer takes an increasing toll every year. Despite the dynamic development of pharmacology, there is still no drug that would be strong enough to cause apoptosis of cancer cells, but at the same time would be free from …

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Anxiety in polycystic ovary syndrome – a meta-analysis

Ewa Humeniuk, Paweł Dybciak, Dorota Raczkiewicz, Tomasz Powrózek et autres

INTRODUCTION AND OBJECTIVE: Polycystic ovary syndrome (PCOS) is one of the most common chronic endocrine disorders. One of the serious comorbidity of PCOS are mental disorders including anxiety disorders. The objective of this meta analysis review was to determine the prevalence, the …

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Comparison of the clinical value of inflammatory blood biomarkers in relation to disease severity and survival in chronic heart failure

Angelika Szymczak, Aneta Skwarek-Dziekanowska, Grzegorz Sobieszek, Teresa Małecka‐Massalska et autres

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Plasma Circulating lncRNAs: MALAT1 and NEAT1 as Biomarkers of Radiation-Induced Adverse Effects in Laryngeal Cancer Patients

Marcin Mazurek, Teresa Małecka‐Massalska, Tomasz Powrózek

Background: The majority of head and neck cancers (HNCs) occur in the larynx. In clinical practice, adverse effects are frequently observed in laryngeal cancer (LC) patients undergoing radiotherapy (RT). Therefore, investigating markers that can predict these unfavorable events is of interest. Long …

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Monitoring Hip Joint Muscle Function in Osteoarthritis Patients Following Arthroplasty: A Prospective Cohort Study

Dorota Staniak, Alicja Wójcik-Załuska, Krzysztof Sokołowski, Małgorzata Drelich et autres

Background/Objectives: Osteoarthritis (OA) is a chronic and progressive joint disease, leading to functional limitations and significantly impairing the quality of life. Muscle weakness, reduced mobility, and compensatory biomechanical changes are common consequences, further exacerbating functional decline. The aim of this study was …

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Blood Circulating LncRNAs: SNHG5 and ZFAS1 as Biomarkers Reflecting Cachexia Incidence in Chronic Heart Failure Patients

Tomasz Powrózek, Marcin Mazurek, Agata Kot‐Wasik, Aneta Skwarek-Dziekanowska et autres

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