Kie Yasuda

Comprehensive analyses of neurodevelopmental outcomes and quality of life of children with biliary atresia

Yoshinori Satomura, Makiko Tachibana, Kie Yasuda, Yuki Yamano et autres

OBJECTIVES: To holistically evaluate neurodevelopmental outcomes and quality of life (QOL) of Japanese patients with biliary atresia (BA) and to investigate the factors associated with the outcomes. METHODS: This study enrolled patients with BA aged 5-18 years who visited Osaka University Hospital …

jp (code pays fourni par la source)

Urinary iodine and thyroglobulin are useful markers in infants suspected of congenital hypothyroidism based on newborn screening

Makiko Tachibana, Yoko Miyoshi, Miho Fukui, Shinsuke Onuma et autres

OBJECTIVES: Iodine deficiency and excess both cause thyroid dysfunction. Few data describe the relationship between iodine status and outcomes of congenital hypothyroidism (CH) in iodine-sufficient areas. We investigated urinary iodine (UI) concentration and its relationship with the clinical course of CH. METHODS: …

jp (code pays fourni par la source)

An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice

Takeshi Kimura, Michaela Kunova Bosakova, Yosuke Nonaka, Eva Hrubá et autres

Achondroplasia is the most prevalent genetic form of dwarfism in humans and is caused by activating mutations in FGFR3 tyrosine kinase. The clinical need for a safe and effective inhibitor of FGFR3 is unmet, leaving achondroplasia currently incurable. Here, we evaluated RBM-007, …

jp, cz, us, es (code pays fourni par la source)

Two girls with a neonatal screening-negative 21-hydroxylase deficiency requiring treatment with hydrocortisone for virilization in late childhood

Shinsuke Onuma, Tomoya Fukuoka, Yoko Miyoshi, Miho Fukui et autres

Herein, we report two girls with a neonatal screening (NS)-negative 21-hydroxylase deficiency (21-OHD) requiring treatment with hydrocortisone due to virilization that developed in late childhood. Patient 1 was born prematurely on the 30th gestational week with normal external genitalia at birth. She …

jp (code pays fourni par la source)

Effects of the FGF2 aptamer on growth plate cartilage development of achondroplasia patient-specific iPS cells in a xenograft model

Takeshi Kimura, Kie Yasuda, Yukako Nakano, Shinji Takeyari et autres

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)

CYP7A1 expression in hepatocytes is retained with upregulated fibroblast growth factor 19 in pediatric biliary atresia

Yasuhiro Hasegawa, Masanobu Kawai, Kazuhiko Bessho, Kie Yasuda et autres

AIM: Bile acid biosynthesis is strictly regulated under physiological conditions. The expression of fibroblast growth factor (FGF) 19 is induced when bile acids bind to the farnesoid X receptor in the intestinal epithelium. Fibroblast growth factor 19 is then transported by the …

jp (code pays fourni par la source)

Evidence for Effects of FGF2 Aptamer in an Achondroplasia Mice Model and an In Vitro Chondrocyte Differentiation System Using Patient-Derived iPS Cells

Keiichi Ozono, Kie Yasuda, Takeshi Kimura, Yukako Nakano et autres

Total Bile Acid Concentration in Duodenal Fluid Is a Useful Preoperative Screening Marker to Rule Out Biliary Atresia

Tomoya Fukuoka, Kazuhiko Bessho, Makiko Tachibana, Yoshinori Satomura et autres

OBJECTIVES: Duodenal tube test (DTT) is used as a preoperative screening to rule out biliary atresia (BA). In previous reports, DTT was assessed by the color of the duodenal fluid, but there were no quantitative criteria. The aim of this study was …

jp (code pays fourni par la source)

Relationship between dose of antithyroid drugs and adverse events in pediatric patients with Graves’ disease

Kie Yasuda, Yoko Miyoshi, Makiko Tachibana, Noriyuki Namba et autres

Graves’ disease (GD) accounts for a large proportion of pediatric hyperthyroidism, and the first-line treatment is antithyroid drug (ATD) therapy. Methimazole (MMI) is effective in most patients but is associated with significant adverse events (AEs). We reviewed the medical records of GD …

jp (code pays fourni par la source)

Longitudinal observation of serum anti-Müllerian hormone in three girls after cancer treatment

Yoko Miyoshi, Kie Yasuda, Makiko Tachibana, Hisao Yoshida et autres

Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. The serum concentration of anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve in survivors. We conducted …

jp (code pays fourni par la source)

Anti-Mullerian Hormone is a Useful Marker of Gonadotoxicity in Girls Treated for Cancer: A Prospective Study

Yoko Miyoshi, Kie Yasuda, Takako Miyamura, Emiko Miyashita et autres

Negative feedback loop of cholesterol regulation is impaired in the livers of patients with Alagille syndrome

Yuki Miyahara, Kazuhiko Bessho, Hiroki Kondou, Yasuhiro Hasegawa et autres

jp (code pays fourni par la source)