Comprehensive analyses of neurodevelopmental outcomes and quality of life of children with biliary atresia
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: To holistically evaluate neurodevelopmental outcomes and quality of life (QOL) of Japanese patients with biliary atresia (BA) and to investigate the factors associated with the outcomes. METHODS: This study enrolled patients with BA aged 5-18 years who visited Osaka University Hospital in 2021. Neurodevelopmental assessments were performed to evaluate intellectual ability, cognitive functions and adaptive skill levels. Furthermore, emotional and behavioral issues, characteristics of attention deficit hyperactivity disorder, and QOL were concomitantly assessed in the same cohort. Biochemical and social factors associated with the results were examined. RESULTS: Fifty-three patients, with a median age of 11.2 years were included in the analyses. Patients with BA had a significantly lower Full-Scale Intelligence Quotient or developmental quotient (FSIQ/DQ) score and Vineland Adaptive Behavior Scale (VABS) composite score than the general Japanese population. Household education level and short stature were associated with low and borderline FSIQ/DQ and VABS composite scores, respectively. Among patients with low and borderline FSIQ/DQ scores, those with average or high VABS composite scores received significantly less neuroeducational care than those with low and borderline VABS composite scores. Despite the low FSIQ/DQ and VABS composite scores, the total QOL scores were higher than those of the general population. CONCLUSION: Patients with BA had intellectual and behavioral impairments. Notably, patients with intellectual impairments are overlooked and not followed up, especially if adaptive skills are maintained.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comprehensive analyses of neurodevelopmental outcomes and quality of life of children with biliary atresia
- Date Crossref
- 06/12/2023
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Osaka Prefectural Medical Center pays non établi dans la noticeÉtablissement de santé
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Health Care Sciences pays non établi dans la noticeUniversité ou école supérieure
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Jikei University of Health Care Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Pediatrics Graduate School of Medicine Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Department of Pediatrics Osaka General Medical Center Osaka Japan Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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United Graduate School of Child Development Osaka University Osaka Japan Molecular Research Center for Children's Mental Development pays non établi dans la noticeUniversité ou école supérieure
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Department of Pediatrics Surgery Graduate School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Medical Safety Management pays non établi dans la noticeUniversité ou école supérieure
Osaka Prefectural Medical Center, The University of Osaka et Graduate School of Health Care Sciences, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.