Relationship between dose of antithyroid drugs and adverse events in pediatric patients with Graves’ disease
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Graves’ disease (GD) accounts for a large proportion of pediatric hyperthyroidism, and the first-line treatment is antithyroid drug (ATD) therapy. Methimazole (MMI) is effective in most patients but is associated with significant adverse events (AEs). We reviewed the medical records of GD patients (n = 56) with onset age of <15 yr and investigated the relationship between MMI dose and AEs. The study population comprised 11 male and 45 female patients and the median age at diagnosis was 11 yr. All patients were initially treated with ATDs. Among the 52 patients initially treated with MMI, 20 received a low dose, and 32 received a high dose of MMI (< 0.7 vs ≥ 0.7 mg/kg/day, respectively). AEs occurred in 20% of the patients in the low-dose MMI group, and in 50% patients in the high-dose MMI group (p = 0.031). A greater variety of AEs was observed in the high-dose group. Neutropenia and rash were observed in both groups. With treatment transition to low-dose MMI according to the Japanese Society for Pediatric Endocrinology guidelines, we expect a decrease in the incidence of AEs in future. However, we should be careful as neutropenia and rash can occur independently of the MMI dose.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Relationship between dose of antithyroid drugs and adverse events in pediatric patients with Graves’ disease
- Date Crossref
- 01/01/2017
- Éditeur
- Japanese Society for Pediatric Endocrinology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Osaka pays non établi dans la noticeUniversité ou école supérieure
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Osaka Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Itami City Hospital pays non établi dans la noticeÉtablissement de santé
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Osaka University Graduate School of Medicine Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Itami Municipal Hospital Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
The University of Osaka, Department of Pediatrics — Osaka Hospital et Itami City Hospital, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.