Koji Yamano

RAB1 mediates OPTN-dependent mitophagy via ATG9A recruitment

Waka Kojima, Ryu Endo, Kei Okatsu, Hiroki Kinefuchi et autres

: AO: antimycin A and oligomycin; ASH: assembly helper; ATG: autophagy related; CALCOCO2: calcium-binding and coiled-coil domain-containing protein 2; CC: coiled coil; ER: endoplasmic reticulum; Fluoppi: fluorescence-based protein-protein interaction; GABARAP: GABA type A receptor-associated protein; GAP: GTPase-activating protein; GEF: guanine nucleotide exchange …

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YhbO is a DJ-1 family glyoxalase and α-oxoaldehyde hydratase that confers resistance to reactive carbonyl stress

Aiko Watanabe, Kai Kanematsu, Yohei Hizukuri, Tatsuki Hori et autres

Reactive α-oxoaldehydes, such as glyoxal (GO) and methylglyoxal (MGO), are cytotoxic glycolysis byproducts that induce cellular dysfunction by nonenzymatically modifying diverse macromolecules. Although DJ-1 (PARK7), a protein linked to Parkinson's disease, acts as a type-III glyoxalase/methylglyoxalase, the physiological function(s) of its prokaryotic …

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BCAS-3 is required for the progression of autophagosome formation to degrade paternal mitochondria in Caenorhabditis elegans

Takuya Norizuki, Taeko Sasaki, Yuji Suehiro, Shohei Mitani et autres

, autophagy degrades paternal mitochondria after fertilization to ensure the maternal inheritance of mitochondrial DNA. We previously showed that the autophagy adaptor ALLO-1 is first targeted to paternal mitochondria and then recruits the autophagy machinery. However, the mechanisms underlying local autophagosome formation …

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RAB7HD/C5orf51 stabilizes newly synthesized RAB7A and facilitates its GTP loading

Koji Yamano, Kei Okatsu, Haruhiro Sano, Reika Kikuchi et autres

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New insights into the essentiality of core autophagy factors revealed by comprehensive analysis

Waka Kojima, Koji Yamano

Autophagy is a conserved degradation process delivering intracellular components to lysosomes or vacuoles. Yeast studies have been pivotal in identifying autophagy-related genes (ATG) and defining the core machinery essential for autophagosome formation. A recent comprehensive analysis that systematically examined all atg mutants …

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Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

Akinori Endo, Chikage Takahashi, Naoko Ishibashi, Yasumasa Nishito et autres

The lysosomal damage response is important for the maintenance of cellular homeostasis in human cells. Although the mechanisms underlying the repair and autophagic elimination of damaged lysosomes have been elucidated, the early signal transduction pathways and genes induced in response to lysosomal …

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Author response: Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

Akinori Endo, Chikage Takahashi, Naoko Ishibashi, Yasumasa Nishito et autres

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Author response: Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

Akinori Endo, Chikage Takahashi, Naoko Ishibashi, Yasumasa Nishito et autres

The lysosomal damage response is important for the maintenance of cellular homeostasis. Although the mechanisms underlying the repair and autophagic elimination of damaged lysosomes have been elucidated, the early signal transduction pathways and genes induced in response to lysosomal damage remain elusive. …

Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

Akinori Endo, Chikage Takahashi, Naoko Ishibashi, Yasumasa Nishito et autres

Abstract The lysosomal damage response is important for the maintenance of cellular homeostasis. Although the mechanisms underlying the repair and autophagic elimination of damaged lysosomes have been elucidated, the early signal transduction pathways and genes induced in response to lysosomal damage remain …

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Functional and Structural Insights Into Complex Formation Between OPTN Leucine Zipper Domain and RAB8A

Kei Okatsu, Reika Kikuchi, Noriyuki Matsuda, Shuya Fukai et autres

Optineurin (OPTN) is a multifunctional adaptor protein involved in vesicular trafficking and selective autophagy. In this study, we investigated the molecular mechanism by which OPTN regulates these distinct processes through the leucine zipper (LZ) domain. OPTN interacts with the active form of …

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The reaction mechanism for glycolysis side product degradation by Parkinson’s disease–linked DJ-1

Aiko Watanabe, Shizuka Ogiwara, Masaki Mishima, Masahiro Yamashina et autres

DJ-1/PARK7 is the causative gene for hereditary recessive Parkinson's disease. Recent studies have reported that DJ-1 hydrolyzes cyclic 3-phosphoglyceric anhydride (cPGA), a highly reactive metabolite. However, the molecular mechanisms underlying cPGA hydrolase activity have yet to be fully elucidated. To gain a …

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Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

Akinori Endo, Chikage Takahashi, Naoko Ishibashi, Yasumasa Nishito et autres

The lysosomal damage response is important for the maintenance of cellular homeostasis in human cells. Although the mechanisms underlying the repair and autophagic elimination of damaged lysosomes have been elucidated, the early signal transduction pathways and genes induced in response to lysosomal …

jp (code pays fourni par la source)