Alexandra Rêma

Isolation, Expansion, Molecular Characterization, and Synergistic Antioxidant Protection of Rat Spermatogonial Stem Cells Using Mangiferin and Sodium Selenite

Leda Maria Costa Pereira Bersano, Patrícia Sousa, Irina Amorim, Alexandra Rêma et autres

Gonadal toxicity from cancer treatments highlights the need for efficient spermatogonial stem cell (SSC) isolation and expansion protocols for fertility preservation. This study aimed to isolate and culture rat SSCs and evaluate the cytoprotective and antioxidant effects of mangiferin (M) and sodium …

Neuronal Differentiation and Exosome Profiling of Dental Pulp Stem Cells: Unveiling Their Potential for Nerve Repair

Bruna dos Santos Lopes, Patrícia Sousa, Alícia de Sousa Moreira, Ana Catarina Sousa et autres

Peripheral nerve injuries remain a major clinical problem, and cell-free therapies using stem cell-derived bioproducts have emerged as promising alternatives. This study evaluated the influence of neurogenic differentiation and passage number on the secretomic and exosomal profile of human dental pulp stem …

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Neuronal Differentiation and Exosome Profiling of Dental Pulp Stem Cells: Unveiling Their Potential for Nerve Repair

Bruna dos Santos Lopes, Patrícia Sousa, Alícia de Sousa Moreira, Ana Catarina Sousa et autres

Peripheral nerve injuries remain a major clinical problem, and cell-free therapies using stem cell-derived bioproducts have emerged as promising alternatives. This study evaluated the influence of neurogenic differentiation and passage number on the secretomic and exosomal profile of human dental pulp stem …

it (code pays fourni par la source)

Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of Their In Vitro Wound Healing Potential

Patrícia Sousa, Bruna dos Santos Lopes, Ana Catarina Sousa, Alícia de Sousa Moreira et autres

Stem cell-derived secretome and exosomes present a promising cell-free strategy for tissue repair and wound healing. This study aimed to isolate and characterize, for the first time, exosomes derived from rat hair follicle stem cells (rHFSCs) and to evaluate their wound-healing potential …

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Combined use of olfactory mucosal mesenchymal stem cells conditioned medium and neural guide conduits promotes nerve regeneration in an ovine model

Rui Alvites, Bruna dos Santos Lopes, André Filipe Coelho, Ana Catarina Sousa et autres

Introduction: Peripheral nerve injuries remain a significant clinical challenge, particularly in severe neurotmesis injuries requiring complex therapeutic interventions to restore functionality. This study aimed to evaluate the pro-regenerative potential of combining neural guide conduits with conditioned medium from olfactory mucosa mesenchymal stem …

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Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of their in Vitro Wound Healing Potential

Patrícia Sousa, Bruna dos Santos Lopes, Ana Catarina Sousa, Alícia de Sousa Moreira et autres

Background: Stem cell-derived secretome and exosomes present a promising cell-free strategy for tissue repair and wound healing. This study aimed to isolate and characterize, for the first time, exosomes derived from rat hair follicle stem cells (rHFSCs) and to evaluate their wound-healing …

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Honey, Gellan Gum, and Hyaluronic Acid as Therapeutic Approaches for Skin Regeneration

Patrícia Sousa, Alícia de Sousa Moreira, Bruna dos Santos Lopes, Ana Catarina Sousa et autres

Background/Objectives: Chronic wounds pose a significant health concern, with their prevalence increasing due to various etiologies. The global aging population further contributes to this rise, placing a substantial burden on healthcare systems in developed countries. This work aimed to develop new therapeutic …

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Combined Use of Olfactory Mucosal Mesenchymal Stem Cells Secretome and Neural Guide Conduits Promotes Nerve Regeneration in an Ovine Model

Rui Alvites, Bruna dos Santos Lopes, André Filipe Coelho, Ana Catarina Sousa et autres

Peripheral nerve injuries remain a significant clinical challenge, particularly in severe neurotmesis injuries requiring complex therapeutic interventions to restore functionality. This study evaluated the pro-regenerative potential of combining neural guide conduits with secretome from olfactory mucosa mesenchymal stem cells, compared to gold-standard …

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Withdrawn: Honey, Gellan Gum and Hyaluronic Acid as Therapeutic Approaches for Skin Regeneration

Patrícia Sousa, Alícia de Sousa Moreira, Bruna dos Santos Lopes, Ana Catarina Sousa et autres

Chronic wounds pose a significant health concern and their prevalence, stemming from different etiologies, is on the rise due to the global aging population, posing a substantial burden on healthcare systems in developed countries. This work aimed to develop and formulate new …

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Exploring the potential of Nano carrier for cancer immunotherapy: A comprehensive review

P.S. Pavithra, Ranita Devi S, K. Pritha, S Priyanka et autres

The host immune system possesses an intrinsic ability to target and kill cancer cells in a specific and adaptable manner that can be further enhanced by cancer immunotherapy, which aims to train the immune system to boost the antitumor immune response.This review …

Isolation, Expansion, and Characterization of Rat Hair Follicle Stem Cells and Their Secretome: Insights into Wound Healing Potential

Patrícia Sousa, Bruna dos Santos Lopes, Ana Catarina Sousa, André Filipe Coelho et autres

Background: Stem cells are capable of self-renewal and differentiation into various specialized cells, making them a potential therapeutic option in regenerative medicine. This study establishes a comprehensive methodology for isolating, culturing, and characterizing rat hair follicle stem cells. Methods and Results: Hair …

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Isolation, Expansion and Characterization of Rat Hair Follicle Stem Cells

Patrícia Sousa, Bruna dos Santos Lopes, Ana Catarina Sousa, André Filipe Coelho et autres

Stem cells are capable of self-renewal and differentiation into various specialized cells, making them a potential therapeutic option in regenerative medicine. This study establishes a comprehensive methodology for isolating, culturing, and characterizing rat hair follicle stem cells. Hair follicles were harvested from …