Honey, Gellan Gum, and Hyaluronic Acid as Therapeutic Approaches for Skin Regeneration
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Le résumé fourni par la source
Background/Objectives: Chronic wounds pose a significant health concern, with their prevalence increasing due to various etiologies. The global aging population further contributes to this rise, placing a substantial burden on healthcare systems in developed countries. This work aimed to develop new therapeutic options in the form of creams and dressings based on honey, gellan gum, and hyaluronic acid for preventing and treating chronic wounds across all stages. Methods: To address this, after the formulations were developed, in vitro cytocompatibility was determined. To confirm biocompatibility, an ovine wound model was used: full-thickness excisional wounds were treated with three formulations, namely gellan gum and honey sponges (GG-HNY), gellan gum, honey and hyaluronic acid sponges (GG-HA-HNY) and a honey-based cream (cream FB002). Daily assessments, including visual evaluation and wound scoring, were conducted for 30 days. Following the study period, tissues were collected for histological analyses. Results: The macroscopic examination revealed that all therapeutic groups facilitated lesion closure. Lesion size reduction, granulation tissue disappearance, and scar tissue development were consistent across all groups, with the group receiving cream demonstrating an advanced stage of healing. All groups achieved substantial wound closure by day 30, with no significant differences. Histopathological analysis following ISO standards revealed that GG-HA-HNY had the lowest ISO score, indicating minimal reactivity and inflammation, which corroborated the cytocompatibility. Conclusions: Combining these insights with previous findings enhances our understanding of wound regeneration dynamics and contributes to refining therapeutic strategies for chronic wounds. The formulations were designed to balance therapeutic efficacy with cost-effectiveness, leveraging low-cost raw materials and straightforward production methods.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Honey, Gellan Gum, and Hyaluronic Acid as Therapeutic Approaches for Skin Regeneration
- Date Crossref
- 18/02/2025
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade do Porto Instituto de Ciências pays non établi dans la noticeUniversité ou école supérieure
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Centro de Estudos de Ciencia Animal pays non établi dans la noticeStructure de recherche
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3B's Research Group pays non établi dans la noticeStructure de recherche
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University of Minho I3Bs—Research Institute on Biomaterials pays non établi dans la noticeUniversité ou école supérieure
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Cooperativa de Ensino Superior Politécnico e Universitário pays non établi dans la noticeUniversité ou école supérieure
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Associate Laboratory for Animal and Veterinary Science (AL4AnimalS) pays non établi dans la noticeStructure de recherche
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Centro Clínico de Equinos de Vairão (CCEV) Campus Agrário de Vairão pays non établi dans la noticeÉtablissement de santé
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ICVS/3B’s—PT Government Associated Laboratory pays non établi dans la noticeStructure de recherche
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ICBAS—School of Medicine and Biomedical Sciences Departamento de Patologia e Imunologia Molecular pays non établi dans la noticeUniversité ou école supérieure
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University of Porto (IPATIMUP) Institute of Molecular Pathology and Immunology pays non établi dans la noticeUniversité ou école supérieure
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Finao Biotech Lda pays non établi dans la noticeInstitution
Instituto de Ciências — Universidade do Porto, Centro de Estudos de Ciencia Animal et 3B's Research Group, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.