Alícia Moreira

Integrated Characterization of Cytokine-Primed and Non-Primed Umbilical Cord Mesenchymal Stromal Cell Secretome in an Ocular Tolerance Model Relevant to Glaucoma Research

Alícia Moreira, Bruna Lopes, A Sà Sousa, Patrícia Sousa et autres

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Stem cell–derived secretome: a novel strategy for wound healing

Patrícia Sousa, Ana Sousa, Alícia Moreira, Bruna Lopes et autres

Chronic non-healing wounds, including diabetic ulcers, venous leg ulcers, and pressure ulcers, represent a significant clinical burden worldwide, associated with major economic costs and impaired quality of life. Although stem cell-based therapies have shown regenerative potential, recent accumulating evidence indicates that their …

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Stem cell-derived secretome and dental pulp stem cells enhance sciatic nerve regeneration in a rat sciatic neurotmesis model using chitosan nerve conduits

Bruna Grance Lopes, Ana Sousa, Alícia Moreira, Patrícia Sousa et autres

Introduction: Peripheral nerve injuries remain a major clinical challenge, often leading to long-term motor and sensory deficits. Stem cell-based and cell-free approaches, combined with biomaterial scaffolds, have emerged as promising strategies for nerve repair. Methods: This study evaluated the regenerative potential of …

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Neuronal Differentiation and Exosome Profiling of Dental Pulp Stem Cells: Unveiling Their Potential for Nerve Repair

Bruna Lopes, Patrícia Sousa, Alícia Moreira, Ana Catarina Sousa et autres

Peripheral nerve injuries remain a major clinical problem, and cell-free therapies using stem cell-derived bioproducts have emerged as promising alternatives. This study evaluated the influence of neurogenic differentiation and passage number on the secretomic and exosomal profile of human dental pulp stem …

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Neuronal Differentiation and Exosome Profiling of Dental Pulp Stem Cells: Unveiling Their Potential for Nerve Repair

Bruna Lopes, Patrícia Sousa, Alícia Moreira, Ana Catarina Sousa et autres

Peripheral nerve injuries remain a major clinical problem, and cell-free therapies using stem cell-derived bioproducts have emerged as promising alternatives. This study evaluated the influence of neurogenic differentiation and passage number on the secretomic and exosomal profile of human dental pulp stem …

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Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of Their In Vitro Wound Healing Potential

Patrícia Sousa, Bruna Lopes, Ana Catarina Sousa, Alícia Moreira et autres

Stem cell-derived secretome and exosomes present a promising cell-free strategy for tissue repair and wound healing. This study aimed to isolate and characterize, for the first time, exosomes derived from rat hair follicle stem cells (rHFSCs) and to evaluate their wound-healing potential …

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Combined use of olfactory mucosal mesenchymal stem cells conditioned medium and neural guide conduits promotes nerve regeneration in an ovine model

Rui Alvites, Bruna Lopes, André Coelho, Ana Catarina Sousa et autres

Introduction: Peripheral nerve injuries remain a significant clinical challenge, particularly in severe neurotmesis injuries requiring complex therapeutic interventions to restore functionality. This study aimed to evaluate the pro-regenerative potential of combining neural guide conduits with conditioned medium from olfactory mucosa mesenchymal stem …

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Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of their in Vitro Wound Healing Potential

Patrícia Sousa, Bruna Lopes, Ana Catarina Sousa, Alícia Moreira et autres

Background: Stem cell-derived secretome and exosomes present a promising cell-free strategy for tissue repair and wound healing. This study aimed to isolate and characterize, for the first time, exosomes derived from rat hair follicle stem cells (rHFSCs) and to evaluate their wound-healing …

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In vitro evaluation of dental pulp stem cells for sciatic nerve regeneration: foundations for future in vivo applications

Bruna Lopes, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira et autres

Introduction: Peripheral nerve injuries, resulting from trauma or medical interventions, present significant clinical challenges due to their severe physiological and functional impacts. Despite various therapeutic approaches, optimal methods for promoting nerve regeneration remain difficult to obtain. This study is a preliminary step …

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Honey, Gellan Gum, and Hyaluronic Acid as Therapeutic Approaches for Skin Regeneration

Patrícia Sousa, Alícia Moreira, Bruna Lopes, Ana Catarina Sousa et autres

Background/Objectives: Chronic wounds pose a significant health concern, with their prevalence increasing due to various etiologies. The global aging population further contributes to this rise, placing a substantial burden on healthcare systems in developed countries. This work aimed to develop new therapeutic …

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Combined Use of Olfactory Mucosal Mesenchymal Stem Cells Secretome and Neural Guide Conduits Promotes Nerve Regeneration in an Ovine Model

Rui Alvites, Bruna Lopes, André Coelho, Ana Catarina Sousa et autres

Peripheral nerve injuries remain a significant clinical challenge, particularly in severe neurotmesis injuries requiring complex therapeutic interventions to restore functionality. This study evaluated the pro-regenerative potential of combining neural guide conduits with secretome from olfactory mucosa mesenchymal stem cells, compared to gold-standard …

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Withdrawn: Honey, Gellan Gum and Hyaluronic Acid as Therapeutic Approaches for Skin Regeneration

Patrícia Sousa, Alícia Moreira, Bruna Lopes, Ana Catarina Sousa et autres

Chronic wounds pose a significant health concern and their prevalence, stemming from different etiologies, is on the rise due to the global aging population, posing a substantial burden on healthcare systems in developed countries. This work aimed to develop and formulate new …

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