Alanna A. Morris

Mortality benefit and lifetime survival gains with vericiguat in HFrEF: Bayesian and actuarial analyses of the VICTOR trial

Francesco Fioretti, Faı̈ez Zannad, Derek Cyr, Kevin J Anstrom et autres

BACKGROUND: The VICTOR trial did not meet its primary composite endpoint of cardiovascular death or first hospitalization for heart failure (HF) but demonstrated a nominally significant reduction in the prespecified and powered endpoint of cardiovascular death with vericiguat in patients with HF …

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Barriers to Optimization of Medical Therapy and the Role of Checklist‐Based Decision Support in Heart Failure

Brett Montelaro, Edward Woods, Candace D. Speight, Eisha P. Udeshi et autres

BACKGROUND: Guideline-directed medical therapy (GDMT) reduces morbidity and mortality in heart failure with reduced ejection fraction, yet it remains underused. Patient-activation interventions, including checklist-based decision support, have shown improvement in GDMT optimization, and iterative refinement of such tools may enhance their impact. …

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26-A-10800-ACC ASSESSING FACTORS ASSOCIATED WITH SODIUM-GLUCOSE COTRANSPORTER 2 INHIBITORS INITIATION IN A CONTEMPORANEOUS COHORT OF NEWLY DIAGNOSED HF PATIENTS FROM THE US

Carolyn S.P. Lam, Gregg C. Fonarow, Yik Ming Fung, Maria Sonia Ares Gomez et autres

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Impact of Baseline Renal Function on Waitlist Outcomes in Patients Supported With Impella as a Bridge to Heart Transplantation

Apoorva Gangavelli, Rebecca S. Steinberg, Daniel Mathew, Krishan Patel et autres

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Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial

Javed Butler, Ciaran J. McMullan, Kevin J. Anstrom, Irina Barash et autres

us, ch, ca, sg, pl, it, co, de, nl, fr (code pays fourni par la source)

Identification of Anti-A2 Alloreactive Quasi-Public CD8+ T Cell Meta-Clonotypes via Bulk and Paired TCR Sequencing

Wen Zhang, Fernanda Marconi Roversi, Alanna A. Morris, Alison Hadley et autres

Purpose: TCR sequencing of blood samples has emerged as a promising, non-invasive tool for detecting T cell responses to pathogens. This approach provides valuable insights into prior immune exposure and the magnitude of ongoing immune responses. Here, we employed TCR sequencing to …

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COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine

Alanna A. Morris, Mirnela Byku, Nathan W. Cummins, Sony Tuteja et autres

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Belatacept-based immunosuppression in heart transplant recipients: A single center experience

Wairimu Magua, Maggie Wang, Darlington D. Pobee, Anna B. Morris et autres

Background: We aim to describe the effect of belatacept on de novo donor-specific antibodies (DSA) formation, rejection, and renal function in heart transplant recipients. Methods: The cohort comprises 60 adult heart or heart-kidney recipients transplanted between 2005 and 2022. Twelve recipients initialized …

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Finerenone in Heart Failure With Improved Ejection Fraction

Maria Pabón, Orly Vardeny, Muthiah Vaduganathan, Akshay S. Desai et autres

Importance: Patients with chronic heart failure (HF) and left ventricular ejection fraction (LVEF) less than 40% who experience LVEF improvement to 40% or higher (HFimpEF) may still face residual risks. Objective: To assess the clinical profiles, risk, and treatment response to finerenone …

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Effects of Finerenone on Readmissions for Heart Failure: Insights From the FINEARTS-HF Trial

Ankeet S. Bhatt, Muthiah Vaduganathan, Brian Claggett, Pardeep S. Jhund et autres

Dr. Bhatt has received research grant support to his institution from National Institutes of Health/National Heart, Lung, and Blood Institute, National Institutes of Health/National Institute on Aging, American College of Cardiology Foundation, and the Centers for Disease Control and Prevention and consulting …

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Association of stress-induced autonomic dysfunction with heart failure in individuals with stable coronary artery disease

Maggie Wang, Chang Liu, Anish Shah, Yi-An Ko et autres

Background: Heart failure (HF) is a common complication in individuals with coronary artery disease (CAD). Autonomic effects of psychological stress may play an important, under-recognized role in this relationship. We hypothesized that stress-induced autonomic dysfunction, measured by change in low-frequency heart rate …

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A series of randomized trials of behavioral economic interventions to increase racial and ethnic diversity of research participants: Rationale and design of ITERATE

Nirali Patel, Casey Whitman, Shira Blady, Colleen Morse et autres

RATIONALE: Prospective clinical research studies are essential for determining the effectiveness and safety of drugs, medical devices, and healthcare delivery interventions. However, low enrollment, particularly among Black and Hispanic patients, challenges the generalizability of results and fairness of research. Leveraging insights from …

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