Nirali Patel

Chiari type 1 malformations and hypermobility spectrum disorder: clinical outcomes and the importance of the differential diagnosis

Laurence Davidson, Patrick F. O’Brien, Jean-Paul Bryant, Saige Teti et autres

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Barriers and Benefits of Subsidized Medical Cannabis in Oncologic Outpatient Palliative Care

Ivan Gonzalez Corral, Kathryn McGrath, Pallavi Kumar, Nicholas S. Bishop et autres

A series of randomized trials of behavioral economic interventions to increase racial and ethnic diversity of research participants: Rationale and design of ITERATE

Nirali Patel, Casey Whitman, Shira Blady, Colleen Morse et autres

RATIONALE: Prospective clinical research studies are essential for determining the effectiveness and safety of drugs, medical devices, and healthcare delivery interventions. However, low enrollment, particularly among Black and Hispanic patients, challenges the generalizability of results and fairness of research. Leveraging insights from …

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1151 Sonodynamic Therapy (SDT) Using Intravenous 5-aminolevulinic Acid With MR-Guided Focused Ultrasound (MRgFUS) for the Treatment of Diffuse Intrinsic Pontine Gliomas in Pediatrics: Initial Safety and Outcomes of the Multicenter SDT-201 Trial

Kelsi Chesney, Gregory Keating, Nirali Patel, Lindsay Kilburn et autres

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is the leading cause of mortality amongst pediatric neuro-oncologic diseases. Sonodynamic therapy with MR-guided focused ultrasound (MRgFUS) is being investigated in multiple clinical trials. METHODS: Twelve patients with DIPG were treated from August 2022-April 2024 as …

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

Arpine Sokratian, Ye Zhou, Meltem Tatlı, Kevin Burbidge et autres

The intricate process of α-synuclein aggregation and fibrillization holds pivotal roles in Parkinson's disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can fibrillize in vitro, whether these fibrils commonly used in research to induce this process or form can reproduce …

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CTNI-74. SONODYNAMIC THERAPY (SDT) USING INTRAVENOUS 5-AMINOLEVULINIC ACID WITH NON-ABLATIVE FOCUSED ULTRASOUND FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMAS IN PEDIATRICS: INITIAL SAFETY AND OUTCOMES THE MULTICENTER SDT-201 TRIAL

Lindsay Kilburn, Robert F. Keating, Nirali Patel, Adriana Fonseca et autres

Abstract Diffuse intrinsic pontine glioma (DIPG) is the leading cause of mortality amongst pediatric neuro-oncologic diseases. Sonodynamic therapy with non-ablative MR-guided focused ultrasound (MRgFUS) is being investigated in multiple clinical trials. We describe safety outcomes and initial efficacy of SDT with 5-ALA …

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MR-guided focused ultrasound in pediatric neurosurgery: current insights, technical challenges, and lessons learned from 45 treatments at Children’s National Hospital

Gregory Keating, Kelsi Chesney, Nirali Patel, Lindsay Kilburn et autres

OBJECTIVE: MR-guided focused ultrasound (MRgFUS) is an evolving technology with numerous present and potential applications in pediatric neurosurgery. The aim of this study was to describe the use of MRgFUS, technical challenges, complications, and lessons learned at a single children's hospital. METHODS: …

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Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases

Arpine Sokratian, Ye Zhou, Meltem Tatlı, Kevin Burbidge et autres

Short Abstract The intricate process of α-synuclein aggregation and fibrillization hold pivotal roles in Parkinson’s disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can fibrillize in vitro , whether these fibrils commonly used in research to induce this process or …

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The role of focused ultrasound for pediatric brain tumors: current insights and future implications on treatment strategies

Kelsi Chesney, Gregory Keating, Nirali Patel, Lindsay Kilburn et autres

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181 Initial Experience With Sonodynamic Therapy Using Low-Intensity Focused Ultrasound and ALA for Pediatric Patients With Diffuse Intrinsic Pontine Glioma

Nirali Patel, Kelsi Chesney, Jean-Paul Bryant, Kristen Stabingas et autres

INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain tumor with poor prognosis. Aminolevulinic acid (ALA) sonodynamic therapy (SDT) is a non-invasive strategy where tissues sensitized with ALA are exposed to MR-guided focused ultrasound (MRgFUS). Preclinical studies have demonstrated significant …

Evolution of Surgical Management of Pineal Region Tumors in the Pediatric Population: A 17-Year Experience at a Single Institution

Nirali Patel, Alexandria Marino, Kelsi Chesney, Jean Paul Bryant et autres

INTRODUCTION: Pineal region tumors have historically been challenging to treat. Advances in surgical techniques have led to significant changes in care and outcomes for these patients, and this is well demonstrated by our single institution's experience over a 17-year-period in which the …

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Current Applications of VR/AR (Virtual Reality/Augmented Reality) in Pediatric Neurosurgery

Nirali Patel, Katherine Hofmann, Robert F. Keating

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